Ishier Raote

We found that cells survive a proteostasis defect, but not the lipid imbalance it causes. Rer1 & the Dsc complex triage orphan membrane proteins at the Golgi. Lose both & DAG-rich multilamellar compartments (DMCs) form. Drain DAG & cellular architecture recovers. www.biorxiv.org/content/10.6...

Our recent work on #Cellularization of the #ichthyosporean S. arctica is finally out in its final form @lsajournal.org www.life-science-alliance.org/content/10/1... Congrats to @margaridaaraujo.bsky.social @hiralshah.bsky.social @gautamdey.bsky.social & the rest of the team

link.springer.com/article/10.1...

In 2002, success rate at the ERC starting grant was 14%. This already felt too low to both panel and applicants, but was constrained by government funding. Well, 5 years later, it is now projected to be 5%. This is not sustainable.

Cripes. The ERC StG success rate is expected at around 5% this year: 373 grants for 7710 applications. Research strategies across the EU are shaped around securing ERC grants. But with such low odds, aligning national or institutional priorities with ERC objectives becomes a deeply flawed strategy.

Registration is open for the 2027 @embo.org Workshop on Cell Polarity and Membrane Dynamics, co-organized with @alexludwig.bsky.social and @dianapinheiro.bsky.social. Join us in May 2027 in Sant Feliu de Guíxols, near Barcelona! meetings.embo.org/event/27-cel... #EMBOCellPolarity

Please see our latest paper on TANGO1. This work was instigated by the great, late David Stephens and we're so happy his legacy continues. Congrats to first author @lizzielawrence.bsky.social and co-authors @hammofish.bsky.social, Esther, Judith, and Lorna! journals.biologists.com/jcs/article/...

Research Associate and Postdoc Opportunities! I am happy to announce that I will establish a new laboratory at Hong Kong University of Science and Technology (HKUST) to start a major research program supported by a multi-year FTRSS grant.

This is a good week! On Monday, my PhD co-supervisor @deisseroth.bsky.social was awarded the @nobelprize.org for his work on optogenetics. Yesterday, I submitted my primary postdoc work on photopharmacology, a complementary method that uses light for the precise spatial and temporal release of drugs

How cells adapt their membranes to prolonged stress is poorly understood. Williams, Klose, Ernst, and Carvalho @dunnschool.bsky.social show that chronic hyperosmotic stress triggers #LipidDroplet accumulation and a shift toward phosphatidylcholine in budding #yeast. rupress.org/jcb/article/...

How do long-lived multipotent stem cells cope with mechanical stress in vivo? We found that neural crest cells are protected from mechanical stress during migration in confined tissue environment. www.nature.com/articles/s41...

Responses to endoplasmic reticulum stress at a glance journals.biologists.com/jcs/article-...

Why does filling out a CV on an online portal have to be so tedious? In the end, people only look at the list of publications anyway. Surely there’s a more efficient way to do this! A little less form-filling would be very welcome.

Nice preprint from Aki Nakano and Manuel Muñiz! Using SCLIM, they show COPI recycling in yeast occurs during transient cis-Golgi-ERES contacts. Retrograde transport and ER export are coupled - promoting cis Golgi detachment. www.biorxiv.org/content/10.6...

Happy to share our review on ROS evolution, regeneration and therapeutics, published in Cell Mol Life Sciences. Led by our former PhD student Aurore Vullien, co-supervised with @rottingerlab.bsky.social in collab. with @christinerampon.bsky.social and J. John & E. Amaya. doi.org/10.1007/s000...

Membrane Trafficking Seminar series returns this week with two exciting talks exploring GTPase regulation and the making of lysosomes! Join @felixmendu.bsky.social @franbottanelli.bsky.social and me for an afternoon of fun cell biology. For more details: felixcampelo.wixsite.com/membranetraf...

Happy to see our latest work published in @jcb.org. Led by an excellent PhD student, Abir Elfarkouchi, and in collaboration with @francoizochsenbein.bsky.social and co-first author Arthur Vitard, we investigated the structural mechanism of CM1 domain autoinhibition rupress.org/jcb/article/...

Abir Elfarkouchi, Arthur Vitard, @francoizochsenbein.bsky.social, @pconduit.bsky.social et al. reveal the first structural model for γ-TuRC CM1 domain autoinhibition, which prevents ectopic binding and activation of #microtubule-nucleating γ-tubulin ring complexes. rupress.org/jcb/article/...

UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....

Curious how lipid droplets support innate immunity in our cells? Check out our lipidomics by Bosch et al @cp-cellreports.bsky.social! Critical role of LD phospholipids and lipases in supplying defensive w6 arachidonic acid for inflammation and bacterial phagocytosis. www.cell.com/cell-reports...

#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas

In @pcusachs.bsky.social’s lab at @ibecbarcelona.eu we have a fully founded open PhD position! It’s a very nice working environment & can promise cool mechanobiology🔬🧫 Here all the info ibecbarcelona.eu/predoctoral-...

AAAAAAAAAAAAAAAAAAAAHHHHHHHHHH

#membranetrafficking seminars are back for the fall session! This Thursday two exciting talks from Roger Pons Lanau from @felixmendu.bsky.social lab and @veijosalo.bsky.social #ER #lipiddroplets and lots of wonderful imaging! From single molecules to cryo EM! Please repost

Really excited to talk about our recent work next week Thursday in Membrane Trafficking Virtual Community Seminar Series!

Stretching the secretory pathway: mechanical control of #Golgi export. Angelika Hausser @angelikahausser.bsky.social highlights new work by Bhaskar Naidu, Vera Lillo, Manneville, Miserey, @felixmendu.bsky.social et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...

📢 Institut Jacques Monod Seminar 📅 September 18th 📍Institut Jacques Monod Next week, Prof. Omaya Dudin ( @dudinlab.bsky.social ) will present an Institut Jacques Monod seminar on the theme "Exploring multicellular developmental programs at the root of animals and beyond" ➡️ buff.ly/mY66omK

If AI can solve the Navier–Stokes equations and predict protein structures, do you really expect me to believe it can’t find the accursed bicycles or traffic lights?

LLMs starting to solve long-standing problems! ChatGPT: P = NP Me: I think you're wrong ChatGPT: That's correct. I'm sorry. Thanks for pointing it out. P ≠ NP QED.

Very happy to see our Nature Reviews Genetics article on programmed DNA elimination across eukaryotes out! A fantastic collective effort with an amazing group of colleagues, born from inspiring discussions at the Fondation des Treilles. rdcu.be/tmvKgsPZNhBa @laurarossevo.bsky.social

Do not miss this fantastic symposium #lipidtime

I'm willing - grudgingly - to accept that Lifeact is not a valid pangram in today's Spelling Bee, but what's wrong with felicitate?!

The ULK1 complex triggers autophagy on membranes, but with no typical membrane binding domains, how does it get there? See the answer in a brilliant collective effort out now in Science Advances: www.science.org/doi/10.1126/....

Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22

Many thanks @jcb.org and @angelikahausser.bsky.social for highlighting our recent findings on how the Golgi responds to mechanical forces! As nicely pinpointed out, many (I think exciting and relevant) questions remain open, so I'm looking forward to seeing how this evolves in the next few years!

I never get bored of watching my favorite lipid, PI(4,5)P2 - especially in real time! In this case imaged with a HaloTag-biosensor and 50 pM JF646.

Collagen remodeling supports Hydra vulgaris head regeneration and stem cell invasion Read this Research Article from our special issue #DevSIextracellular by Ben Cox, Celina E. Juliano and colleagues. journals.biologists.com/dev/article/...

Brandnew preprint from @marius-lemberg.bsky.social @bccologne.bsky.social and my lab ! Great to be Part of this collaboration!

Happy 50th anniversary, Clathrin! onlinelibrary.wiley.com/doi/full/10.... @effc.bsky.social

Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).

For the last year, aECM Club seminars have brought together researchers working on apical ECM in diverse species and tissues - yeast cell wall, C. elegans cuticle, Drosophila lens, mammalian inner ear and pancreatic lumen, and many others. Sign up for 2026-27: forms.gle/DDJUxGLkcSRb...

Cellularization as a mechanism to build cells. #CellBio #DevBio Supported by @girishkalephd.bsky.social, Anne Ruess highlights a #preprint of @margaridaaraujo.bsky.social et al. @hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social #preLight⬇️ prelights.biologists.com/highlights/m...

exoendo.org/en/offre-dem...

What does an ovary actually look like as it ages—one oocyte at a time? We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan. And the ovary turned out to be much more organized than we expected. 🧵 1/5 www.nature.com/articles/s43...

What an amazing, visceral experience it is, to watch the sun quickly and inexorably eaten up by the moon.