Spang Lab

Spang Lab

@spanglab.bsky.social

We are scientists interested in understanding the basics of how a cell, the building block of our body, works. @biozentrum @UniBasel_en #cellbio #Biozentrum #RNA #organelles #membranes #aging #stress #proteostasis #signaling

470 followers108 following17 posts

Spang Lab
@spanglab.bsky.social

check out our newest contribution to the understanding on how to efficiently recycle! great work by Jachen Solinger!

Journal of Cell Biology@jcb.org

Solinger et al. @spanglab.bsky.social @biozentrum.unibas.ch show that Arf1-GTP/GDP cycles drive adaptor complex–cargo interaction and release cycles, which are essential for cargo inclusion into Rab11 recycling vesicles at FERARI-mediated kiss-and-run sites. rupress.org/jcb/article/... #Endosomes

Spang Lab
@spanglab.bsky.social

We miss you!

Journal of Cell Biology@jcb.org

The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with ideas reshaped how we think about cellular organization. #InMemoriam from @adamgrieve.bsky.social and colleagues: rupress.org/jcb/article/...

Spang Lab
@spanglab.bsky.social

Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...

biorxiv.orgCa2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sitesLysosomes are essential in maintaining cellular health. Endocytic lysosome reformation (ELR) regenerates functional lysosomes following degradation of endocytic cargo, yet the mechanisms driving this process remain largely unknown. Here, we define the molecular machinery underlying ELR. We find that unlike autophagic lysosome reformation (ALR), ELR proceeds independently of mTOR and dynamin 2, but requires the mitochondrial fission GTPase DRP1. DRP1 mediates scission of endolysosomal tubules at contact sites with the endoplasmic reticulum (ER) and mitochondria. Disruption of DRP1 function or ER endolysosome contact results in elongated tubules, indicating defective lysosome reformation. Moreover, mitochondrial activity is essential for tubule initiation, and Ca2+ transfer from endolysosomes to mitochondria is crucial for ELR onset. Our findings reveal a dual role for mitochondria in ELR: first in ELR initiation and second in DRP1-dependent tubule fission at ER-mitochondria-endolysosome tripartite contact sites, uncovering the previously unappreciated role of mitochondria in endolysosome remodeling and fission. ### Competing Interest Statement The authors have declared no competing interest. Swiss National Science Foundation, 320030-231859, 310030-197779 University of Basel, https://ror.org/02s6k3f65

Spang Lab reposted

Fran Bottanelli
@franbottanelli.bsky.social

Happy that we could contribute to this exciting paper from the @spanglab.bsky.social!

Ishier Raote@ishier.bsky.social

Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles. ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs www.biorxiv.org/content/10.6...

Spang Lab
@spanglab.bsky.social

A little stress is good for you in #health #ageing ! #Diet is important! Take a look at our article with Emmanouil Kyriakakis as 1st author! @unibas.ch @natcomms.nature.com @snsf.ch #Longevity #healthspan rdcu.be/eI1vZ

rdcu.beBacterial RNA promotes proteostasis through inter-tissue communication in C. elegansNature Communications - Kyriakakis et al. show that bacterial RNA can improve C. elegans healthspan and reduce toxic protein aggregation in muscles. This depends on inter-tissue communication and...

Spang Lab reposted

Biozentrum, University of Basel
@biozentrum.unibas.ch

Congratulations to Anne Spang @spanglab.bsky.social for being elected as a new #AAASFellow by @aaas.org ! The world’s largest scientific society recognizes her outstanding contributions to the field of cell #biology and #biochemistry. @unibas.ch www.biozentrum.unibas.ch/news/detail/...

biozentrum.unibas.chAnne Spang awarded distinction of AAAS FellowThe AAAS has elected Prof. Anne Spang at the Biozentrum, University of Basel, as a Fellow. With this honor, the world’s largest scientific society recognizes her outstanding contributions to the field...
Spang Lab
@spanglab.bsky.social

We got the cover!!! Check out our new story in EMBO J. #endosomes #c.elegans #membranes #GTPases

The EMBO Journal@embojournal.org

In issue 6: Commentary: organoids for decoding host-microbe interactions Importance of mitochondrial DNA elimination during spermatogenesis How kinesin KIF12 promotes steatohepatitis Cancer cell adaptation strategies to aneuploidy Cover: Daniel Ott, Anne Spang et al www.embopress.org/toc/14602075...

Spang Lab
@spanglab.bsky.social

Interested how events are coordinated during #endosome maturation? Check out our latest paper! Congrats Daniel, Samit and Jachen! www.embopress.org/doi/full/10....

embopress.orgCoordination between ESCRT function and Rab conversion during endosome maturation | The EMBO JournalimageimageEarly endosome maturation requires Rab conversion and ESCRT function; however, how these processes are coordinated remains largely elusive. This study proposes that Rab conversion in both C....
Spang Lab
@spanglab.bsky.social

I feel humble and honored to receive the Lelio Orci Award 2024. I want to thank my amazing co-workers and trainees who are with me on the pursuit of the understanding how intracellular communication is achieved.

Biozentrum, University of Basel@biozentrum.unibas.ch

Congratulations to Anne Spang for receiving the renowned Lelio Orci Award. The award honors her pioneering work in intracellular organization and her research achievements in Cell Biology. @unibas.ch www.biozentrum.unibas.ch/news/detail/...

biozentrum.unibas.chAnne Spang receives Lelio Orci Award 2024Prof. Anne Spang at the Biozentrum, University of Basel receives the Lelio Orci Award 2024 for her pioneering work in intracellular organization. The award honors outstanding scientists for their rese...

You are up to date.