Gabriel Victora

🦑

Trabalhadores e trabalhadoras do Brasil, uni-vos. Nós merecemos respeito.

Very happy to share that I have been awarded a CRI Postdoctoral Fellowship from the Cancer Research Institute. Grateful for the support and excited for what’s ahead.

In the age of scientific misinformation & disinformation, we decided to invest in to create a scientific magazine that is curated using professional journalists and media communicators to highlight excellence of African science and innovation! Access the full magazine online at: ceri.africa/the-gem/

Odd choice of accomplishments

Fitness Race: Modelling antibody evolution by replaying a monoclonal germinal centre reaction over a 100 times 📷 William DeWitt, Ashni Vora, Tatsuya Araki et al @victora.bsky.social @rockefeller.edu @matsen.bsky.social in @cp-cell.bsky.social ➡️ bpod.org.uk/archive/2026... + John Ankers

2/ Meet Awardee Noah Palm. He’s setting out to uncover how the gut microbiome & immune system have co-evolved--he thinks that antibodies aren’t just for defense but are actively shaping the evolution of our commensal gut microbes 🦠. 🥳 Congrats Dr. Palm! @yale.edu 🙏 #HFScout @victora.bsky.social

The @victora.bsky.social lab at Rockefeller has turned germinal centers into a living laboratory for one of biology's oldest questions: how much of #evolution is shaped by chance? Learn more in this Q&A with Victora and graduate fellow Ashni Vora: https://bit.ly/4fB23bm

This was one of the most complex projects I have ever been involved in. Took us the better part of a decade, but I thoroughly enjoyed every minute of it. Especially the intensive and extensive interactions with @wsdewitt.github.io, @matsen.bsky.social, and @tylernstarr.bsky.social

This is what I call #combination of #artistry #science #romanticism on #Germinal #centers (I know I am a #Tcell fanatic!)-cool paper by @victora.bsky.social www.sciencedirect.com/science/arti...

Read our latest preprint. A window into GC clonal evolution upon boost.

You're entitled to your own opinion. You're NOT entitled to your own facts. #BelieveTheScience What he said 💯 👇 👇 👇

Someday, When the madness is done, And there is a true accounting, Of the lives that were saved, And those that were lost, I know we will find the name of Ralph Baric On the right side of the ledger. I, for one, am grateful.

📢🎉@hhmi-science.bsky.social HHMI competition for the next cohorts of #HannaGray Fellows and #FreemanHrabowski Scholars opening 11/3/2026. Senior postdocs and faculty within 7 years of appointment. Up to $10M over 10 yrs, + salary & benefits. Spread the word and consider applying! bit.ly/4vhC0LA

Separating selection from mutation in antibody language models buff.ly/qPXRv13?utm_...

Except in GCs theonion.com/biologists-c...

⏰ 🏃‍➡️A quick reminder that the abstract submission & early bird registration deadline for AIRR Community Meeting VIII: Decoding and Recoding Immunity is April 15. 🔗 tinyurl.com/airrcmeeting8 #airrc8 #immunosky

Spoiler alert: you have to treat the organism. & people who think in silico approaches are ready to replace animal models should not be included in adult conversations (ppl who want to develop them, very welcome, it's those who think they are ready for prime time that need to fuck all the way off)

In my simple brain, it's exciting but you need to understand the limitations: cell free systems allow you to ask q's about molecules; in vitro systems allow you to ask q's about molecules & cells; organoids may one day allow you to ask q's about mols, cells, and tissues/organs - but never organisms

Or have a listen to my convo with Tasuku Honjo & Pierre Golstein, whose labs discovered PD1 and CTLA4 respectively, and imagine a scenario where this is worked out with the current non-animal methods www.embo.org/podcasts/fro...

We are not really there yet, not even close. The most valuable (in market terms) drugs out there today come fm understanding the incretin effect, the unexpected finding that oral & iv glucose provoke different insulin response. Can you see a road to that from any of the current animal alternatives?

Happy to present Gloss, our new computational method for the analysis of multi-modal LIPSTIC + scRNA-seq data coupling cell-cell interaction measurements with intracellular transcriptomes. Paper: doi.org/10.1016/j.cr... Led by an amazing PhD student Tamjeed Azad, with @victora.bsky.social

Save the date! www.keystonesymposia.org/conferences/...

'Here, we discover functional adaptation of resident lymphocytes within two distinct skin stem cell niches and show that through this communication, each niche adjusts to meet diverse tissue demands.' #Preprint #Immunology www.biorxiv.org/content/10.6...

A study from @danmucida.bsky.social and @victora.bsky.social showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of #foodallergies. #RockefellerScience #YearInReview 🔗: https://bit.ly/4hyS18b

Zincfinger

In @natureportfolio.nature.com: Researchers, including Rockefeller's own Gabriel Victora (@victora.bsky.social), are striving to understand the impact a phenomenon known as original antigenic sin has on immunity to the virus that causes the flu.

Congrats on a very important paper!

Secret to great science: find the absolute best collaborators 👇👇

Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows

@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation www.biorxiv.org/content/10.1... @ucberkeleyofficial.bsky.social

@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses www.biorxiv.org/content/10.1... @thelundlab.bsky.social @nyulangone.bsky.social @carlanowosad.bsky.social

Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...

Renewing my yearly bet on Cooper/Miller for the Nobels. One might think that I would learn after being wrong so many times, but one would be mistaken. laskerfoundation.org/winners/b-an...

@cyrilpedia.bsky.social is biased, I’ve grilled him too many steaks

Congratulations to all, especially Rockefeller's @veenapadmanaban.bsky.social, a research associate in @sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!

2/ Did adaptive immune cells learn to cooperate before the modern immune system existed? Awardee @affinityborn.bsky.social may redefine what's essential for immune memory & enable alternative immune architectures. 🥳 Congrats Dr. Wesemann! @harvardmed.bsky.social 🙏 #HFScout @victora.bsky.social

In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵

In the minority here, but I think it would be refreshing and I'd appreciate reading a piece like "On the value of reductionist science". While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.