Chris Wells

Chris Wells

@stemcellsystems.bsky.social

Curiosity fuelled biomedical researcher, I build computational and stem cell models of human innate immune cells | Professor of Stem Cell Systems at the University of Melbourne, Australia.

582 followers240 following106 posts

Chris Wells
@stemcellsystems.bsky.social

Hamid speaking to new tool: SemanticST to analyse spatial transcriptomics and preprinted @arxiv.bsky.social arxiv.org/abs/2506.11491

arxiv.orgSemanticST: Spatially Informed Semantic Graph Learning for Clustering, Integration, and Scalable Analysis of Spatial TranscriptomicsSpatial transcriptomics (ST) technologies enable gene expression profiling with spatial resolution, offering unprecedented insights into tissue organization and disease heterogeneity. However, current...
Chris Wells
@stemcellsystems.bsky.social

Drew Neavin #ASSCR2025 using 'village in a dish' models to study the genetics underpinning cardiotoxicity Unpublisjed data so reference is to the village in a dish model. pmc.ncbi.nlm.nih.gov/articles/PMC...

pmc.ncbi.nlm.nih.govA village in a dish model system for population-scale hiPSC studiesThe mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions. Human induced pluripotent stem cells are uniquely suited to ...
Chris Wells
@stemcellsystems.bsky.social

Kathrine Zyner presents 'ReFate' #ASSCR2025 which combines gene regulatory networks with compounds that impact on these regulatory pathways to improve cell reprogramming @biorxivpreprint.bsky.social doi.org/10.1101/2025...

doi.orgRefate identifies chemical compounds to target trans-regulatory networks for cellular conversionIdentifying chemical compounds that target trans-regulatory networks (TRNs) underlying molecular programs of cells for directed cellular conversion (i.e. differentiation, reprogramming, transdifferent...

Chris Wells reposted

Melbourne Bioinformatics
@melbioinf.bsky.social

How would you like to apply your passion for #bioinformatics to a real-world research problem? We co-supervise PhD students in a wide variety of research groups across the University of Melbourne and the Melbourne Biomedical precinct. If you're interested in doing a PhD with us, get in touch!

mdhs.unimelb.edu.auPhD Research ProjectsLearn how to use the tools you need to apply bioinformatics techniques in your own research.

Chris Wells reposted

Stem Cell Reports
@stemcellreports.bsky.social

Meet our Early Career Editor at #ASSCR2025! Pengyi Yang is attending the Australasian Society for Stem Cell Research (ASSCR) Conference in Gold Coast, Australia, 10-12 November 2025. Connect with Dr. Yang to discuss whether your research is a fit for publishing in Stem Cell Reports!

Chris Wells
@stemcellsystems.bsky.social

Ritika Saxena @ritikasxn.bsky.social speaking about hPSC-derived blood. pmc.ncbi.nlm.nih.gov/articles/PMC... @asscr.bsky.social #ASSCR2025

pmc.ncbi.nlm.nih.govLong-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cellsHematopoietic stem cells (HSCs) derived from human induced pluripotent stem cells (iPS cells) have important biomedical applications. We identified differentiation conditions that generate HSCs defined by robust long-term multilineage engraftment in ...
Chris Wells
@stemcellsystems.bsky.social

Can't get more Australian than a talk on marsupial pluripotent stem cells from Gerard Tarulli from the TIGGR labs @asscr.bsky.social #ASSCR2025 - describing iPSC from the fat tailed Dunnart. tigrrlab.science.unimelb.edu.au

tigrrlab.science.unimelb.edu.auThylacine Integrated Genomic Restoration Research Lab | TIGRR LABOur mission: Marsupial conservation and de-extinction of the thylacine Over the past decade, the concept of de-extinction has transitioned out of the realm
Chris Wells
@stemcellsystems.bsky.social

Deep learning / autoencoder models of early development, recently published in @natmethods.nature.com pmc.ncbi.nlm.nih.gov/articles/PMC... #ASSCR2025

pmc.ncbi.nlm.nih.govDeep learning-based models for preimplantation mouse and human embryos based on single-cell RNA sequencingThe rapid growth of single-cell transcriptomic technology has produced an increasing number of datasets for both embryonic development and in vitro pluripotent stem cell-derived models. This avalanche of data surrounding pluripotency and the process ...
Chris Wells
@stemcellsystems.bsky.social

New from the lab - How FAIR is metadata for human pluripotent stem cells? Registered cell lines are more likely to be cited, shared and reused across different studies - but most lines are difficult to find or lack key information. Stem Cell Reports www.cell.com/stem-cell-re...

cell.comHow FAIR is metadata for human pluripotent stem cells?In this article, Wells and colleagues present the first systematic FAIR evaluation of stem cell data infrastructures. Case studies from, but not limited to, the United States, Japan, Europe, and Austr...
Chris Wells
@stemcellsystems.bsky.social

The human cell atlas #HCA2025GM really showcases descriptive science at scale - an atlas of human cells that engages globally. It's an exciting grass roots project. Equity and capability building are a core principle - as are coordinated networks focused on tissue specific atlases.

Chris Wells
@stemcellsystems.bsky.social

Consortium priorities - integrate the atlases into a whole body view; create 2D/3/D spatially resolved atlases and 3/ build global representation including for disease networks to benefit global health.

Chris Wells
@stemcellsystems.bsky.social

The human cell atlas #HCA2025GM really showcases descriptive science at scale - an atlas of human cells that engages globally. It's an exciting grass roots project. Equity and capability building are a core principle - as are coordinated networks focused on tissue specific atlases.

Chris Wells
@stemcellsystems.bsky.social

The human cell atlas #HCA2025GM really showcases descriptive science at scale - an atlas of human cells that engages globally. It's an exciting grass roots project. Equity and capability building are a core principle - as are coordinated networks focused on tissue specific atlases.