Jake Wintermute

Jake Wintermute

@synbio1.bsky.social

Synthetic Biologist - Foundry Theorist foundrytheory.substack.com stay humble biodesigners

1.8K followers428 following854 posts

“AI can’t possibly know everything about biotech because some of it is tacit knowledge you can only experience first hand.” The tacit knowledge:

Jake Wintermute reposted

gonna turn this into a midi controller and make some of the worst music you've ever heard in your life

Jake Wintermute@synbio1.bsky.social

I'd like to get a 90s-era medical device console like this and install some kind of AI soundboard in it so it can be my sassy lab companion

So funny when preclinical biotechs sign these big biobucks deals. Oh you're going to get a 20% royalty on annual net sales exceeding $1 billion? Buddy the fog is gonna consume us in 2027. The fog is coming. The fog is coming. The fog is coming

I am literally begging you to start a biotech company, literally any biotech company, and incorporate slop maximalism into your branding I am in love with biotech slop maximalism. I will do free work for you. I will shill whatever bioproduct or AI model thing you sell.

1) Apparently snails can eat graffiti 2) Apparently snails actively seek out graffiti to eat 3) ??? 4) Start a biotech company that sells snails for graffiti removal

Jake Wintermute reposted

Very proud of this work and all the efforts from my team and collaborators on this! You can now use DGRs for in vivo targeted hypermutagenesis in E. coli. We also included some early proof of concept in Yeast thanks to @seth-shipman.bsky.social !

Raphael Laurenceau@raphael-microb.bsky.social

🔈Paper out! We turned the most fascinating phage host-switch mechanism, diversity-generating retroelements, into a programmable mutagenesis tool, DGRec. You can perform targeted hypermutation of any 50-200bp sequence directly in vivo in E. coli www.nature.com/articles/s41...

Cloud computing is a good product: versatile, scalable, on-demand. Biotech service providers have tried to reproduce this formula. But what if we’ve been focusing on the wrong features?

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Cloud computing is a good product: versatile, scalable, on-demand. Biotech service providers have tried to reproduce this formula. But what if we’ve been focusing on the wrong features?

“Cloud labs” focus on versatility. A cloud compute server can do anything a computer can do. An analogous biology service would need to execute all possible biology lab protocols - a profoundly ambitious vision.

Biology services that are less versatile, but still scalable and on-demand, have proven value. DNA synthesis, strain banking and plasmid sequencing providers have accelerated science and found many happy customers.

We know that AI increases the value of human biological data. But by how much? Super interesting to see a specific class of human biological data assigned a spot price in a real market event

Me when I click on an in-line citation in an online article and it takes me to the references section of the same article instead of opening the new article in a new tab

If you had an LLM from the year 3000 and a writer's room of all the greatest communicators in history you could never invent a more worthless and confusing name for a statistical technique than "Design of Experiments"

This vintage Abcam fridge magnet does me so right It’s odd, it’s playful, it’s memorable. But what I like best is the way you can tell if reflects a real human’s sense of humor. It wasn’t designed by committee. More marketing like this please biotech companies

My son's school has scheduled the dungeons and dragons club, the chess club and the programming club all at the same time and I'm just trying to figure out how this could have happened