Schwalbe Lab

links.springernature.comIntegrative biophysical illumination of the 3D GPCRome dynamics - Nature Structural & Molecular BiologyMedel-Lacruz et al. introduce GPCRmd-NMR, an open platform that links molecular simulations with nuclear magnetic resonance (NMR) spectroscopy to uncover hidden conformational dynamics across G-protei...

10m

Check out this amazing new publication "Integrative biophysical illumination of the 3D GPCRome dynamics" in #NSMB by Medel-Lacruz et al. Full text: links.springernature.com/f/a/WqRpBfOR...

doi.orgTime‐Resolved Multidimensional NMR Spectroscopy Reveals the Bifurcated Folding Pathway of a Thrombin‐Binding DNA G4–Azobenzene Derivative ComplexA photoswitchable ligand was used to trigger conformational changes within the thrombin binding aptamer DNA G-Quadruplex. These reversible ligand driven rearrangements were examined by time-resolved ...

New publication in #AngewandteChemie International Edition from our lab! Time‐Resolved Multidimensional NMR Spectroscopy Reveals the Bifurcated Folding Pathway of a Thrombin‐Binding DNA G4–Azobenzene Derivative Complex Full text: doi.org/10.1002/anie...

Today, the Meeting of Instruct-ERIC Council Takes place at the University of Florence. The Council discusses the shape of Instruct-ERIC from 2028-2032.

Instruct director Prof. Harald Schwalbe visits the structural biology Community in Japan at Riken Yokohama.

NMR of RNA @Riken, Japan. By P. Wurm from Bruker

Prof. Harald Schwalbe, director of Instruct-ERIC, visiting the structural biology community in France at the annual meeting of FRISBI in Gif-sur-Yvette.

Celebrating the decision of Wissenschaftsrat and DFG to make the Rhine/Maine-Universities Mainz, Frankfurt and Darmstadt to a Excellence University cluster.

Registration for the G4thering opened TODAY! The 10th international meeting on G4 structures will take place in Frankfurt, Germany from August 3rd to August 7th 2027. The first 30 PhD students to register will get an additional 100€ discount on early bird registration fees! #G4thering #G4

hessenschau.deAus Sorge vor Trump und Co.: Frankfurter Uni sichert ForschungsdatenAn der Frankfurter Goethe-Universität entsteht eine Datenbank für Forschungsdaten zur Entwicklung von Medikamenten. Sie sollen so vor Verlust und Einflussnahme von außen geschützt werden. Entwicklunge...

Harald Schwalbe spricht über das Projekt BMRBe und die Bedeutung resilienter Forschungsdaten. Die an der Goethe-Universität entstehende europäische Datenbank soll NMR-Forschungsdaten langfristig sichern und freien Zugang zu wissenschaftlichen Daten gewährleisten. www.hessenschau.de/gesellschaft...

academic.oup.comMolecular structure and DNA binding mode of unsymmetric cyanine dyes RiboGreen and OliGreenAbstract. The binding of fluorescent dyes to nucleic acids and their fluorogenic properties are indispensable tools for nucleic acid detection, quantificat

New paper in @narjournal.bsky.social by Robert Silvers and colleagues! The study reveals the molecular structures and nucleic acid binding modes of the widely used dyes RiboGreen, OliGreen and PicoGreen using NMR spectroscopy and high-resolution MS. Full text: academic.oup.com/nar/article/...

gdch.deAlbert-Overhauser AwardThe Albert-Overhauser Award honours outstanding achievements in magnetic resonance and shares information about GDCh Division awardees.

22 Sept

Congratulations to Dr. Fabian Hecker (Technical University of Denmark (DTU)) on receiving the Albert-Overhauser Prize of the GDCh Division of Magnetic Resonance! 🎉 A well-deserved recognition of outstanding research in magnetic resonance. Further Info: www.gdch.de/en/divisions... #NMR #GDCh

onlinelibrary.wiley.comSmall Molecule Modulation of TERRA RNA Quadruplex Reprograms ALT‐Telomere MaintenanceThe telomeric lncRNA TERRA forms RNA G-quadruplex structures that regulate telomere integrity. An indoloquinoxaline ligand (IQ4) selectively binds and stabilizes the TERRA rG4, disrupts the TERRA–TRF...

22 Sept

Another collaboration published! Have a look at this work on targeting TERRA RNA G-quadruplexes with small molecules and their role in ALT-associated telomere maintenance. Full text: onlinelibrary.wiley.com/doi/epdf/10.... #RNA #GQuadruplex #Targeting #NMR

18 Sept

Handing of the FEBS national lecturer medal to Prof. Martin Blackledge at the GBM Compact Workshop 2026 on RNA Structure and Dynamics in Frankfurt! @gbmev.bsky.social @febspress.bsky.social #GBM #FEBS #StructuralBiology

14 Sept

Visiting the Diamond Light Source Synchrotron at Harwell Campus, UK! Great discussions on collaborations connecting scientists from Turkey, the UK, and Instruct-ERIC. Looking forward to new opportunities for international collaboration! #synchrotron #collaboration #structuralbiology

1 Sept

We are delighted to share that Harald Schwalbe has been elected an ISMAR Fellow 2026. Congratulations to Martin Blackledge and Yoshitaka Ishii, who have also been elected as ISMAR Fellows! A wonderful recognition of their contributions to magnetic resonance and NMR research worldwide. 🎉 #NMR #ISMAR

28 Aug

What a great week at this year’s ICMRBS conference in Davos! 😊 Several members of our group had the opportunity to present their research, and it was a great chance to exchange ideas, discuss exciting science, and meet researchers from all over the world. #ICMRBS #Davos #conference #NMR

bruker.comNMR of Nucleic Acids

21 Aug

How to NMR with RNA? Together with @brukercorporation.bsky.social, we developed a practical tutorial on RNA NMR: from sample preparation and experiment setup to data analysis. A useful starting point for anyone getting into RNA NMR! www.bruker.com/en/products-... #RNA #NMR #StructuralBiology

currentprotocols.onlinelibrary.wiley.comIntegrative <i>in silico</i> and <i>in vitro</i> screening of small molecules targeting RNATargeting structured RNA elements with small molecules has emerged as a promising yet technically challenging strategy for antiviral drug discovery. Here, we present a comprehensive and experimentall....

21 Aug

We have just published a new protocol on integrative in silico and in vitro screening of small molecules targeting RNA! It combines virtual screening & NMR to identify and characterize RNA binders. currentprotocols.onlinelibrary.wiley.com/doi/10.1002/... #virtualscreening #NMR #RNA #targeting

cell.comFragment screening in focusIn this Voices article, participants from the recent wwPDB Workshop on Fragment Screening at the EMBL-EBI and their colleagues discuss recent advances, current challenges, and future opportunities in ...

7 Aug

Excited to contribute to the new Voices article on the future of fragment screening! Great to be part of this community effort. www.cell.com/structure/fu... #FragmentScreening #DrugDiscovery #StructuralBiology #NMR

uni-frankfurt.deHow Dangerous Bacteria Survive | Goethe University FrankfurtA collaborative team of scientists, including researchersGoethe University Frankfurt, has conducted research revealing how Streptococcus pneumoniae...

5 Aug

Based on our newest publication, there is a new article on the webpage of the @goetheuni.bsky.social 😍 www.uni-frankfurt.de/en/newsroom/... #bacteria #science

doi.orgStreptococcus pneumoniae substrate binding protein SatA specifically recognises the α-anomer of N-acetylneuraminic acid - Communications BiologyThe respiratory pathogen Streptococcus pneumoniae uses the substrate binding protein SatA of the ABC transporter SatBC–MsmK to specifically bind the α-anomer of N-acetylneuraminic acid, the immediate ...

29 July

Excited to see a new publication in Communications Biology! 🎉 Read it here: doi.org/10.1038/s420... #SialicAcid #StreptococcusPneumoniae #ABCTransporter #CarbohydrateTransport #StructuralBiology #Microbiology

Schwalbe Lab reposted

28 July

Great to be at the @eptri.bsky.social Scientific Meeting 2026 in Warsaw this week! Meet us for talks from Director Prof. Harald Schwalbe (@schwalbe-lab.bsky.social) on interactions with EPTRI, plus great contributions from Jan Pribyl of @ceitec.eu and Oksana Degtjarik of @astbury-bsl.bsky.social!

uni-frankfurt.deFrankfurt to Host International Bio Research DatabaseInternationally networked research database will collect structural data on biomolecules obtained worldwide through nuclear magnetic resonance (NMR) studies

6 July

@goetheuni.bsky.social is building BMRB Europe, an internationally connected NMR research database that will let data flow directly from spectrometers to the global research community, funded by the DFG. www.uni-frankfurt.de/en/newsroom/...

hessenschau.deInternationale Bio-Datenbank wird in Frankfurt aufgebautFinden Sie Berichte zu Unfällen, Kriminalität, Bränden und Katastrophen, aber auch Buntes aus der Region: Kuriositäten, Beiträge über hessische Promis oder besondere Leistungen einzelner Hessen. hesse...

27 July

BMRB Europe is making the news! Thanks to German news outlet @hessenschau.bsky.social for featuring the project and its role in strengthening open biomolecular NMR data. www.hessenschau.de/panorama/int...

nature.comAI-assisted fragment-based drug discovery of SARS-CoV-2 macrodomain binders validated by NMR and X-ray crystallography - Communications ChemistryArtificial intelligence and machine learning have recently accelerated fragment-based drug discovery (FBDD) processes through structure-based optimization and generative compound design. Here, the aut...

20 July

Check out our new publication out in @commschem.nature.com 😍 "AI-assisted fragment-based drug discovery of SARS-CoV-2 macrodomain binders validated by NMR and X-ray crystallography" Full text: www.nature.com/articles/s42... #FBDD #NMR #Xray #AI #SARS-CoV-2

Schwalbe Lab reposted

15 July

Dr Irene Bessi and Maria Greve of the Prof. Claudia Höbartner group at @uni-wuerzburg.de gave a seminar outlining Instruct-funded access to @goetheuni.bsky.social! Thank you to GUF and Christian Richter for assisting with the access! @schwalbe-lab.bsky.social instruct-eric.org/centre/bmrz-...

14 July

Instruct director Prof. Harald Schwalbe visited the CTB12 conference in Siena, giving the opportunity to exchange with colleagues to discuss their research at the interface of Chemistry, Biology and Structures. #structure #biomolecules #CTB12

chemistry-europe.onlinelibrary.wiley.comRapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon InclusionAn adaptable approach, many light-switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre-mRNA, restoring the leve...

14 July

Thanks for having us as collaborators on this! @olallalab.bsky.social Congrats to everyone involved in developing a platform for photoswitchable RNA binders, enabling light-controlled RNA modulation and RNA-targeted therapeutics. Full text: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

rnajournal.cshlp.orgIntegrated NMR/MD investigation reveals differences after reweighting in conformational ensembles of GAAG and GCAA tetraloops A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

1 June

New publication alert from our lab 💥☺️ "Integrated NMR/MD investigation reveals differences after reweighting in conformational ensembles of GAAG and GCAA tetraloops" Full text: rnajournal.cshlp.org/content/earl... #NMR #MD #RNA

Schwalbe Lab reposted

instruct-eric.orgInstruct-ERIC Biennial Structural Biology Conference 2026 - Instruct-ERICInstruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.

28 May

First talk by our director Prof Schwalbe @schwalbe-lab.bsky.social This conference is the opportunity to showcase integrated structural biology, we are now in our 7th edition. Tomorrow we will announce which Instruct country is hosting next! Read more here instruct-eric.org/ibsbc2026

Claudia Alen Amaro@claudialen.bsky.social

The @instruct-eric.bsky.social Biennial Structural Biology Conference #IBSBC2026 is underway today in Brussels Thanks to our hosts @jansteyaert.bsky.social and his team at the highly successful #Nanobodies4Instruct facility Learn all about is and apply to access instruct-eric.org

dfg.deDFG fördert 13 neue Sonderforschungsbereiche

15 May

Excited to share that our project (smART) has received funding approval from the German Research Foundation (DFG) as part of the latest funding round. We’re grateful for the support and looking forward to the next phase of exciting RNA research! 🥳 www.dfg.de/de/aktuelles... #Research #Funding #DFG

uni-frankfurt.deFunding for Three Collaborative Research CentresNew CRC/TRR 440 smART Develops mRNA Tools – Collaborative Research Centres 1507 and 1531 of the Rhine-Main Universities (RMU) on Cellular Supercomplexes and...

15 May

Also congrats to the other Goethe initiatives receiving further funding by the DFG! Strong recognition for Frankfurt research across mRNA biology, connective tissue, and protein complexes. www.uni-frankfurt.de/en/newsroom/...

Schwalbe Lab reposted

Deutsche Forschungsgemeinschaft

@dfg.de

15 May

Die #DFG fördert zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 13 neue #Sonderforschungsbereiche (SFB). Die Themen reichen von der Erforschung extraterrestrischen Lebens bis zu Papieranwendungen der Zukunft. Einzelheiten 👉 www.dfg.de/de/aktuelles/…

uni-frankfurt.deGoethe-Universität — Press releases

5 May

Our recent publication exploring how complexity and “emergence” in chemistry may help explain the transition from non-living to living matter is now featured in a press release by Goethe University Frankfurt! Press release: www.uni-frankfurt.de/press-releas... Publication: doi.org/10.1002/anie...

sciencedirect.comMoving NMR infrastructures to remote access capabilitiesTraditionally, Nuclear Magnetic Resonance (NMR) infrastructures have relied on in-person access, requiring researchers to travel to centralized facili…

4 May

Check out the new article: "Moving NMR infrastructures to remote access capabilities": www.sciencedirect.com/science/arti... #NMR #remote #datamanagement

academic.oup.comThe kinase inhibitor palbociclib binds to HIV TAR RNA with very low nanomolar affinity and exquisite specificityAbstract. We report that the kinase inhibitor Palbociclib is a very low nanomolar ligand for the HIV-1 TAR, a paradigmatic ‘difficult-to-drug’ RNA. Binding

30 Apr

Interesting back-to-back papers from the Varani Group in @narjournal.bsky.social showing that an approved kinase inhibitor can specifically bind the HIV-1 TAR RNA element and influence its downstream function. A promising direction! academic.oup.com/nar/article/... academic.oup.com/nar/article/...

academic.oup.comStructure and sequence characteristics of 5′-stem-loop 1 modulate the escape from nsp1-mediated repression in SARS-CoV-2 variantsAbstract. Several SARS-CoV-2 variants have evolved with clinical relevance due to their structural and functional impact on viral proteins and genomic RNA

30 Apr

Excited to see this work out in @narjournal.bsky.social! Our collaborators @weigandlab.bsky.social dissect how SARS-CoV-2 5'-UTR RNA structures and nsp1 protein variants co-evolve to control viral translation. We were glad to contribute to parts of this project! academic.oup.com/nar/article/...

chemistry-europe.onlinelibrary.wiley.comDissecting the Chemical and Thermal Stabilities of Tetrads in G‐Quadruplexes to Derive a Structure‐Activity Relation for a Thrombin‐Binding DNA G‐Quadruplex AptamerExtended variants of the G-quadruplex thrombin binding aptamer exhibit differential anticoagulation activities. We show that 3’ terminal extensions increase nuclease resistance, while variations in t....

24 Apr

A new publication on G4s is online 💥 "Dissecting the Chemical and Thermal Stabilities of Tetrads in G-Quadruplexes to Derive a Structure-Activity Relation for a Thrombin-Binding DNA G-Quadruplex Aptamer" chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... #G4 #quadruplex #NMR

13 Apr

Great to see Bruker present our collaboration on facilitating RNA studies by NMR at this year's @enc-conference.org ! More to come soon...😊 #ENC #NMR #RNA #Bruker

Schwalbe Lab reposted

13 Mar

Instruct director Prof. H. Schwalbe participate in the meeting of ITACA.SB, a national programme that supports structural biology in Italy to intensify the links of the Italian community with Instruct-ERIC Find out more here - instruct-eric.org/submit-propo... @schwalbe-lab.bsky.social

onlinelibrary.wiley.comThe Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and EmergenceThis study explores the origins of life by linking prebiotic chemistry, the emergence of information-carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The ....

8 Mar

Our new review in @angewandtechemie.bsky.social is out! It explores the role of chemistry in emergence and complexity at the boundaries with biology, physics, and philosophy. A perspective on chemistry contributing to these interdisciplinary questions. onlinelibrary.wiley.com/doi/10.1002/...

link.springer.comCupriavidus necator, an alternative source for isotopic enrichment of proteins expressed in insect cells for NMR investigations - Journal of Biomolecular NMRIsotopic enrichment of pharmacologically relevant protein targets is crucial for structural studies by nuclear magnetic resonance (NMR) and plays a key role in advancing structure-guided drug discover...

3 Mar

Have a look at our latest publication: Cupriavidus necator as an alternative source for 15N/13C isotopic enrichment of proteins expressed in insect cells for NMR - enabling structural studies of disease-relevant targets. Full text link: link.springer.com/article/10.1...

youtube.comProf. Dr. Harald Schwalbe - Schreibgespräch in der Organischen Chemie und Chemischen BiologieYouTube video by Schreibzentrum Frankfurt am Main

3 Mar

Im Youtube-Kanal des Schreibzentrums findet ihr ein Interview von Harald Schwalbe zum Thema "Schreiben in den MINT-Fächern": www.youtube.com/watch?v=QKFR...

Schwalbe Lab reposted

Katrin Paeschke

@paeschkelab.bsky.social

18 Feb

G4 scientists be ready for the next international meeting on G4 structures - G4thering, which I organize with Robert Hänsel-Hertsch and Harald Schwalbe. At this meeting, G4 related science will be presented and discussed by top scientist. Join us in Frsnkfurt in summer 2027.

Schwalbe Lab reposted

13 Feb

The first talk this morning comes from Harald Schwalbe of @goetheuni.bsky.social, Director of Instruct-ERIC, outlining the future directions of structural biology on the global scale. Find the full paper here - instruct-eric.org/news/the-fut... @schwalbe-lab.bsky.social @itqbnova.bsky.social

academic.oup.comLess missing values—evaluation of proteomics workflows for the quantification of (small) proteinsThis study systematically evaluates methods for improving the identification and quantification of small proteins using bottom-up mass spectrometry, thereb

2 Feb

New paper out in microLife: evaluating proteomics workflows to reduce missing values, with a focus on reliable quantification of small proteins. Practical insights for improving coverage and data quality. academic.oup.com/microlife/ar... #Proteomics #MassSpectrometry #SmallProteins #Microbiology

Schwalbe Lab reposted

Fragment-Screen

@fragment-screen.bsky.social

27 Jan

Fragment-Screen coordinator Harald Schwalbe is presenting on NMR screening and the outcomes of the project at the @eu-openscreen.bsky.social Impulse Winter Training School! Find out more about the meeting and Fragment-Screen here - fragmentscreen.org/winter-train... @schwalbe-lab.bsky.social

Schwalbe Lab reposted

pubs.acs.orgDNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand InteractionsUnderstanding the molecular recognition underlying RNA–ligand complex formation is of key importance to explain the RNA regulatory function of riboswitches and to support the development of low-molecu...

9 Jan

Great to see that the Instruct-ERIC review of the future of integrated structural biology is continuing to be highlighted! Find out more about the paper and read here - instruct-eric.org/news/the-fut... @schwalbe-lab.bsky.social

Schwalbe Lab reposted

anna1312.bsky.social

@anna1312.bsky.social

31 Dec 2025

DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand Interactions | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...