weigangcui.bsky.social

Association cortex connected to the striatum (esp. prefrontal) is more chained (catenated) than parietal regions belonging to the DMN (e.g. angular gyrus) and context-association network (CAN), with FC to the hippocampus. Why? what's the processing difference? www.biorxiv.org/content/10.6...

Function & cytoarchitecture don't overlap ... they're orthogonal. Prefrontal cortex is plastered with chains of functional patches previously mostly known from face processing. Why multi-modal parcellations are wrong ... and other insights hidden by group-averaging of fMRI data. great explainer👇🏻

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

Thrilled to announce our new paper in @natneuro.nature.com! We managed the impossible: precision functional mapping during #DBS, with 11.7h fMRI/patient. Selective DBS-induced deactivations in the SCAN, building on our recent @nature.com paper. nature.com/articles/s41... @ndosenbach.bsky.social

It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalizing SCAN connectivity represents a shared mechanism across diverse effective therapies. rdcu.be/e2n4t @ndosenbach.bsky.social @gordonneuro.bsky.social

A recently discovered brain network that links cognition and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study in Nature. go.nature.com/49VBuKI #Neuroskyence 🧪

A recently discovered brain network that links cognition (thinking) and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study published in Nature: spklr.io/63320DMwOi #Neuroscience #Neuroskyence #Parkinsons 🧠 🧪

Game-changer for PD therapy! Our @Nature study shows targeting the SCAN network with non-invasive brain stimulation doubles efficacy—no surgery needed. #Therapy #BrainScience #HealthTech nature.com/articles/s41...

Nature research paper: Parkinson’s disease as a somato-cognitive action network disorder go.nature.com/4aemciV

The highlight of my week was the publication of "Parkinson’s disease as a somato-cognitive action network disorder" in @nature.com. It's a great paper that shows how conceptual changes in fundamental neuroscience - the discovery of SCAN - can improve treatment 🧪 www.nature.com/articles/s41...

Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...

#Medsky🧪 #IDsky #Neurosky #publichealth @nature.com This study has redefined #ParkinsonsDisease (PD) as a disorder of the Somato-Cognitive Action Network (SCAN), a brain system that integrates whole-body movement, cognition, and internal physiological states www.nature.com/articles/s41...

A recently discovered brain network that links cognition and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study in Nature. go.nature.com/49VBuKI #Neuroskyence 🧪

More excellent reporting by NPR's Jon Hamilton about a new brain network that explains symptoms of Parkinson's that have befuddled brain researchers for decades. Kudos to @jianxunren.bsky.social and Hesheng Liu for this groundbreaking research in the journal Nature! doi.org/10.1038/s415...

In case this important point gets overlooked: along with our Nature paper, we’ve publicly released two large and scarce datasets—PIPD and PIET. IMHO, these are the best open Parkinson's and Tremor datasets available to date. See threads (1/4) 👇 nature.com/articles/s41...

Don’t miss out reading about this amazing work linking the SCAN to Parkinson’s disease. What are the best ways we could use this new knowledge?!

Researchers propose that the somato-cognitive action network (SCAN) "hyperconnectivity is central to PD pathophysiology & its alleviation is a hallmark of successful neuromodulation"; #Parkinsons as a somato-cognitive action network disorder www.nature.com/articles/s41...

Ren, J., Zhang, W., Dahmani, L. et al. Parkinson’s disease as a somato-cognitive action network disorder. Nature (2026). doi.org/10.1038/s415...

This is a nice animation illustrating the key points in the Parkinson's SCAN paper about which I posted previously.

Good news for Parkinson's sufferers. These researchers should review recent papers on Essential Tremor. ET researchers have identified the back of the brain as the ET problem area, the same area identified as part of the Parkinson's problem. Potential for beneficial cooperation. (I have ET.)

Such a fascinating paper! Less than 3 years after the discovery of the new motor network (SCAN) interleaved between effector motor regions, SCAN is proving highly relevant for Parkinson’s! It offers potential to improve treatment and reduce symptoms non-invasively.

Fantastic work showint how SCAN is related to Parkinson’s disease. Much promise for the future of battling the disease! www.nature.com/articles/s41...

Washington University researchers scanned 863 patients and found that Parkinson’s is not just a motor disorder. It stems from hyperactivity in the brain’s somato-cognitive action network, and treatments work best when they calm this network. www.nature.com/articles/s41...

Parkinson’s disease has the fastest-growing prevalence of any neurodegenerative disorder worldwide go.nature.com/4r0xZsk

Really cool attempt to link together multiple neuromodulation methods (DBS, TMS, TUS) to understand the neural basis of Parkinson's disease.

Non-invasive brain surface stimulation targeting personalized SCAN alleviated symptoms in patients with Parkinson’s disease. See the videos below.(www.nature.com/articles/s41...)

www.nature.com/articles/s41... the original research article ... no paywall

Happy to share a short but super cool video that gives a quick overview of our Nature paper on the somato-cognitive action of netwokr in Parkinson's disease www.nature.com/articles/s41...

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment. www.nature.com/articles/s41...

Why are gliomas overwhelmingly found in the action-mode network (AMN)? Could its function be contributing or is it that its function lines up with gene expression & receptor patterns? Either way, it raises the possibility of using inhibitory neuromod of the AMN to treat gliomas. #cancerneuroscience