anna1312.bsky.social

anna1312.bsky.social

@anna1312.bsky.social

49 followers139 following33 posts

anna1312.bsky.social reposted

Giovanni Bussi
@bussigio.bsky.social

The timing couldn’t be better: we’ll be using this approach for our #CASP17 RNA solvation submission, in parallel with other strategies we are experimenting with. Looking forward to another blind test!

Bussi Lab@bussilab.org

New #preprint alert! Fast sampling of #RNA–Mg²⁺ binding. @ollyfutur.bsky.social, Elisa Posani and @bussigio.bsky.social present an enhanced-sampling method, extending our top-performing #CASP16 approach, and validate it with #cryoEM. arxiv.org/abs/2607.07186 Summary in thread👇

arxiv.orgEnhanced sampling and cryo-EM data resolve magnesium binding to RNAMagnesium ions are essential for RNA structure but difficult to model due to slow binding kinetics and experimental limitations. We present an enhanced-sampling strategy that accelerates Mg$^{2+}$ inn...

anna1312.bsky.social reposted

Danny IncaRNAto
@incarnatolab.bsky.social

#RNA Framework 2.9.7 is out! Several additions, important fixes and improvements. Please update! Check it out: github.com/dincarnato/R... & see the CHANGELOG (buff.ly/4gtJ67u) for the details!

github.comGitHub - dincarnato/RNAFramework: RNA structure probing and post-transcriptional modifications mapping high-throughput data analysisRNA structure probing and post-transcriptional modifications mapping high-throughput data analysis - dincarnato/RNAFramework

anna1312.bsky.social reposted

Gabrijela Dumbović
@gabrijelad.bsky.social

Our lab is expanding! We are looking for a PhD candidate interested in RNA localization & targeting as part of the newly funded TRR440 smART: specific mRNA targeting. An exciting opportunity to work on RNA biology & innovative approaches in a collaborative environment. For details shorturl.at/RjyhE

anna1312.bsky.social
@anna1312.bsky.social

Structure and sequence characteristics of 5′-stem-loop 1 modulate the escape from nsp1-mediated repression in SARS-CoV-2 variants academic.oup.com/nar/article/...

academic.oup.comStructure and sequence characteristics of 5′-stem-loop 1 modulate the escape from nsp1-mediated repression in SARS-CoV-2 variantsAbstract. Several SARS-CoV-2 variants have evolved with clinical relevance due to their structural and functional impact on viral proteins and genomic RNA

anna1312.bsky.social reposted

Andrii Kozytskyi
@nmrspectroscopy.bsky.social

What’s inside your Coke Zero? 🧪🥤 Ever wondered what a sugar-free drink looks like at the molecular level? This is a 600 MHz ¹H NMR spectrum of Coca-Cola Zero (Ukrainian edition). Even without sugar, the chemistry is dense! Here’s the breakdown: 👇🧵 #nmr #nmrchat #dietcoke

anna1312.bsky.social reposted

VolleyActu
@volleyactu.bsky.social

PERUGIA EN FINALE ! 🎫 Les Block Devils s’imposent en balayant Piacenza en 3 sets et se qualifient pour la finale de la SuperLega 🇮🇹 (27-25, 25-21, 25-15) 📸 LegaVolley

anna1312.bsky.social reposted

Magnetic Resonance News
@nmr900.bsky.social

NMR Facility Manager (Facility Scientist), Pines Magnetic Resonance Center (PMRC) Core Facility, College of Chemistry, the University of California Berkeley, must be authorized to work in U.S. Visa sponsorship is not available aprecruit.berkeley.edu/JPF05294 #NMRjobs #NMRchat #NMR 🧲

aprecruit.berkeley.eduAssociate/Full Specialist (Facility Scientist) - Pines Magnetic Resonance Center (PMRC) Core Facility - College of ChemistryUniversity of California, Berkeley is hiring. Apply now!

anna1312.bsky.social reposted

Schwalbe Lab
@schwalbe-lab.bsky.social

Our new review in @angewandtechemie.bsky.social is out! It explores the role of chemistry in emergence and complexity at the boundaries with biology, physics, and philosophy. A perspective on chemistry contributing to these interdisciplinary questions. onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.comThe Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and EmergenceThis study explores the origins of life by linking prebiotic chemistry, the emergence of information-carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The ....

anna1312.bsky.social reposted

Martin Grininger
@m-grininger.bsky.social

New in Angewandte 🔥: With two engineered changes, we reprogram mammalian fatty acid synthase to make pyrones instead of fatty acids! 🧬 Congrats Felix, Nadja & Caro! We delete the processing part + tweak the KS pocket, even mimicking PKS-like initiation. Paper: doi.org/10.1002/anie...

doi.orgDesign of a Multienzyme Derived from Mouse Fatty Acid Synthase for the Compartmentalized Production of 2‐Pyrone PolyketidesA multienzyme was formed and evaluated by covalently linking 4-coumarate ligase (4CL1) from Piper methysticum to a non-reducing murine fatty acid synthase. 4CL1 acylates the acyl carrier protein (ACP....
anna1312.bsky.social
@anna1312.bsky.social

Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex url: academic.oup.com/nar/article/...

academic.oup.comCrystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplexAbstract. RNA aptamers obtained from in vitro selection experiments provide unique insights into the structural properties and ligand recognition capabilit

anna1312.bsky.social reposted

Juan Pablo Gatti
@gattijuan.bsky.social

Andre Agassi, Rick Leach, John McEnroe, Pete Sampras, Jim Courier, el equipo que llevó a Estados Unidos 🇺🇸 a ganar la Copa Davis en 1992. Posiblemente el mayor Dream Team de la historia del tenis 🎾

anna1312.bsky.social reposted

RCSB Protein Data Bank
@rcsbpdb.bsky.social

Most spiders shut down when temperatures slip below freezing, but Clubiona spiders keep hunting through subzero nights in European orchards, an improbable winter endurance that depends on potent antifreeze proteins flowing through their bodies.

scienceblog.comHow Winter Spiders Keep Their Blood From Turning To IceMost spiders shut down when temperatures slip below freezing, but Clubiona spiders keep hunting through subzero nights in European orchards, an improbable winter endurance that depends on potent antifreeze proteins flowing through their bodies. In work published November 19, 2025 in The FEBS Journal, researchers from Queen’s University in Ontario and collaborators in Czechia analyzed ... Read more
anna1312.bsky.social
@anna1312.bsky.social

Integrative In Silico and In Vitro Screening of Low Molecular Weight Compounds Targeting SARS‐CoV‐2 RNA Elements - Toews - ChemBioChem - Wiley Online Library chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

chemistry-europe.onlinelibrary.wiley.comIntegrative In Silico and In Vitro Screening of Low Molecular Weight Compounds Targeting SARS‐CoV‐2 RNA ElementsA combined virtual and nuclear magnetic resonance (NMR)-based screening approach identifies small molecules that bind conserved SARS-CoV-2 RNA structures. Diverse compound libraries are screened usin....
anna1312.bsky.social
@anna1312.bsky.social

Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular Weight | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

pubs.acs.orgTargeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular WeightWe present the development of low molecular weight inhibitors that target the 5′-terminal RNA stem-loop 1 (SL1) of the SARS-CoV-2 genome. SL1 is crucial for allowing viral protein synthesis in the context of global translational repression in infected cells. We applied compound- and RNA-detected nuclear magnetic resonance spectroscopy (NMR) experiments to guide a fragment-growth strategy based on two primary NMR screening hits from a diverse fragment library poised for follow-up chemistry. These primary hits with molecular weights of around 200 Da were derivatized with the aim of improving the initial solubility, binding affinity, and target specificity. We used NMR to monitor solubility changes, binding affinity, and specific binding to the SL1 binding pocket during the fragment derivatization campaign. Compounds scoring the best in all three categories were further tested for their inhibitory effect on SL1 in a cell-free translation assay, where the best two compounds, A.2 and A.13, showed both significant and selective inhibition. Our results demonstrate that small molecules targeting translation initiation of SARS-CoV-2 can be rapidly obtained using NMR-guided medicinal chemistry, and that the correlation between affinity, selectivity, and in situ function of the derived compounds is still to be explored.

anna1312.bsky.social reposted

Max-Planck-Gesellschaft
@maxplanck.de

Don’t miss it! ✨ The first images from the Vera Rubin observatory will be published on 23 June 2025 at 17:00 CEST. Researchers from the Max Planck Society report on their planned research. www.mpg.de/24900555/ver... #astronomy @vrubinobs.bsky.social @mpi-astro.bsky.social @mpe-garching.bsky.social

mpg.deFirst images of the Vera C. Rubin ObservatoryThe Vera C. Rubin Observatory will publish its first images on 23 June 2025 and will in future explore dark matter and dark energy as well as distant galaxies, supernovae and active centres of galaxie...