Sidrit Uruci (Sid)

Sidrit Uruci (Sid)

@sidrituruci.bsky.social

PhD in @luijsterburglab at @LUMC_Leiden, previously in @Tanejalab at @ErasmusMC. Science lover, DNA enthusiast. European child 🇪🇺🇳🇱🇮🇹🇦🇱🏳️‍🌈

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Sidrit Uruci (Sid)
@sidrituruci.bsky.social

I'm beyond excited and thrilled to share that my first (co)-first-author research paper has been published in Nature 🎉 If I say Transcription-Replication Conflict, do cilia proteins pop in your head? No? Well, understandable, but you'd be wrong! Intrigued? Then read this paper!

Luijsterburglab@luijsterburglab.bsky.social

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

Sidrit Uruci (Sid) reposted

Andrew Blackford
@andrewblackford.bsky.social

Our latest work describing DDIAS as a new component of the TOPBP1-CIP2A pathway in mitosis and its requirement for brain development is now published. Fantastic collaboration with @fenaochs.bsky.social, @profstewartlab.bsky.social, Lars Allan Larsen, @tcr-miller.bsky.social, Zafar Iqbal & others

Cell - a Cell Press journal@cp-cell.bsky.social

Now online! DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development

dlvr.itDDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain developmentDDIAS is identified as a factor that protects single-stranded DNA during mitosis to maintain chromosome stability, and inactivating mutations in DDIAS are identified in a human neurodevelopmental disorder.

Sidrit Uruci (Sid) reposted

Genome Function Lab
@genomefun.bsky.social

Our new paper is finally out! 📢 Great team effort from Sara M, @joanasgrmrtnz.bsky.social and @agalleg.bsky.social with the support from everyone in the lab. Many thanks to our collaborators, @andreichabes.bsky.social , @mmaslon.bsky.social and @lschermelleh.bsky.social

science.orgSlow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speedSlowing RNAPII velocity boosts naive pluripotency, uncovering an unexpected link to cell plasticity.

Sidrit Uruci (Sid) reposted

Kumar Somyajit & Lab
@ksomyajit.bsky.social

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

rdcu.bePAF15–PCNA exhaustion governs the strand-specific control of DNA replicationNature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

Sidrit Uruci (Sid) reposted

Marcel Werner
@marcelwerner.bsky.social

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇

academic.oup.comTranscription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recoveryAbstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat

Sidrit Uruci (Sid) reposted

Sophie van der Horst
@sophievdhorst.bsky.social

Very happy to share that our work on identifying and characterizing factors affecting DNA replication is published by Nature Communications!

Haico van Attikum@haicovanattikum.bsky.social

We present Repli-ID, an approach to identify proteins affecting DNA replication. Lge1 and Rox1 are new regulators of this process. Great work by @sophievdhorst.bsky.social, @lleonie.bsky.social and co-authors in collaboration with @andreichabes.bsky.social. tinyurl.com/mvvcp3xe

tinyurl.comReplication-IDentifier links epigenetic and metabolic pathways to the replication stress response - Nature CommunicationsCells activate various pathways to counter DNA replication stress. Using Replication-IDentifier (Repli-ID), the authors identified 423 genes, including LGE1 and ROX1, linking epigenetic and metabolic ...

Sidrit Uruci (Sid) reposted

bioRxiv Molecular Biology
@biorxiv-molbio.bsky.social

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription https://www.biorxiv.org/content/10.1101/2024.11.20.622938v1

biorxiv.orgRNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription https://www.biorxiv.org/content/10.1101/2024.11.20.622938v1 Independently of the pathways or circuits deregulated in cancer cells, these present altered transcr

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