Wiseman Lab

🚨TT Assistant Professor search!🚨 Scripps has a broad search for an assistant professor in Chemistry, Immunology & Microbiology, Integrative Structural & Computational Biology, Molecular & Cellular Biology, Translational Medicine, or Neuroscience. Join us on the Mesa! apply.interfolio.com/195438

Metabolically Activated Proteostasis Regulators Reduce Differentiation of CD4+ TH17 Cells https://www.biorxiv.org/content/10.64898/2026.09.02.747634v1

*JobAlert* One more week to apply for a post-doc position in my lab at Dundee to study co-translational protein quality control of secretory and membrane proteins. This is a collaborative project with @kulathu.bsky.social and @zeqiraj.bsky.social www.jobs.ac.uk/job/DSM201/p...

Our lab has a new preprint out! If you are interested in how viral infections reprogram maternal tissues to promote protection of offspring after birth, take a look! www.biorxiv.org/content/10.6...

Check out this new preprint from Nancy Cheong, a joint student with @thepenkpanther.bsky.social . No idea how I got involved with this project but it sure was fun ‘being in the room where it happened’ with those two rock stars! www.biorxiv.org/content/10.6...

Cryo-ET is often framed as a tool for in situ protein structure. But what if the real revolution is contextualization? I explore how #teamtomo is redefining what "local" means in organelle biology, revealing membrane states rather than just protein structures. tinyurl.com/localmembrane

The Lippi lab is hiring a postdoctoral associate! We built new technologies to study post-transcriptional regulation in the healthy and diseased brain. We are recruiting motivated and talented scientists who will use these tools to discover new biology and new therapies.

We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...

Excited to share that our lab’s first preprint is now available! This work reflects a huge effort from graduate student Abeera Mehmood and coauthors! If you are interested in what B cells make all antibodies against norovirus take a look! www.biorxiv.org/content/10.6...

🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp

I’m excited to share that our review article, co-authored with my colleague Dr. Decio Eizirik, is out today in Science Translational Medicine. www.science.org/doi/10.1126/...

Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling https://www.biorxiv.org/content/10.64898/2026.02.17.706344v1

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis https://www.biorxiv.org/content/10.64898/2026.02.01.703113v1

New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇 www.biorxiv.org/content/10.6...

One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org www.embo.org/people/revie...

De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response https://www.biorxiv.org/content/10.64898/2025.12.22.695711v1

JCB’s Cover of the Year voting is open! I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬 #teamtomo @attychang.bsky.social

In collaboration with @enginlab.bsky.social, Khahani Eynullazada, a grad student from @sroyyors.bsky.social Lab identified gene regulatory networks capturing shared and perturbation-specific stress pathways in Type 1 diabetes using GRN inference tools on scRNA-seq data from in vivo mouse models.

If you're at #CellBio2025, please join us tomorrow at 9AM in Room 122 for a fantastic speaker lineup at the #EndoplasmicReticulum Minisymposium! Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz! @ascbiology.bsky.social

Postdoc position available in my lab in Jena (Germany. jobs.leibniz-fli.de/jobposting/6... If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.

Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756

🚨 #teamtomo!🚨 Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??

New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇 www.biorxiv.org/content/10.1...

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩 @zidlab.bsky.social @tomo.science @hamid13r.bsky.social

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy www.life-science-alliance.org/content/8/6/...

OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs." www.sandiegouniontribune.com/2025/02/25/o...

Excited to be involved in this cool project led by @yananchenlab.bsky.social and her team showing protection afforded by the ATF6 activator AA147 in a mouse model of multiple sclerosis. Check it out! 👇

1/ 🚨We’re thrilled to share our latest study: "Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟 www.biorxiv.org/content/10.1... How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️

A huge week for Prakhyat, our joint @scripps.edu student with the @wisemanlab.bsky.social! He was awarded an AHA earlier in the week and today he passed his PhD candidacy exam! Because Prakh is so chill, we celebrated with chocolate-coffee liquid nitrogen ice cream. 😎

Congrats to our amazing @scripps.edu grad student Prakhyat Mathur (joint with @wisemanlab.bsky.social) for being awarded a predoctoral fellowship from the AHA @americanheart.bsky.social. Prakh will be investigating how mitochondrial stress activates the integrated stress response. Well-earned Prakh!