Michael

Michael

@schlierflab.bsky.social

single-molecule aficionado, antibiotic resistances Prof at TUD @tudresden.bsky.social Alum: UIUC, TUM @tum.de, LMU @lmumuenchen.bsky.social, U Paris XI

534 followers389 following48 posts

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Our newest bioRxiv on the bacterial integron is out (link below). 🧑‍🔬 How it started: Rising #AMR are a challenge for health. A key player is the bacterial integron. Do you remember its recombination efficiency 🧬🧬 correlated with the mechanical stability 💪 of a recombinase-DNA complex? 1/6

Michael reposted

Join #MSc Physics of Life @tudresden.bsky.social and help shape the future of #Biophysics! Learn from the world-class scientists of the CMCB and @poldresden.bsky.social More about the program ➡️ tud.link/3wz553 Don't miss the testimonials from our graduates ⤵️ #studyinGermany #MastersProgram

youtube.comStudy Physics of Life at the CMCB, TU Dresden - Testimonial - Hamza, Part 1YouTube video by Center for Molecular and Cellular Bioengineering

aCOS is a spectroscopy-based technique to determine affinities between molecules, e.g. small molecules and targets, or between two or more interaction partners leveraging the change of complementary fluorescence spectroscopy parameters upon binding or dissociation.

Congratulations 🎉 to Karl-Ludwig for his successful PhD defense about structural changes within the endosomal tethering protein EEA-1. Stay tuned - manuscript in prep 💽 ✍️🧑‍💻

Congratulations to Lukas @pekarekl.bsky.social for winning the poster prize at the DGfB Molecular Biophysics meeting in Hünfeld last week 🏆 - it was a fantastic meeting with lots of interesting talks & great to catch up with colleagues and sad that we missed out on many of our Israeli colleagues.

Our newest bioRxiv on the bacterial integron is out (link below). 🧑‍🔬 How it started: Rising #AMR are a challenge for health. A key player is the bacterial integron. Do you remember its recombination efficiency 🧬🧬 correlated with the mechanical stability 💪 of a recombinase-DNA complex? 1/6

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This was a new adventure for us to develop an assay to stress bacteria 🧫 and test how good they adapt to antibiotic stress. We stress bacteria 🦠 with e.g. Ciprofloxacin and see if they adapt via a provided mobile integron system ± peptide. We determine many factors using also microscopy… 5/

Our newest bioRxiv on the bacterial integron is out (link below). 🧑‍🔬 How it started: Rising #AMR are a challenge for health. A key player is the bacterial integron. Do you remember its recombination efficiency 🧬🧬 correlated with the mechanical stability 💪 of a recombinase-DNA complex? 1/6

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… use this to find a small molecule, which inhibits tail binding and thus destabilises the complex and reduces the ability to adapt to antibiotic stress in bacteria? Yes, and Kate 👩‍🔬 came up with a few different peptides … and we can control destabilisation … 3/

…modify single amino acids to gain or lose function. It is dose dependent and works with a peptide as short as 7 aa. But wait 🫷- does it also work in bacteria? 4/

Our newest bioRxiv on the bacterial integron is out (link below). 🧑‍🔬 How it started: Rising #AMR are a challenge for health. A key player is the bacterial integron. Do you remember its recombination efficiency 🧬🧬 correlated with the mechanical stability 💪 of a recombinase-DNA complex? 1/6

DNA elements were important for mechanics, but also protein mutations decreased recombination significantly. In particular the C-terminal extensions (the little pig-like ;) tails linking IntI1) stabilised the complex significantly and truncation reduced recombination. Hm💭 - could we maybe … 2/

Exciting times and new ideas to address the rise of AMR bacteria - looking forward to see how far we can push this idea with the support of the GO-Bio program.

🦠 Antibiotic resistance is a growing global challenge 🌍. With support from the GO-Bio program (BMFTR), Dr. Ekaterina Vorobevskaia & Prof. Michael Schlierf @schlierflab.bsky.social are taking the next step to develop new tools against multiresistant bacteria. 🔬🧪 Read more: tud.link/q66rj1

Michael reposted

Deadline is approaching (Feb 9) to apply for a PI position at Institut Pasteur. Come join us and contribute to an amazing scientific environment!!!

We are looking for a new technician 🥼 - initially limited with the option to a permanent position. If you are interested in molecular biology🧫, biochemistry🧬, a dynamic🕺, international🌍, welcoming science enthusiasts 🧑‍🔬 take a closer look👇 - Re-post appreciated www.verw.tu-dresden.de/StellAus/ste...

verw.tu-dresden.deVacancy ID 12501Am Center for Molecular Bioengineering (B CUBE), einem Institut des Center for Molecular and Cellular Bioengineering (CMCB), ist an der Professur für Molekulare Biophysik ab sofort eine Stelle als

Oh this looks 🤩. #smFRET Thanks for making all these efforts to outreach. In case anyone has questions, please do not hesitate to contact me. 📝🧑‍💻

GdR ImaBio 🔬@gdrimabio.bsky.social

Michael SCHLIERF @schlierflab.bsky.social's lecture is online ! 👉 "Large Throughput Single-Molecule FRET to Study Protein Structure and Dynamics" 👉 youtu.be/WHCGmtLTkEs @tudresden.bsky.social @tum.de @lmumuenchen.bsky.social @cnrsingenierie.bsky.social @cnrs.fr #Mifobio2025 #GDRImabio

3 more days to apply for a PhD position within our training program on biomolecular condensates 👇👇. 12 positions within our a focus from physics and theory to experimental biophysics to biology and medicine/disease.

Michael@schlierflab.bsky.social

Are you interested in Biomolecular Condensates and looking for a PhD training? Check out the 12 (!) open PhD positions (also 1 on smFRET & condensates 🙃) in Dresden @rtg3120.bsky.social @tudresden.bsky.social starting April 2026. Apply latest by 24 Oct 2025 here: dresdencondensates.org/join-us/

Au revoir #mifobio2025. It was a fantastique, inspiring meeting- merci beaucoup for the invite and the great organization and all the workshops from homebuilt microscopes to the newest company developments. 🤩

Michael@schlierflab.bsky.social

I am very much looking forward to an inspiring week at #Mifobio2025 - thanks for the invite! I am counting on learning new exciting (pun intended) insights on fluorescence and happy to share our experience and vision on large throughput #smFRET .

I am very much looking forward to an inspiring week at #Mifobio2025 - thanks for the invite! I am counting on learning new exciting (pun intended) insights on fluorescence and happy to share our experience and vision on large throughput #smFRET .

GdR ImaBio 🔬@gdrimabio.bsky.social

Let's explore the #Mifobio2025 programme ! 👉 "Focus On” : “Single Molecule Fluorescence Microscopies for Drug Discovery” ✨ We are delighted to welcome @schlierflab.bsky.social 🎤 Lecture : Large Throughput Single-Molecule FRET to Study Protein Structure and Dynamics 👉 imabio-cnrs.fr #GDRimabio

Michael reposted

🔬For 22 years, we have been organizing #Mifobio "Functional Microscopy for Biology" the @cnrs.fr thematic school. 🎓 Courses, Seminars, Round Tables, Workshops. The overall theme concerns #biological_imaging in its most interdisciplinary aspects. 👉 Program: imabio-cnrs.fr #GDRImaBio #Mifobio2025

Michael reposted

Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!

John Innes Centre@johninnescentre.bsky.social

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...

Michael reposted

🚨 Open PhD Position! We're looking for a PhD candidate to join our group and develop single-molecule fluorescence assays for protein biophysics. 🔬 Candidates with experience in smFRET and Python proficiency are particularly encouraged to apply! 📄 More info: euraxess.ec.europa.eu/jobs/333875

lnkd.inLinkedInThis link will take you to a page that’s not on LinkedIn
Georg Krainer@georgkrainer.bsky.social

🚨 PhD Opportunity in Single-Molecule Biophysics (ERC-Funded) at the University of Graz! 🚨 📄 More details in the flyer below and on: euraxess.ec.europa.eu/jobs/333875 🔗 molecular-biophysics.uni-graz.at/en/

Michael reposted

Happy to be part of the Dresden Science Night at the CMCB! The B CUBE was well-represented with @schlierflab.bsky.social, @stefandiezlab.bsky.social, @jamessaenz.bsky.social group as well as Kröger and Politi groups! 🙏🏻 Big thanks to everyone taking part in the event!

🌙 Over 2,200 visitors, 250+ volunteers, and one unforgettable Science Night at the CMCB, @tudresden.bsky.social! Huge thanks to everyone who joined us – and to our amazing volunteers! #LNDWDD #Dresden #CMCBnews

JOB OPENING for biochemist/-physicst 🧑‍🔬: This isn't an official job ad yet. We are looking for a postdoc working on large to high throughout single-molecule FRET on protein structures and dynamics. The project will be run in our lab and co-directed jointly with a team from big pharma/biotech. 1/2

Experience with HEK293 or similar expression very helpful, smFRET nice to have though we can teach that ;). Great project to have a look at the academia and industry world. 👀 Interested candidates please write me an email with motivation and CV. Starting in autumn 2025. Please re-post. 2/2

Fantastic success and happy to see the biophysics community strong @tudresden.bsky.social with the renewal of @poldresden.bsky.social ! 🎉🥂 BTW: 8 days left to apply for our master program MSc Physics of Life :)

TU Dresden@tudresden.bsky.social

Outstanding success: 🎉 #TUDresden shines with 5 Clusters of Excellence. @dfg.de & @wissenschaftsrat.de announced that decision today. TUD has impressively proven its claim to be a top university for the 21st century. ℹ️ tu-dresden.de/tu-dresden/n...

Michael reposted

At least 10% of the V. cholerae integron cassettes have novel antiphage activities (see below). Considering that there are 25,000 distinct cassettes of unknown function, integrons constitute an extraordinary and almost inexhaustible reservoir of antiphage functions!

science.orgSedentary chromosomal integrons as biobanks of bacterial antiphage defense systemsIntegrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

Michael reposted

Michael reposted

🧬🔬 Study biophysics in Dresden! Enroll in Physics of Life MSc @cmcb-tud.bsky.social @tudresden.bsky.social and secure your chance for a scholarship ⤵️

Good news: there will be 3 scholarships available for Physics of Life MSc students starting in 2025! ✅ €300/month for 1 year ✅ No separate application—admitted students are automatically considered. Apply now ➡️ tud.link/vejrmx #Biophysics #PhysicsofLife #StudyinGermany #Masters #Biology

Michael reposted

Applications for the international 'Physics of Life' MSc are open until 31. May! This year, 3 students will receive #scholarships for the first year of their studies. This is an excellent opportunity for #internationalstudents, please share with your colleagues! #mastersprogram #msc #studyabroad

Good news: there will be 3 scholarships available for Physics of Life MSc students starting in 2025! ✅ €300/month for 1 year ✅ No separate application—admitted students are automatically considered. Apply now ➡️ tud.link/vejrmx #Biophysics #PhysicsofLife #StudyinGermany #Masters #Biology