Genome Function Lab

Genome Function Lab

@genomefun.bsky.social

Working at the interface of DNA replication, transcription, chromatin and nuclear organization. Passionate about genome functionality. María Gómez Lab

73 followers57 following19 posts

Genome Function Lab reposted

Itai Yanai
@itaiyanai.bsky.social

1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists following their curiosity, and this is one huge reason why we must keep funding basic research!

Genome Function Lab reposted

Neuroepigenetics of brain physiology and pathology Lab
@palolab.bsky.social

Happy to share our first review, published by @ejneuroscience.bsky.social : Beyond Bulk: Cell-Type-Resolved Epigenomics as the Path Forward in Alzheimer's Disease Research. What we know and the future of single-cell, cell-type epigenetics for AD. onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.comBeyond Bulk: Cell‐Type‐Resolved Epigenomics as the Path Forward in Alzheimer's Disease ResearchAlzheimer's disease affects multiple brain cell types through distinct epigenetic mechanisms. Although bulk analyses obscure these cell-type-specific changes, cell sorting and single-cell epitranscri...

Genome Function Lab reposted

Enrique Gabandé Rodríguez
@enriquegab.bsky.social

After such as long time of fight, I am thrilled to share our paper in @nataging.nature.com. Thanks so much to my partner in crime @gsotoheredero.bsky.social, all amazing present and former members of Mittelbrunn's lab and to @cbm-csic-uam.bsky.social @csic.es @uam.es www.nature.com/articles/s43...

nature.comCytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling - Nature AgingGabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade ...

Genome Function Lab reposted

David Landeira
@davidlandeira.bsky.social

Want to present your research alongside top global experts in epigenetics? Places are still available for posters and selected short talks at Transcriptional Memory in Health and Disease in Baeza, Spain! Deadline: Sept 20th. Limited to 50 participants. Secure your spot!

Genome Function Lab
@genomefun.bsky.social

Our new paper is finally out! 📢 Great team effort from Sara M, @joanasgrmrtnz.bsky.social and @agalleg.bsky.social with the support from everyone in the lab. Many thanks to our collaborators, @andreichabes.bsky.social , @mmaslon.bsky.social and @lschermelleh.bsky.social

science.orgSlow RNAPII elongation enhances naive pluripotency rewiring while maintaining high replication fork speedSlowing RNAPII velocity boosts naive pluripotency, uncovering an unexpected link to cell plasticity.
Genome Function Lab
@genomefun.bsky.social

Congrats to the whole team!

Carlos Estella@estella-carlos.bsky.social

Some of these mechanisms are also recapitulated by human p53 versions when expressed in Drosophila cells, suggesting broader relevance beyond the fly system. 9/9 Read the paper here: www.nature.com/articles/s41...

nature.comTranscription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis - Cell Death & DiseaseCell Death & Disease - Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis
Genome Function Lab
@genomefun.bsky.social

Superinspiring!-as always

The Francis Crick Institute@crick.ac.uk

“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

Genome Function Lab reposted

Neuroepigenetics of brain physiology and pathology Lab
@palolab.bsky.social

Happy to share our first preprint! Led by @joseruiziglesias.bsky.social — EpiFlow: multidimensional single-cell epigenetic profiling by spectral flow cytometry Many thanks to @cbm-csic-uam.bsky.social, @ageinves.bsky.social and Fundación Ramón Areces for their support www.biorxiv.org/content/10.6...

biorxiv.orgEpiFlow: multidimensional single-cell epigenetic profiling by spectral flow cytometryThe epigenetic landscape of individual cells determines their identity and function, yet current methods for profiling chromatin modifications at single-cell resolution remain low-throughput, costly, or limited in parametric depth. Here we present EpiFlow, a spectral flow cytometry-based platform that enables the simultaneous quantification of 16 epigenetic markers, including histone post-translational modifications, DNA methylation, and hydroxymethylation, at the single-cell level. We demonstrate that EpiFlow is robust across species from yeast to mammals and resolves biologically meaningful epigenetic transitions during the cell cycle, stem cell differentiation, germinal centre B cell maturation, diabetic liver remodelling, and seizure-induced chromatin reprogramming. High-dimensional integration of EpiFlow data enables cell-type classification based solely on epigenetic profiles in liver, brain, blood, and cancer. Furthermore, EpiFlow detects on-target and off-target/indirect effects of epigenetic drugs in a high-throughput-compatible format. Collectively, these results establish EpiFlow as a broadly applicable platform for single-cell epigenetic analysis in basic, pharmaceutical, and translational research. ### Competing Interest Statement The authors have declared no competing interest. Agencia Estatal de Investigación, PID2022-137384OA-I00 (ERDF /EU), RYC2021-031713-I (European Union NextGenerationEU/PRTR), EUR2024-153539, CNS2024-154632 Fundación Ramón Areces, CIVP22A7609
Genome Function Lab
@genomefun.bsky.social

Superb science and great atmosphere! It is a pleasure to attend the R2G2 meetings!

Centro de Biología Molecular Severo Ochoa@cbm-csic-uam.bsky.social

The 2nd Genomic Regulatory Network Annual Meeting, organised by the CBM & funded by @AgEInves, is a great success. Over 3 days, researchers are sharing exciting results, building collaborations, and strengthening connections across institutions. @csic.es @uam.es

Genome Function Lab reposted

ME Torres-Padilla
@metorrespadilla.bsky.social

We go live!!! Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social @replifate.bsky.social @epicrossborders.bsky.social replifate.eu/event/meetin...

replifate.euEvents for February 202606-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

Genome Function Lab reposted

ME Torres-Padilla
@metorrespadilla.bsky.social

Particularly excited to announce "In Formation" 👉Vernissage 17h00 Munich *5th of July* @Muffatwerk 1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin replifate.eu/event/in-for... 😇STAY TUNED 4more info

replifate.euEvents for February 2026We are thrilled to announce In Formation, the first exhibition featuring work from four artist-in-residence projects that bring art into the heart of scientific stem cell and epigenetics research. ...

Genome Function Lab reposted

Centro de Biología Molecular Severo Ochoa
@cbm-csic-uam.bsky.social

Celebramos el #11F con una foto de nuestras compañeras científicas, técnicas, gestoras, etc., en el CBM. 👩‍🔬💫 ¡Por más visibilidad, igualdad y oportunidades para las mujeres en ciencia! #MujeresYCiencia #diadelamujerylaninaenlaciencia #TodasHacemosCiencia

Genome Function Lab reposted

Emilio Lecona
@emlecona.bsky.social

In the Chromatin, cancer and the ubiquitin system lab, we are looking for a candidate to apply for a postdoctoral contract in the Juan de la Cierva call (3 years) www.aei.gob.es/en/announcem...

aei.gob.esAyudas para contratos Juan de la Cierva 2025 | Agencia Estatal de InvestigaciónLas ayudas Juan de la Cierva tienen como finalidad fomentar la incorporación de jóvenes, en posesión del grado de doctor, con objeto de que completen su formación investigadora postdoctoral en centros de I+D españoles.

Genome Function Lab reposted

Centro de Biología Molecular Severo Ochoa
@cbm-csic-uam.bsky.social

📢¡Oferta de trabajo en el CBM! El grupo de César Cobaleda busca postdoc para estudiar cómo se origina la leucemia infantil (B-ALL). 💡 Proyecto “la Caixa” Research Health 2025 🧬 Modelos murinos, epigenética, célula única 📅 Deadline: 5 dic 2025 www.cbm.uam.es/index.php/jo... @cjchcm.bsky.social

cbm.uam.esMolecular Mechanisms of Childhood Leukemia Development - Centro de Biología Molecular Severo OchoaJob Description We are seeking a highly motivated postdoctoral researcher to join our laboratory to study the early steps of development of childhood B-cell Acute Lymphoblastic Leukemia (B-ALL). The p...

Genome Function Lab reposted

Pepi (Josefa) González
@gonzalezlabbcn.bsky.social

Join us! Great line up of speakers on an interesting topic! Thanks to @csic.es Conexion GENOMA for making it possible #TEsky @sesbe-org.bsky.social @sebbm.bsky.social @segenetica.bsky.social @droseu.bsky.social

Sònia Garcia@sphaeromeria.bsky.social

Interested in repetitive DNA? We are organising a free workshop on Oct 2nd at the Botanical Institute of Barcelona! All organisms included - not only plants ;-) Last chance for registration, don’t miss it! bit.ly/repetitiveDN...

Genome Function Lab reposted

ASEICA
@aseica.bsky.social

👉ASEICA reclama➕financiación ante la resolución provisional de la Convocatoria de Proyectos Generación de Conocimiento 2024 @cienciagob.bsky.social ha publicado la resolución provisional de la convocatoria 2024 de Proyectos I+D Gráfica: @jaestebancbm.bsky.social ℹ️ www.aseica.es/aseica-recla...

aseica.esASEICA reclama más financiación ante la resolución provisional de la Convocatoria de Proyectos Generación de Conocimiento 2024El Ministerio de Ciencia, Innovación y Universidades, a través de la Agencia Estatal de Investigación ha publicado la resolución provisional de la convocatoria 2024 de Proyectos I+D. Según aseguran ...

Genome Function Lab reposted

Centro de Biología Molecular Severo Ochoa
@cbm-csic-uam.bsky.social

La semana pasada recibimos en el CBM a 7 estudiantes del programa Científic@s en prácticas. Pasaron cinco días increíbles en los laboratorios de Miguel Manzanares, María Gómez y Natalia Azpiazu. ¡Gracias a l@s investigador@s por su generosidad y a l@s chic@s por su entusiasmo! 🥼

Genome Function Lab reposted

Centro de Biología Molecular Severo Ochoa
@cbm-csic-uam.bsky.social

El Centro de Biología Molecular Severo Ochoa, medio siglo explorando las bases moleculares de la vida #CincuentenarioCBM www.eldiario.es/1_bca1c5?utm... via @efe.com @eldiario.es

eldiario.esEl Centro de Biología Molecular, medio siglo explorando las bases moleculares de la vidaMadrid, 6 jun (EFE).- Los más de 500 científicos y cien grupos de investigación que suma en la actualidad han afianzado el Centro de Biología Molecular Severo Ochoa como uno de los mayores de España y...