Marc Chevrette

Now out in @acs.org JACS Au, the manuscript by #BarbaraTerlouw et al. describing PARAS, a high-accuracy machine-learning algorithm to predict substrate specificities of nonribosomal peptide synthetase (NRPS) adenylation domains, key for estimating natural product structures from BGC sequence. 1/n

See a brief review summarizing the use of synthetic microbial communities (SynComs) for revealing the ecology of specialized metabolites [my holiday break writing exercise] portlandpress.com/essaysbioche... #MicrobiomeEcology at Institute of Biology Leiden (IBL)

On Wisconsin

Bryan Cranston is Gordon Lightfoot

Icon @johandelsman.bsky.social

This is how we started implementing the similarity metric (GATOR Focal Scores) and how it actually turned out

GATOR-GC is out at @narjournal.bsky.social!! Check out our new targeted genome mining tool featuring a novel similarity metric to efficiently compare and deduplicate gene clusters. We uncover biosynthetic diversity missed by other genome mining tools academic.oup.com/nar/article/...

#ISBA2025 will be my official introduction in the Actino community. As we all look at understanding the diversity of these Microorganisms. I remain convinced that diversity drives discovery, from natural product discovery to human community. #PrideMonth #QueerInScience

Nice lunch with Bea Camara, @lore-fermar.bsky.social, @wildtypemc.bsky.social, Jordi Weijers and @evodivmet.bsky.social (not on photo) discussing microbes and their interactions #InternationalScience

Distinguishing among evolutionary and ecological processes shaping microbiome dynamics #ISMEJournal review by Tiffany N Batarseh and @bkoskella.bsky.social academic.oup.com/ismej/advanc...

If you are a PhD student in microbial interactions or natural products that is displaced by this political bullshit and looking for a new lab, I have room for one (or potentially two) PhD students in my group in the fall when I move to UW. Feel free to reach out via email.

In other words, when you ask for example “do vaccines cause autism?” you are looking for information about whether a thing in the world (a vaccination) produces an outcome (autism). But the LLM can only answer “what words could sound right after this?”

antiSMASH8: The Ocho Manuscript is out! doi.org/10.1093/nar/...

CeMiSt affiliated Caja Dinesen defended her PhD "Microbial signaling and secondary metabolites" Congratulations! With examiners Thomas Tørring @thomastorring.bsky.social, Lone Gram @lonegram.bsky.social, co-supervisor Thomas Ostenfeld Larsen, and supervisor Ákos T. Kovács@evolvedbiofilm.bsky.social.

All our #secmet and #ethnobotany people should come spread your #botany knowledge this summer!!

We put together this protocol in part to encourage broader adoption of Multiplexed Activity Metabolomics, an engine for functional metabolomics of all types including specialized metabolite discovery. We enjoy knowing if metabolite is active before isolating it, and so should you! #natprod

Well done, Wisconsin thehill.com/homenews/cam...

The Chevrette Lab has some big news. Beginning in August we'll be joining @uwmadscience.bsky.social in the Department of Plant Pathology and @widofficial.bsky.social Beyond excited for this new chapter. youtu.be/t-M09m-y1KU?...

A message sent to tonight to all UMass faculty reminding us that we sacrifice 1st and 4th amendment rights when we travel internationally, and warning that non-citizens put themselves at risk when traveling. I’m glad for the warning & but pissed that this is where we’re at.

New preprint collab with the Zhou lab! www.biorxiv.org/content/10.1... Learning gene interactions and functional landscapes from entire bacterial proteomes

🎉We are delighted to welcome @tilmweber.bsky.social from the Technical University of Denmark to the @natprodreports.rsc.org Editorial Board! Learn more about Tilmann here🔽 blogs.rsc.org/np/2025/03/1...

I don't usually get much email about my #MattersMicrobial podcast, which is okay. But I had a PhD student in Brazil just write to me, thanking me for a prior podcast I did with @wildtypemc.bsky.social on genome mining, which she found useful. That made me happy.

Anyone have a good way to bulk backup a full Outlook 365 email account (with attachments)?

August 2014:

Congratulations to Claudia Solís-Lemus! The Bassam Z. Shakhashiri Public Science Engagement Award recognizes one University of Wisconsin–Madison faculty member and one academic staff member for excellence in engaging the public with STEAM (Science, Technology, Engineering, Arts, and Math) research.

Nice little Friday

Preprint for @wildtypemc.bsky.social 's GATOR-GC is out! Have been looking forward to using this to explore secondary metabolite BGCs! www.biorxiv.org/content/10.1...

Extending my grant update this morning. Here are data limited to new and competitive renewal applications. The Pause is dead, Long live the Pause...

This is a game changer .... Will hardly look back after using it!

GATOR-GC preprint is live! If you haven't already, check out our new tool for targeted gene cluster mining. @jcedielbecerra.bsky.social doi.org/10.1101/2025...

A large part of what we chatted about comes from the awesome work of @cumsille.bsky.social. Check it out!

Thursday: time for #MattersMicrobial Episode #81! Dr. Marc Chevrette talks about genome mining, secondary metabolites, and why microbes are the very best chemists. Please share the #GoodMicrobialWord. @profvrr @wildtypeMC youtu.be/QYGiAc4lRsk?...

Movie you've watched more than 6 times, gifs only

Out today in Angewandte Chemie Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides doi.org/10.1002/anie... Fun collaboration with the Tørring lab @thomastorring.bsky.social @tizianasvenningsen.bsky.social @amerrild.bsky.social

What the shit "For FY26 we are told about plans to reduce the NSF budget by 50%-75% - such reduction will mean no new awards for at least a year, elimination of divisions, merging of programs." nanoscale.blogspot.com/2025/02/the-...

Really fun podcast with Marc Chevrette on genomic mining and why microbes are the very best chemists. @wildtypemc.bsky.social

Matters Microbial Podcast recording done! Thanks @markowenmartin.bsky.social for the invite to share a little of our work and chat mining microbial genomes/interactions.

perl -p -i -e 's/(\$\d+)M/${1} .B/g' doge.csv

Gaining insights into the complexity of specialized metabolites and their possible ecological roles These metabolites not only function as antimicrobials, but also as cue molecules among other peculiar functions -see our paper in microLIFE of @femsjournals.bsky.social on surfactin and subtilosin A

"Make America Great Again. Make America Healthy Again. These were promises made by candidate Trump in his campaign to be president of the United States of America. What in this campaign platform should have prepared us for a war on discovery?"

"This is the time for all citizens, scientists, the executive branch and Congress to join forces and strengthen the research engine." - @johandelsman.bsky.social wisconsintechnologycouncil.com/guest-column...

22 states starting the IDC legal battle AZ, CA, CO, CT, DE, HI, IL, MA, ME, MD, MI, MN, NC, NJ, NM, NV, NY, OR, RI, VT, WA, WI www.statnews.com/2025/02/10/n...

Multi-omic analyses unveil contrasting composition and spatial distribution of specialized metabolites in seeds of Camelina sativa and other Brassicaceae pubmed.ncbi.nlm.nih.gov/39908193/

We're delighted to announce Fidele Ntie-Kang (University of Buea) as the winner of the 2025 Natural Product Reports Emerging Investigator Lectureship! 🎉 Read more about Fidele and his research here: blogs.rsc.org/np/2025/02/0... #NatProd #PlantScience

Julian is truly one of the great minds of our time. His work inspires everything I do in my own. I consider myself very lucky for having met him briefly and to have sat in on many a seminar.

Manuscript submitted. I declare this week officially over.

Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.

UF just canceled classes tomorrow because of the cold. It's 43F (6C).