Simon Richardson

Simon Richardson

@simonrichardson.bsky.social

Assistant Research Professor and Consultant Haematologist | Researches stem cell biology, epigenetics and drug discovery, specialising in B-ALL | Fellow St Catharine's College, Cambridge

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Simon Richardson reposted

I have two post doctoral positions available in my lab funded by the Wellcome Trust to develop new chemical biology approaches to studying mitochondria. Would suit those with interest in both mitochondria and chemical biology. Advert below-please forward and repost! www.cam.ac.uk/jobs/researc...

cam.ac.ukResearch Associate x 2 (Fixed Term)The Medical Research Council Mitochondrial Biology Unit (MRC MBU), University of Cambridge, wishes to appoint two post-doctoral Research Associates to join the research group of Prof. Mike Murphy at t...

Simon Richardson reposted

Replying to @profmarciniak.bsky.social

Wow! What a day. Thank you so much to Emily Lawson-Todd Our Schools Liaison Officer for organising everything, Kat Steer our comms lead whose TikTok video prompted many applications, fellows Simon Richardson, Nisha Nixon, & Matt Mason for their supervisons and lectures, and our student speakers! ❤️

Simon Richardson reposted

Looking forward to hosting lots of Year 12 students in @stcatharines.bsky.social for our Medical Taster Day Lectures from fellows & talks by current students, mock interview, & Cambridge-style supervisions I can’t wait !

St Catharine's College@stcatharines.bsky.social

If you know Year 12 students thinking about studying medicine, let them know about our free taster day hosted by our students, staff & Fellows, incl. Stefan Marciniak (2011) as Director of Studies in Clinical Medicine. Sign up by 15 June: caths.cam.ac.uk/med 📸 Melanin Medics @cam.ac.uk

Simon Richardson reposted

Simon Richardson reposted

We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience! shorturl.at/hZ6mG

Simon Richardson reposted

2025 is drawing to a close and what a year it’s been! 🌟 From growing our community to advancing research and transforming clinical practice, it’s been a year full of progress. Here are some of our 2025 highlights. 👇 Season's greetings to all our members, partners and supporters!

Simon Richardson reposted

Brian Huntly and I are looking to recruit a postdoc to investigate a promising novel therapeutic target in B-ALL @scicambridge.bsky.social. This new CRUK-funded project will involve collaboration with Prof Sir Steve Jackson's group @cruk-ci.bsky.social and the CRUK Functional Genomics centre.

cam.ac.ukResearch Associate (Huntly Lab - Fixed Term)We are seeking a postdoctoral Research Associate to work on an exciting new multi-disciplinary project studying B-cell acute lymphoblastic leukaemia (B-ALL). The project is a collaboration between Dr

Brian Huntly and I are looking to recruit a postdoc to investigate a promising novel therapeutic target in B-ALL @scicambridge.bsky.social. This new CRUK-funded project will involve collaboration with Prof Sir Steve Jackson's group @cruk-ci.bsky.social and the CRUK Functional Genomics centre.

cam.ac.ukResearch Associate (Huntly Lab - Fixed Term)We are seeking a postdoctoral Research Associate to work on an exciting new multi-disciplinary project studying B-cell acute lymphoblastic leukaemia (B-ALL). The project is a collaboration between Dr

Simon Richardson reposted

A decade of bold ideas, brilliant minds & real impact. 💡 Our John Goldman Fellowships are driving progress in leukaemia research, from identifying new drug targets to repurposing existing medicines. Read more: www.leukaemiauk.org.uk/stories/a-de...

leukaemiauk.org.ukA decade of progress and impact - Leukaemia UKThis October marks ten years since Leukaemia UK launched its John Goldman Fellowship (JGF) programme. In this blog, and the next, we’ll explore its impact and successes.

Thanks to @leukaemiauk.bsky.social for the opportunity to contribute to this amazing session. So important to link patient experiences with our science and translational research

Leukaemia UK@leukaemiauk.bsky.social

An incredibly inspiring and thought-provoking Q&A session with some of our John Goldman Fellows and Leukaemia UK Community Champions. ✨ @simonrichardson.bsky.social @scicambridge.bsky.social @manchester.ac.uk @uom-dcs.bsky.social

Simon Richardson reposted

Replying to @stcatharines.bsky.social

💙 Between now & the UCAS application deadline on 15 Oct, it’s worth checking if you're eligible for the Finlay Family Bursary, which covers all tuition fees & a living allowance for a St Catharine’s student from Scotland for all 3 or 4 years of an undergraduate degree: shorturl.at/K0RuE 3/3

shorturl.atThe Finlay Family Bursary for Scottish undergraduatesWe are proud to offer this bursary to encourage Scottish students to apply for, and take up, the offer of an undergraduate place at St Catharine’s – an opportunity which would normally involve greater financial cost than attending a Scottish university.

Simon Richardson reposted

I’m looking for a Postdoc to join my new lab @pdncambridge.bsky.social on an MRC-funded project and explore maternal inter-organ communication with a focus on the mammary gland, using a novel mouse model. 📍 Tenure: 3 years ⏳ Deadline: 15 August 2025 Please RT 🙏 👉 www.jobs.cam.ac.uk/job/51984/

jobs.cam.ac.ukResearch Associate (Fixed Term) - Job Opportunities - University of CambridgeResearch Associate (Fixed Term) in the Department of Physiology, Development and Neuroscience at the University of Cambridge.

Really exciting to co-organise the 20 year graduation reunion for Oxford medical school last night. Wonderful to reunite with old friends and hear retired DoS Tim Lancaster speak powerfully about how caring is at the heart of good medicine 💊❤️

10/12 Excitingly, the CREBBP inhibitor Inobrodib has already been tested in combination with Venetoclax in AML, confirming safety. We therefore think this could be a novel, safe, oral approach that could complement current chemo- and immunotherapies, improving outcomes and reducing toxicity.

7/12 Interestingly, these changes can also be seen in patients – TARGET RNAseq data showed that low expression of CREBBP strongly correlates with dysregulation of ether-linked lipid pathways and up-regulation of redox scavengers.

8/12 Only 20% of patient have a CREBBP mutation at relapse, yet this is a very strong mechanism. We therefore tested whether pharmacological inhibitors of CREBBP can sensitise B-ALL to Venetoclax, irrespective of genetic subtype.

6/12 Transcriptional, proteomic and lipidomic analysis of our cell line models showed up-regulation of redox-protective pathways, alongside changes in lipids, including low levels of peroxisomal/ER ether-linked lipids, and high levels of ferroptosis-susceptible membrane PUFAs.

3/12 We used CIRPSR to genetically-engineer B-ALL cell lines that only differed in the presence or absence of various CREBBP mutations. The result: CREBBP loss reduced gene transcription, and phenotypically resulted in higher levels of metabolism and a paradoxical *slowing* of cell cycle.

2/12 CREBBP mutations are associated with high-risk and chemoresistance in B-ALL, and are enriched at relapse. We wanted to understand what CREBBP is doing in B-ALL and identify novel drugs to treat these high-risk patients.

Simon Richardson reposted

We were delighted to welcome Lord Vallance, Minister of State for Science, last week. Hala Al-Haboubi (a 3rd-year medical student at Catz) said, "Lord Vallance shared inspirational, forward-looking insights about the future of scientific research. It was a real privilege to hear from him!" 1/3