Manav Pathania

Manav Pathania

@manavpathania.bsky.social

Unravelling the biology of brain tumours like #DMG #DIPG #glioma in children and young people. CRUK Career Establishment Award recipient 🏳️‍🌈🇮🇳🇭🇰🇲🇾🇸🇬🇺🇲🇬🇧 https://www.pathanialab.com

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Manav Pathania
@manavpathania.bsky.social

Hi Bluesky! I am a PI in the Dept of Oncology at the University of Cambridge, UK. Our lab develops mouse models of different types of brain tumours and uses these to explore targeted treatments, TME interactions, and the role of heterogeneity in resistance. doi.org/10.1158/2159...

doi.orgA Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic VulnerabilitiesModels of pediatric high-grade glioma reveal genotype–phenotype associations, differences in cell type composition, and sensitivity to targeted and combination therapy approaches, making preclinical e...
Manav Pathania
@manavpathania.bsky.social

We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience! shorturl.at/hZ6mG

Manav Pathania reposted

Robin Bisson
@robinbisson.bsky.social

The reforms to UKRI under Ian Chapman are only just starting, but there are already worries about what they mean for the bread and butter, applicant-led funding calls at research councils While UKRI insists comparisons with previous years are impossible, figures from December suggest...

Manav Pathania
@manavpathania.bsky.social

The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned! shorturl.at/thpyK

shorturl.atLudwig Oxford welcomes Dr Manav PathaniaLudwig Oxford is delighted to welcome Dr Manav Pathania as an Assistant Member of the Ludwig Institute for Cancer Research, Oxford Branch.

Manav Pathania reposted

eric lai
@lucksmith.bsky.social

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase

tinyurl.comFlyBase secures funding for year, but future still uncertainThe FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.

Manav Pathania reposted

Jeremy Berg
@jeremymberg.bsky.social

Yes, it was carefully hidden in the New England Journal of Medicine. Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... ) 1/2

Elizabeth Jacobs, PhD@elizabethjacobs.bsky.social

Trump on RFK Jr., the CDC, and vaccines (a translation). He seems to be saying that he was shown data about COVID19 vaccines being safe and effective, but that the pharma companies didn’t show those amazing data to anyone else, like RFK Jr. He thinks this is why there is a “mess” at CDC.

Manav Pathania reposted

Dr. Rajesh Khanna of the KhannaLabUF
@khannalabuf.bsky.social

WOW!!!!!😱😮 High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...

cell.comHigh-speed mapping of whole-mouse peripheral nerves at subcellular resolutionA high-speed pipeline enables whole-mouse imaging and mesoscopic analysis of peripheral nerves using transgenic, immunostaining, and viral labeling, providing an effective means to map body-wide struc...

Manav Pathania reposted

Nature Portfolio
@natureportfolio.nature.com

A study in Nature Medicine shows the mechanisms driving amyloid-β clearance in both passively and actively Aβ immunized patients with Alzheimer’s disease. #alzsky 🧪

go.nature.comMicroglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature MedicineSpatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.

Manav Pathania reposted

Agingdoc⭐David Barzilai🔔MD PhD, MS, MBA, DipABLM
@agingdoc.bsky.social

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length 👉 These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer. www.nature.com/articles/s41...

nature.comModification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length - Nature CommunicationsMice models often fail to reflect human telomere biology. Here, the authors engineer a mouse strain with a humanized mTert gene, restoring telomere length regulation to a human-like pattern. This mode...

Manav Pathania reposted

Deborah Blum
@deborahb.bsky.social

From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.

Manav Pathania reposted

Ed Chuong
@edchuong.bsky.social

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

cell.comRegulation of human interferon signaling by transposon exonizationTransposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

Manav Pathania reposted

Anna Obenauf
@obenaufa.bsky.social

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

nature.comCancer cells impair monocyte-mediated T cell stimulation to evade immunity - NatureInflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
Anna Obenauf@obenaufa.bsky.social

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Manav Pathania
@manavpathania.bsky.social

Happy International Day of LGBQTIA+ People in STEM! Proud to advocate for the enriching benefits of diversity, of experiences and viewpoints, IRL and on this platform.

Pride in STEM@prideinstem.bsky.social

November 18 is the International Day of LGBQTIA+ People in STEM! Today more than ever we want to stress the importance of communities, building connections, and raising each other up. Let's keep leaving our mark for the betterment of us all! 🏳️‍⚧️🏳️‍🌈 #QueerinSTEM prideinstem.org/lgbtstemday/

Manav Pathania
@manavpathania.bsky.social

I reserved my first Bluesky post to mark another enjoyable and successful collaboration with the Jabado and Kleinman labs! Congrats to @selinjessa.bsky.social, Bhavyaa and Antonella on this cool paper! doi.org/10.1158/0008...

doi.orgFOXR2 targets LHX6+/DLX+ neural lineages to drive CNS neuroblastomaAbstract. Central nervous system neuroblastoma with FOXR2 activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and...

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