Feyza Engin

Feyza Engin

@enginlab.bsky.social

Associate Professor @University of Wisconsin-Madison. Previously Harvard University & Baylor College of Medicine. www.enginlab.org

503 followers289 following20 posts

Feyza Engin reposted

Wisconsin Institute for Discovery
@widofficial.bsky.social

In collaboration with @enginlab.bsky.social, Khahani Eynullazada, a grad student from @sroyyors.bsky.social Lab identified gene regulatory networks capturing shared and perturbation-specific stress pathways in Type 1 diabetes using GRN inference tools on scRNA-seq data from in vivo mouse models.

news.wisc.eduHow disabling one gene protects mice against Type 1 diabetesUW–Madison researchers have discovered a mechanism that could one day help people at risk of developing the metabolic disease.

Feyza Engin reposted

Daniel Drucker
@danieljdrucker.bsky.social

Inflammation, unfolded protein response, and secretory hormone processing create #T1D epitopes in human cytokine-treated #islets www.cell.com/cell-reports...

cell.comThe antigen presentation landscape of cytokine-stressed human pancreatic isletsNanaware et al. characterize peptides presented by MHC proteins in inflamed human pancreatic islets and test them for reactivity with CD4 and CD8 T cells from patients with T1D. These results identify...
Feyza Engin
@enginlab.bsky.social

Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication: Cell Metabolism www.cell.com/cell-metabol...

cell.comLocalized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communicationTong et al. utilize advanced imaging approaches to reveal that beta cells located next to alpha cells are specially adapted as glucagon sensors by virtue of their high expression levels of GLP1R. Thes...

Feyza Engin reposted

Daniel Drucker
@danieljdrucker.bsky.social

The combination of verapamil and low-dose mATG outperformed monotherapy in reversing recent-onset type 1 #diabetes in NOD mice #T1D @diabetologiajnl.bsky.social link.springer.com/article/10.1...

link.springer.comVerapamil and low-dose anti-mouse thymocyte globulin combination therapy stably reverses recent-onset type 1 diabetes in NOD mice by acting on the beta cell and immune axes - DiabetologiaAims/hypothesis Verapamil, a calcium channel blocker, and low doses of anti-thymocyte globulin (ATG) have individually shown efficacy in preserving beta cell function in people with recent-onset sympt...

Feyza Engin reposted

Ian Weissman, DO
@drianweissman.bsky.social

About 1 in 3 young people who are 12 to 17 years old have prediabetes, new national data show, putting them at risk not just for type 2 diabetes but also for heart disease and stroke. www.statnews.com/2025/07/09/p...

statnews.comNearly 1 in 3 teens have prediabetes, CDC finds, in ‘wake-up call’Nearly 1 in 3 American adolescents have prediabetes, a CDC report finds. An official notes "it’s not too late to change course."

Feyza Engin reposted

Helena Cocheme
@cochemelab.bsky.social

🎉Excited to share our latest paper, published in Nature Communications!🎉 "Enhancing autophagy by redox regulation extends lifespan in Drosophila" #redox #metabolism #ageing #Drosophila @natcomms.nature.com @mrc-lms.bsky.social doi.org/10.1038/s414...

doi.orgEnhancing autophagy by redox regulation extends lifespan in Drosophila - Nature CommunicationsRedox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Feyza Engin reposted

Wiseman Lab
@wisemanlab.bsky.social

New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇 www.biorxiv.org/content/10.1...

biorxiv.orgDrug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient CellsPathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...

Feyza Engin reposted

Stephen O'Rahilly
@stephenorahilly.bsky.social

Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?

nature.comMice lacking this amino acid lost 30% of their body weightBut eliminating cysteine, which is found in high-protein foods, from human diets would be challenging.

Feyza Engin reposted

Brandon Chen, PhD
@brandontwchen.bsky.social

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! www.sciencedirect.com/science/arti...

sciencedirect.comMitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasisMitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…

Feyza Engin reposted

Denis Wirtz
@deniswirtz.bsky.social

Be on the lookout for a new paper from the lab: "iCLAP: A high-plex immunostaining with high sensitivity for co-detection of low-abundance antigens". In this paper, we introduce ICLAP to detect and spatially map low-abundance proteins, such as senescence markers, in FFPE tissue sections.

Feyza Engin reposted

Molecular Cell
@cp-molcell.bsky.social

Online Now: STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders Online now:

dlvr.itSTING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disordersSTING signaling in the innate immune system is well known for its role in the antiviral type I interferon response. Tang et al. find that STING acts as an immune sensor of lysosomal activity. When the lysosome becomes defective, STING is activated and exerts a dual function that induces both immune signaling and lysosomal biogenesis.

Feyza Engin reposted

Iain Cheeseman
@iaincheeseman.bsky.social

New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below. www.biorxiv.org/content/10.1...

biorxiv.orgAlternative start codon selection shapes mitochondrial function during evolution, homeostasis, and diseaseMitochondrial endosymbiosis was a pivotal event in eukaryotic evolution, requiring core proteins to adapt to function both within the mitochondria and in the host cell. Here, we systematically profile...
Iain Cheeseman@iaincheeseman.bsky.social

Countdown to an epic new pre-print. Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!

Feyza Engin reposted

Andrea Galmozzi
@andreagalmozzi.bsky.social

Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social

Dylan Duerre@dylanduerre.bsky.social

Excited to share that work from my PhD is now available in @natmetabolism.bsky.social! Here, we uncover a link between heme production, BCAA metabolism, and thermogenesis—implicating heme synthesis in #aging, #obesity, and #T2D. Link to paper: urldefense.com/v3/__https:/... A Thread (1/15)

urldefense.comHaem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissueNature Metabolism - Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs...

Feyza Engin reposted

DeBerardinis Lab at UT Southwestern Medical Center
@rjdlab.bsky.social

www.quantamagazine.org/how-metaboli... Seems like a good time to remind you of an upcoming meeting on this exact topic: www.keystonesymposia.org/conferences/...

quantamagazine.orgHow Metabolism Can Shape Cells’ Destinies | Quanta MagazineA growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.

Feyza Engin reposted

Daniel Drucker
@danieljdrucker.bsky.social

Modulating the liberation of miR-503-322 which is secreted as small extracellular vesicles from senescent β-cells, to enter and damage exocrine acinar cells may provide preventive and therapeutic strategies for aging-associated pancreatitis @naturecomms.bsky.social www.nature.com/articles/s41...

nature.comEndocrine-exocrine miR-503-322 drives aging-associated pancreatitis via targeting MKNK1 in acinar cells - Nature CommunicationsAging is the risk factor for chronic pancreatitis and its acute attack. Here, the authors show that exocrine acinar cells received endocrine β-cell-derived miR-503-322 and caused pancreas autodigestio...

Feyza Engin reposted

jobRxiv
@jobrxiv.org

Replying to @jobrxiv.org

▶️ Postdoctoral Fellow Position in Cell Stress/Senescence UNIVERSITY OF WISCONSIN-MADISON @EnginLaboratory jobrxiv.org/job/univ... ▶️ Post-doctoral Fellow in Leukemia Research Saint-Louis Research Institute, INSERM U944 @LabPuissant jobrxiv.org/job/sain... #Sciencejobs #AcademicSky 3/8

jobrxiv.orgPostdoctoral Fellow Position in Cell Stress/SenescencePost a job in 3min, or find thousands of job offers like this one at jobRxiv!

Feyza Engin reposted

Daniel Drucker
@danieljdrucker.bsky.social

Endocrine dysfunction and #diabetes is promoted by β cell dedifferentiation and loss of cellular identity in people with Wolfram syndrome, and ameliorated by inhibition of TXNIP #islets #genetics www.science.org/doi/10.1126/...

science.orgβ cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndromeβ cell dedifferentiation underlies diabetes mellitus in Wolfram syndrome, and Txnip inhibition prevents β cell regression in Wfs1-deficient mice.

Feyza Engin reposted

Cristian Prieto-Garcia
@prieto-garcia.bsky.social

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...

doi.orgPathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagyRNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
Feyza Engin
@enginlab.bsky.social

If you are interested in studying senescence, immune surveillance, and the cell stress pathways multiple positions are open in my lab. jobs.wisc.edu/jobs/researc... jobs.wisc.edu/jobs/scienti...

jobs.wisc.eduResearcher I - Madison, Wisconsin, United StatesJob Summary: The Researcher will work with the principal investigator and graduate students or postdocs in the Engin Lab within the Biomolecular Chemistry Department to establish a robust research p...