RyanLab_TCD

RyanLab_TCD

@ryanlab.bsky.social

Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪

1.2K followers1K following271 posts

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RyanLab_TCD
@ryanlab.bsky.social

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...

nature.comAn inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature CommunicationsInherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...

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Shai Bel (The Mucus Man)
@mucusman.bsky.social

🚨🚨 When we take antibiotics we assume they'll kill the bad bugs but won't affect us directly. In our new story @NatureMicrobiol , we found that's not always the case and developed a tool, CompoRes, to identify these direct effects on the host /1 www.nature.com/articles/s41...

nature.comDisentangling microbiota-dependent and -independent impacts of antibiotics on host physiology - Nature MicrobiologyUsing a computational tool called CompoRes, the authors show that antibiotics can alter feeding behaviour, immunity and circadian regulation, revealing a non-microbial pathway by which antibiotic trea...

RyanLab_TCD reposted

Angelo D’Alessandro
@dalessandrolab.bsky.social

500 million people - 6% of humanity -are G6PD deficient. G6PD is key to cancer, aging & exercise, but >230 variants remain poorly understood. New preprint: “Structural divergence of G6PD variants shapes red blood cell storage and transfusion performance” www.biorxiv.org/content/10.1...

biorxiv.orgStructural divergence of G6PD variants shapes red blood cell storage and transfusion performanceGlucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy, yet how donor alleles shape red blood cell (RBC) storage, transfusion performance, and recipient physiology remains ...

RyanLab_TCD reposted

Ivan Zanoni
@lozanzi.bsky.social

#WeekendRead! #RememberMe! @khannakm.bsky.social @payalyokota.bsky.social &co show @nature.com that previous parasite lung infections drive chormatin programs in nerve-associated macrophages fostering type 2 & repair programs, protecting against subsequent lethal influenza infections!

nature.comType 2 immune history trains lung macrophages for viral disease tolerance - NatureType 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...
RyanLab_TCD
@ryanlab.bsky.social

🚨 We’re hiring a postdoctoral research associate! This is a great opportunity for scientists with a PhD interested in mitochondrial biology, immunometabolism, or primary mitochondrial disease. For more information email: ryand67@tcd.ie and include your CV and cover letter

RyanLab_TCD reposted

Trends in Endocrinology and Metabolism
@cp-trendsendomet.bsky.social

Online Now: Mitochondria produce lactate to vent redox pressure #trends #endocrinology #metabolism

dlvr.itMitochondria produce lactate to vent redox pressureConventionally viewed as a waste product or a cytosolic pyruvate source, recent findings suggest that lactate may also directly contribute to mitochondrial oxidative metabolism. Using an intramitochondrial lactate biosensor, Rauseo et al. instead find that energized mitochondria are producers of lactate, which buffers mitochondrial redox to mitigate reactive oxygen species production.

RyanLab_TCD reposted

Catalina Vasilescu, PhD
@cvasilescu.bsky.social

New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite www.nature.com/articles/s41... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social

nature.comMitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Naturel-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

RyanLab_TCD reposted

Cell Chemical Biology
@cp-cellchembiol.bsky.social

Identification of an STING inhibitor targeting the allosteric transmembrane domains

dlvr.itIdentification of an STING inhibitor targeting the allosteric transmembrane domainsChen et al. introduce Y-320, a potent allosteric STING inhibitor that uniquely binds to the transmembrane domain instead of the canonical binding pocket, thereby blocking STING activation and trafficking. Y-320 effectively improves acute kidney injury in mice, highlighting the therapeutic potential of targeting non-canonical STING sites.
RyanLab_TCD
@ryanlab.bsky.social

🚨 We’re hiring! 🚨 1/n I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️ Please share widely and see below for app details ⬇️

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RyanLab_TCD
@ryanlab.bsky.social

4/n The post is funded by a Wellcome Trust Career Development Award and would be particularly suited to someone to pursue a PhD. 📍 Location: Trinity Biomedical Sciences Institute, Trinity College Dublin 📅 Anticipated start: Flexible, ideally September 2026 ⏰ Closing date: 12 noon, 15 June 2026

RyanLab_TCD
@ryanlab.bsky.social

5/n Please share widely — and do get in touch if you know someone who might be a great fit! For details on how to apply see below: my.corehr.com/pls/trrecrui... #ResearchAssistant #Immunology #Mitochondria #Immunometabolism #InfectionBiology #PrimaryMitochondrialDisease #TrinityCollegeDublin

RyanLab_TCD
@ryanlab.bsky.social

🚨 We’re hiring! 🚨 1/n I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️ Please share widely and see below for app details ⬇️

RyanLab_TCD
@ryanlab.bsky.social

2/n This is a great opportunity for an early-career researcher interested in mitochondrial biology or immunology. The role will initially focus on primary macrophages from mitochondrial disease models to understand how pathogenic mtDNA mutations reshape cellular metabolism and innate immunity.

RyanLab_TCD
@ryanlab.bsky.social

3/n The successful candidate will gain hands-on experience across areas such as: 🧫 Primary macrophage culture 🧬 Molecular biology and genotyping 🔥 Inflammatory and infection-associated assays 📊 Metabolic and immunological readouts 🔬 A growing programme in mitochondrial immunometabolism

RyanLab_TCD
@ryanlab.bsky.social

I’m delighted to share this news and grateful to the @wellcometrust.bsky.social for supporting our work. We will soon be recruiting for both a Research Associate and Research Assistant position. More details will follow shortly, but please feel free to get in touch! www.tcd.ie/news_events/...

tcd.ieTrinity scientist aims to demystify debilitating inherited conditions and pinpoint new treatment optionsDr Dylan Ryan will pursue the research after securing a highly competitive Wellcome Career Development Award valued at around €2.5 million.

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Magdalena Skipper
@magdalenaskipper.bsky.social

Is there life on Mars? Organic molecules from clay-bearing sandstones found by the Sample Analysis at Mars instrument suite onboard the Curiosity rover 🧪 @natcomms.nature.com www.nature.com/articles/s41...

nature.comDiverse organic molecules on Mars revealed by the first SAM TMAH experiment - Nature CommunicationsCuriosity detected over 20 organic molecules in 3.5-billion-year-old Martian rocks using a wet chemistry experiment, showing complex carbon compounds can survive for billions of years and may preserve...
RyanLab_TCD
@ryanlab.bsky.social

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️ biomed.news/bims-imicid/... Lot's of exciting findings! 1) Purine salvage pathway protects CD8+ T cells from metabolic stress 2) Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells

RyanLab_TCD reposted

Ivan Zanoni
@lozanzi.bsky.social

#WeekendRead! #SharingIsCaring! #CatchMeIfYouCan! Roska, Ayupov, Moreno-Juan &co show @nature.com that healthy #mitochondria can be efficiently delivered to distinct cell types via a selective #MitoCatch system that allows their intracellular transfer & protection of cells!

nature.comCell-type-targeted mitochondrial transplantation rescues cell degeneration - NatureMitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

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Nature Portfolio
@natureportfolio.nature.com

In its 2025 PhD survey, Nature asked more than 3,700 doctoral candidates around the world a simple question: what is the best thing your supervisor has done for you during your studies? Nature highlights several moments when good supervision made the difference. #Academicsky 🧪

go.nature.com14 things our PhD supervisors got right and why it matteredPhD students reflect on how their supervisors made a meaningful difference — from quiet acts of kindness to career-shaping guidance.

RyanLab_TCD reposted

Ivan Zanoni
@lozanzi.bsky.social

#WeekendRead! #ViromePower! Lin, Li &co show @cp-cellhostmicrobe.bsky.social that the virome regulates sugar digestion & absorption by intestinal epithelial cells #IECs by favoring production of IL-22 via an antigen presenting cell-#Th17 axis!

sciencedirect.comCommensal enteric virome regulates intestinal carbohydrate digestion and absorptionThe enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various…