Richard Neher

Richard Neher

@neher.io

711 followers275 following37 posts

Richard Neher reposted

The achievement of Serbian students overthrowing Aleksandar Vučić can't be overstated. In 2024, they began protesting. In 2025, they transformed a protest movement into civil dissidence. In 2026, they became a political party — and two months later, crushed a corrupt state-entrenched authoritarian.

Richard Neher reposted

Remember this? bsky.app/profile/did:... Rigorous visualization of the structure in your high-dimensional data. Fantastic work by @dhdegroot.bsky.social With help of the reviewers of Nat Biotech it is now updated, extended an officially published here: www.nature.com/articles/s41... 1/n

nature.comBonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data - Nature BiotechnologyHigh-dimensional data are visualized through representation on tree structures.
Erik van Nimwegen@erikvannimwegen.bsky.social

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...

Richard Neher reposted

This was a groundbreaking piece of work. A work so good it means a life well spent. Millions of people understand Iran, the diaspora and the weird bittersweet details of the immigrant experience through the work she did.

Seán Costello@seanjcostello.bsky.social

Sad to hear Marjane Satrapi, author of this extraordinary memoir, has died

Richard Neher reposted

Richard Neher reposted

The world of influenza science has lost one of its giants. Nancy Cox, who led #CDC's flu division for years & worked assiduously to improve global flu surveillance, died Thursday. I learned a ton from Nancy Cox. RIP. www.statnews.com/2026/04/25/n...

statnews.comNancy Cox, a CDC veteran and a stalwart in global flu research, dies at 77Nancy Cox, a CDC veteran who for decades was a global leader in influenza research, has died at 77.

Richard Neher reposted

Tonight in Budapest’s Heroes’ Square, a sea of young Hungarians—who’ve only ever known Orbán’s corrupt, suffocating regime—are packed together, singing, chanting, and daring to dream of freedom again. Their hope is raw, their courage is real. The heart of Europe is beating in Budapest tonight. 🇭🇺❤️🇪🇺

Richard Neher reposted

American and Israeli missiles hit Sharif University in Tehran tonight. Often called #Iran’s MIT, the institution has been home to some of the country’s best and brightest minds in science, technology, engineering, and mathematics since 1966. 1/2

Richard Neher reposted

“[P]utting data into GISAID is like dropping it in a mail slot in an unmarked building,” says @colincarlson.bsky.social. “It’s wonderful that there’s so much cool stuff in that building. It would be great if we knew who owned it, or who paid for it, or what they plan to do with it.” #IDsky 🧪

science.orgFresh conflicts erupt around giant database for flu and COVID-19 sequencesCritics say “autocratic” behavior by GISAID could hamper response to a future pandemic

Richard Neher reposted

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8

Richard Neher reposted

On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5

Richard Neher reposted

Job alert🚨📢! Join us as Director of the SIB Centre for Pathogen Bioinformatics, on a topic where global collaboration is particularly important, in a highly stimulating environment. This is a research infrastructure leadership position. Apply or spread the word! apply.refline.ch/499599/0346/...

apply.refline.chDirector, Center for Pathogen BioinformaticsThe Centre for Pathogen Bioinformatics (CPB) is a unit of SIB which offers expertise and services in pathogen bioinformatics, computational molecular epidemiology and related multi-site project manage...

Richard Neher reposted

📣 Germany's close to reversing its opposition to mass surveillance & private message scanning, & backing the Chat Control bill. This could end private comms-& Signal-in the EU. Time's short and they're counting on obscurity: please let German politicians know how horrifying their reversal would be.

Signal@signal.org

We are alarmed by reports that Germany is on the verge of a catastrophic about-face, reversing its longstanding and principled opposition to the EU’s Chat Control proposal which, if passed, could spell the end of the right to privacy in Europe. signal.org/blog/pdfs/ge...

Richard Neher reposted

Richard Neher reposted

Richard Neher reposted

Sometimes you meet absolutely incredible bioinfo-magicians. It was a huge privilege when @shenwei356.bsky.social joined our group for a year on an @embl.org sabbatical. While here, he developed a new way of aligning to millions of bacteria, called LexicMap 1/n www.nature.com/articles/s41...

nature.comEfficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature BiotechnologyLexicMap uses a fixed set of probes to efficiently query gene sequences for fast and low-memory alignment.

Richard Neher reposted

Join us for an exciting #BiozentrumDiscovery lecture! Prof. Tami Lieberman from @mit.edu will speak about the dynamic selective landscape of human microbiomes. Her lab studies microbial evolution in real time, with a focus on mutations occurring within individual human microbiomes.

Richard Neher reposted

Richard Neher reposted

Super excited that our group will be supported by an ERC Starting Grant! In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions. We'll have PhD and Postdoc positions available, please get in touch if interested!

Biozentrum, University of Basel@biozentrum.unibas.ch

Why do some cells become neurons and others muscle? Physicist Prof. David Brückner @davidbrueckner.bsky.social @biozentrum.unibas.ch @unibas.ch receives a prestigious #ERCStartingGrant to uncover how cells make life-shaping decisions. @erc.europa.eu www.biozentrum.unibas.ch/news/detail/...

Richard Neher reposted

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This wide-spread homologous recombination seems to happen despite often substantial divergence >5% between genomes. But sometimes populations seem to fragment into groups with much less exchange – whether this is driven by geographic separation, ecological factors, or divergence is unclear. [5/6]

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Using these cluster-wide pangenome graphs, we find a strongly conserved synteny of core phams. Accessory genome diversity is typically concentrated in well defined hotspots. [3/6]

Within the syntenic core genome, linkage between SNPs decays rapidly with distance. LD approaches background levels after about 1000 bases. The background level itself is often set by population structure with little linkage within subgroups but genome wide coupling across subgroups. [4/6]

Phages are known to recombine with each other and have flexible and fluid genomes. We analyzed diversity within the clusters of the Acinetobacteriophage Database by organizing their genomes into pangenome graphs based on homologous phams (protein families). [2/6]

Richard Neher reposted

Richard Neher reposted

A fascinating SARS-CoV-2 sequence was recently uploaded—collected from a dog in Kazakhstan in July 2022. Usher puts the sequence one nuc mutation from the Wuhan reference (C21846T, S:T95I)—i.e. pre-D614G. Could this sequence somehow have a close connection to the first days of the pandemic? 1/18

Richard Neher reposted

I have never seen anything like this in NYC. 5th Ave covered from 42nd St well to the 20s. Nobody prepared for this volume. Volunteers are holding the traffic on all the side streets. No police in sight. #handsoff

Mor Naaman@informor.bsky.social

Fifth Ave jammed #handsoff

Richard Neher reposted

Mr. Trump, this statute at the National Museum of African American History and Culture does not "undermine the remarkable achievements of the United States". It does not "fosters a sense of national shame." It does not "advance a corrosive ideology." It is literally what might redeem the USA.

From my colleague @cellarchlab.com and his lab at the @biozentrum.unibas.ch I continue to be amazed by what cyro-electron tomography can do...

Science Magazine@science.org

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion. Learn more: scim.ag/41PWgYc

5 years ago, I subscribed to Eco di Bergamo and spent a few hours counting obituaries in Feb/March. Most cases in northern Europe at the time were travel returnees that didn't get very sick, but the 7x increase in mortality in Bergamo left no doubt what happens if the virus hits the vulnerable.

Numbers came down quickly in early April, but the excess deaths accumulated through March corresponded roughly to the number of people that normally die in half a year.