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Srijit Seal ๐Ÿ‡บ๐Ÿ‡ธ๐Ÿ‡ฌ๐Ÿ‡ง๐Ÿ‡ฉ๐Ÿ‡ช๐Ÿ‡ฏ๐Ÿ‡ต๐Ÿ‡ฎ๐Ÿ‡ณ

@srijitseal.com

Senior Chemรธinformatician at Merck | Postdoc@Broad Institute of MIT and Harvard, Cambridge(MA) | PhD@University of Cambridge(UK) | AI, Image Analysis, bioML, -omics data, and Cell Painting for drug discovery. srijitseal.com/tools

3.5K followers4.3K following189 posts

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@srijitseal.com

Thank you for highlighting our work! Use DILIpred to figure out if your compounds have any DILI risk, with mechanistic features :D DILIPred was bulit with over 15k compounds and covers a large chemcial space!

macinchem.bsky.social@macinchem.bsky.social

Drug-induced liver injury (DILI) is a significant concern in drug discovery, in particular because it might only be observed late in large clinical studies. Dilipred is an interesting in-silico tool using variety of approaches to identify potential for hepatotoxicity. macinchem.org/2025/03/02/u...

macinchem.orgUsing DILIpred โ€“ Macs in Chemistry
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@srijitseal.com

By combining information bottleneck methods with context graphs, weโ€™re able to extract minimal yet sufficient representations of molecules that lead to better predictions and generalization in downstream tasks like molecular property prediction and zero-shot molecule-morphology matching.

lnkd.inLinkedInThis link will take you to a page thatโ€™s not on LinkedIn

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God
@thegodshow.com

Thou shalt not promise lower grocery prices and then deliver war against Panama, Canada, and Greenland.

Srijit Seal ๐Ÿ‡บ๐Ÿ‡ธ๐Ÿ‡ฌ๐Ÿ‡ง๐Ÿ‡ฉ๐Ÿ‡ช๐Ÿ‡ฏ๐Ÿ‡ต๐Ÿ‡ฎ๐Ÿ‡ณ reposted

Kresten Lindorff-Larsen
@lindorfflarsen.bsky.social

โ€œYour scientists were so preoccupied with whether or not they could, they didn't stop to think if they shouldโ€

Nature Portfolio@natureportfolio.nature.com

Two machine learning algorithms can determine whether a whisky is of American or Scotch origin and identify its strongest aromas, according to research in Communications Chemistry. https://go.nature.com/3DpO8nl ๐Ÿงช

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Pranav Rajpurkar PhD
@rajpurkar.bsky.social

I don't think it's widely clear to the #RadiologyAI community just how poorly GPT-4V compares with the top report generation models on chest X-rays, like MedVersa or MAIRA-2. It's clear we need a way to track progress.

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Brendan
@chemscrapes.bsky.social

Atomic orbitals at the beach #chemsky ๐Ÿงช

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Andreas Bender
@andreasbender.bsky.social

The next Cambridge Cheminformatics Newsletter, December 2024 Edition is out! Containing upcoming related events, news jobs and resources For details please see: www.drugdiscovery.net/2024/12/22/c... Have a good Christmas/Holiday period everyone! All the best and see you in 2025, Andreas

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Jess Ewald
@ewaldlab.org

๐ŸŽ‰ I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) ๐ŸŽ‰ We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods. I am beginning the search for two postdocs now - stay tuned for more details! ewaldlab.org

ewaldlab.orgEwald Lab@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.

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Beth Cimini ๐Ÿ”ฌ๐Ÿ’ป๐Ÿ“Š
@bethcimini.bsky.social

New Year, new job? Delighted to announce two early-career-level (post-BA/BS or MA) positions in my lab, and an open call for computational postdocs at the Broad! First, an image analysis associate - work on high content screens for all kinds of cells and dimensionalities! See more at link (1/4)

docs.google.comImage analysis associate job descriptionImage Analysis Associate Broad Institute of MIT and Harvard, Cambridge, MA Impact the discovery of new disease therapies in the Cimini laboratory at the Imaging Platform Join our vibrant, world-clas...

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Anne Carpenter
@drannecarpenter.bsky.social

We've a postdoc opening for our lab at the Broad: Cambridge MA! Must have experience in toxicology + data science Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models! broad.io/mlcbpostdoc

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@srijitseal.com

Postdoctoral Opportunity!

Jess Ewald@ewaldlab.org

๐ŸŽ‰ I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) ๐ŸŽ‰ We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods. I am beginning the search for two postdocs now - stay tuned for more details! ewaldlab.org

ewaldlab.orgEwald Lab@ EMBL-EBI. We identify and characterize chemical hazards to both humans and ecosystems with cell profiling data, machine learning, and integrative data analysis.

Srijit Seal ๐Ÿ‡บ๐Ÿ‡ธ๐Ÿ‡ฌ๐Ÿ‡ง๐Ÿ‡ฉ๐Ÿ‡ช๐Ÿ‡ฏ๐Ÿ‡ต๐Ÿ‡ฎ๐Ÿ‡ณ reposted

Chaitanya K. Joshi
@chaitjo.bsky.social

My (I think funny) take on AlphaFold3 and equivariance: There are many versions of AF3 which may be better at different tasks โ€” The one they publicly released is as diametrically opposite in terms of architecture (no equivariance, no frames, generative) to RosettaFold-AllAtom.

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@srijitseal.com

Replying to @srijitseal.com

rdcu.be/d2vHH

rdcu.beCell Painting: a decade of discovery and innovation in cellular imagingNature Methods - This Review synthesizes the literature from over 10 years of Cell Painting for image-based profiling and highlights how advances in this technology enable new biological discovery...
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@srijitseal.com

The JUMP-Cell Painting findings with genetic perturbations are now released!

Anne Carpenter@drannecarpenter.bsky.social

Now on biorxiv! The JUMP-Cell Painting Consortiumโ€™s paper: โ€œMorphological map of under- and over-expression of genes in human cellsโ€ This is the genetic perturbation portion of the JUMPโ€™s dataset; our chemical perturbation paper will come in a few months www.biorxiv.org/content/10.1...

biorxiv.orgMorphological map of under- and over-expression of genes in human cellsCell Painting images offer valuable insights into the state of a cell and enable many biological applications, but publicly available arrayed datasets only include hundreds of genes perturbed. The JUM...

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Bluesky
@bsky.app

Scientists, academics, researchers: Weโ€™re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! ๐Ÿงช

Altmetric@altmetric.com

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research. A Place of Joy.

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Fritz Roth
@fritzroth.bsky.social

Calling all systems and computational biologists in search of a faculty position: We have Assistant and Associate Professor positions! ๐Ÿš€ Pittsburgh is beautiful, and we are doing amazing science here. cfopitt.taleo.net/careersectio... cfopitt.taleo.net/careersectio... Please apply by Dec 2!

cfopitt.taleo.netFaculty.Professor.Assistant - Full-TimeClick the link provided to see the complete job description.

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BrooklynDad_Defiant!
@mmpadellan.bsky.social

You don't need to be a rocket scientist or a brain surgeon to see why Bluesky is the place to be. But welcome scientists, thank you for joining us! ๐Ÿ‘‹

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Woody Sherman
@woody-sherman.bsky.social

Just announced: 2025 Computer-Aided Drug Design (CADD) GRC program The topic: "Exploring the Synergy of Machine Learning and Physics-Based Computational Chemistry to Accelerate Drug Discovery" It is shaping up to be a seminal conference. Hope to see you there! www.grc.org/computer-aid...

grc.org2025 Computer Aided Drug Design Conference GRCThe 2025 Gordon Research Conference on Computer Aided Drug Design will be held in Portland, Maine. Apply today to reserve your spot.