The Dillard Lab is looking to hire a research technician to study the mechanisms by which Neisseria gonorrhoeae damages human Fallopian tubes during pelvic inflammatory disease. Lab website: www.dillardlab.mmi.wisc.edu View the job posting: shorturl.at/YO2sE
Joe Dillard
Joe Dillard
@sacculus.bsky.social
Bacteriologist. We study Nesseria, Gardnerella, and all things related to peptidoglycan. Professor at UW-Madison.
885 followers639 following43 posts
Joe Dillard reposted
Spanish government launches a plan to study women’s health, which has been so neglected 👏🏼👏🏼 El gobierno lanza un plan para apoyar la investigación sobre la salud de la mujer, tan abandonada hasta ahora elpais.com/salud-y-bien...
Joe Dillard reposted
The #WHO just released recommendation of #doxyPEP for #STI prevention among MSM and transgender women Monitoring of #AMR also recommended Research gaps still remain, including long-term impacts on AMR/microbiome and effectiveness in different settings www.who.int/teams/global... #STIsky
Joe Dillard reposted
I'm convening a session at ASM Microbe 2026 on vaginal infections. Come learn about the great recent advances in research on Gardnerella, Sneathia, Group B Strep, and Candida infections. #ASMicrobe invt.io/1bxbqiyuh8c
Joe Dillard reposted
Out Now! Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae #MicroSky
Joe Dillard reposted
Exciting research here on the development and lab evaluation of #CRISPR #POC tests for #STIs (chlamydia, gonorrhea, syphilis, HSV 1 /2) Also very interesting they could detect S91F to predict cipro resistance in #gonorrhea POC tests for STIs can be game-changers in many settings #STIsky #IDsky
New research article CRISPR-Cas-based diagnostics for point-of-care detection of sexually transmitted infections: a laboratory development and evaluation study www.thelancet.com/journals/lan... #IDSky #ClinMicro #STI #OpenAccess #OA
Dr. Cole's presentations at the Neisseria meetings were delightful. So sorry he is gone.
It is with deep sadness that we share the passing of Professor Jeff Cole. An esteemed academic, Jeffs research on bacterial adaptation to oxygen and nitrosative stress made a lasting impact on the field. He mentored nearly 60 doctoral students, our thoughts are with his family, friends & colleagues
Joe Dillard reposted
This is a great @cidjournal.bsky.social supplement for all you #gonorrhea, #STI, and #AMR enthusiasts. Or for anyone who’s heard about drug-resistant gonorrhea and wants to learn more. Will link articles in 🧵 below - check it out and share! #openaccess #IDsky #STIsky bsky.app/profile/carb...
📘 New publication supported by CARB-X! A new supplement in Oxford University Press Clinical Infectious Diseases highlights why treatment diversification is essential to address rising drug resistance in N. gonorrhoeae. #IDSky 🧪 🔗 Read here: bit.ly/45KVg90
Joe Dillard reposted
We mapped the whole human fallopian tube in 3D and at single-cell resolution via our CODA workflow. More about this work here: biorxiv.org/content/10.1...
Joe Dillard reposted
Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...
Joe Dillard reposted
A Lyt at the end of the tunnel? Unraveling the complex interactions of the N-acetylglucosaminidase LytG in cell wall metabolism RSC Chemical Biology pubs.rsc.org/en/content/a...
Joe Dillard reposted
STD cases have fallen, but not syphilis in newborns. Data for 2024 from the CDC showed a 3rd consecutive year of fewer gonorrhea cases & the 2nd year of fewer adult cases of chlamydia & the most infectious form of syphilis. However, congenital syphilis cases aren't seeing the same improvements👇
Joe Dillard reposted
Cool work by @mkjos.bsky.social Daniel Straume showing that the competence-induced peptidoglycan hydrolase LytF promotes pilus extrusion, thereby enhancing the efficiency of DNA uptake in S, sanguinis. Is this also a major function of the pneumococcal CbpD fratricide? www.biorxiv.org/content/10.1...
Joe Dillard reposted
Uropathogenic #Ecoli #UPEC proliferate as round coccoid cells during intracellular infection; @alaskapokhrel.bsky.social @bill-lab.bsky.social &co show that accelerated division via FtsZ constriction drives this, the coccobacillus form persisting for generations @plosbiology.org 🧪 plos.io/4gdx97i
Our paper describing transformation of Gardnerella species is published in Infection and Immunity. We think this will lead to further molecular studies of bacterial vaginosis and potential therapeutics. journals.asm.org/doi/10.1128/...
Joe Dillard reposted
This first-author publication is my… first! Archaea kill bacteria by targeting their Achilles’ heel: peptidoglycan. Big shoutout to @ahocher.bsky.social, @valeriesoo.bsky.social, Pauline Misson, @tobiaswarnecke.bsky.social and MRC LMS Proteomics. A thread 🔽 journals.plos.org/plosbiology/...
Joe Dillard reposted
Bacterial cell wall & periplasm paradigm shift - important read #MicroSky www.nature.com/articles/s41...
#microsky We challenge the long-standing view that peptidoglycan alone protects cells from bursting. Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria. 📄 www.nature.com/articles/s41...
Joe Dillard reposted
Thrilled to share the first preprint from my group! Prevotella are predominant but understudied members of the respiratory microbiome. They have a reputation for being hard to work with, but understanding them is likely important for understanding how they contribute to respiratory health. 🧫🔬
Development of a basal media for carbon utilization assay and analysis of the starch utilization locus in Prevotella melaninogenica https://www.biorxiv.org/content/10.1101/2025.07.04.663206v1
I wrote a preview for Cell Host & Microbe about the article from Kurt-Jones et al. on IFN-epsilon enhancement of gonococcal infection. One cool facet of this work is that it provides a possible mechanism for Chlamydia to increase gonococcal co-infection. www.cell.com/cell-host-mi...
Kurt-Jones et al. show that IFN-epsilon increases production of CMP-sialic acid from epithelial cells, allowing gonococci to add sialic acid to their lipooligosaccharide and become resistant to an antimicrobial peptide. www.cell.com/cell-host-mi...
Joe Dillard reposted
Very happy to share that a large part of my thesis work is out today: B. subtilis uses the second messenger c-di-AMP to modulate its turgor pressure in response to the state of its cell envelope. www.nature.com/articles/s41...
Checkout out our preprint describing mutagenesis methods for Gardnerellla species. We showed that a vaginolysin mutant was defective in lysing cervical cells in human cervix explants and that a sialidase mutant was deficient in degrading human cervical mucus. www.biorxiv.org/content/10.1...
Checkout out our preprint describing mutagenesis methods for Gardnerellla species. We showed that a vaginolysin mutant was defective in lysing cervical cells in human cervix explants and that a sialidase mutant was deficient in degrading human cervical mucus. www.biorxiv.org/content/10.1...
Checkout out our preprint describing mutagenesis methods for Gardnerellla species. We showed that a vaginolysin mutant was defective in lysing cervical cells in human cervix explants and that a sialidase mutant was deficient in degrading human cervical mucus. www.biorxiv.org/content/10.1...
Checkout out our preprint describing mutagenesis methods for Gardnerellla species. We showed that a vaginolysin mutant was defective in lysing cervical cells in human cervix explants and that a sialidase mutant was deficient in degrading human cervical mucus. www.biorxiv.org/content/10.1...
Joe Dillard reposted
Our review on Z-ring placement mechanisms in cocci is out! This was a fun one to write! #Microsky 🦠🧫
Cell division in rod-shaped bacteria is well studied (think "Min system"), but how do round bacteria find their middle? @felixrl.bsky.social 's new review article covers how #Staph aureus, Streptococci, and others figure out how to perform binary fission. portlandpress.com/biochemsoctr...
Joe Dillard reposted
dx.plos.org/10.1371/jour... #MicroSky
Joe Dillard reposted
So…um…who is doing the testing for multi drug resistant gonorrhea and resistant trichomonas ????
Labs at CDC investigating STD and hepatitis outbreaks have now been cut, as part of Secy Kennedy's layoffs Specimens were still arriving from state health departments, with no one left on job from labs to handle them "The outbreak detection is gone" www.cbsnews.com/news/rfk-jr-...
Joe Dillard reposted
Work of our lab @univie.ac.at in close collaboration with the Hauck Lab @uni-konstanz.de was published in @naturemicrobiol.bsky.social today. A compound highly selective in targeting Neisseria gonorrhoeae using a novel mode of action. @cemess.bsky.social medienportal.univie.ac.at/en/media/rec...
Joe Dillard reposted
(1/10) New preprint: Expansion of tetM-carrying Neisseria gonorrhoeae in the US, 2018-2024; Link: www.medrxiv.org/content/10.1...
Joe Dillard reposted
I’m very happy to share our latest work on the ParABS system. We investigated the dynamic interaction between the ATPase ParA and the CTPase ParB mediating chromosome segregation in Myxococcus xanthus. I would like to thank all the people involved.
Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation https://www.biorxiv.org/content/10.1101/2025.03.14.642875v1
Joe Dillard reposted
Joe Dillard reposted
Potential Impact of Doxycycline Post-Exposure Prophylaxis on Tetracycline Resistance in Neisseria gonorrhoeae and Colonization with Tetracycline-Resistant Staphylococcus aureus and Group A Streptococcus ✅ Just Accepted #IDSky
Joe Dillard reposted
Europe reports surging STIs, including #AMR gonorrhea, alongside FDA approval of a new antibiotic and WHO’s AMR research priorities, stressing urgent global action. Related updates (mpox, dengue, COVID) underscore need for coordinated innovation and stewardship. www.cidrap.umn.edu/sexually-tra...
Joe Dillard reposted
New preprint 🚨: with @madejmar.bsky.social we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. www.biorxiv.org/content/10.1... #cryo-EM
Joe Dillard reposted
#Neisseria gonorrhoeae evades immunity by altering its surface structures. @maierlab.bsky.social &co show that this process also modulates bacterial interactions, driving microcolony diversification, aggregation, colony morphology & #antibiotic tolerance 🧪 @plosbiology.org plos.io/4aN1zdO
Joe Dillard reposted
New paper out today from the lab on Akkermansia muciniphila 🦠and how it breaks down host glycans! Very proud of my group, especially @cassiebakshani.bsky.social who did an amazing job. @naturemicrobiol.bsky.social www.nature.com/articles/s41...
Joe Dillard reposted