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The hole in the Ozone. Awareness and regulation are working. The hole is the smallest it's been since discovered in the 80s and the UN now projects that under the current regulations the ozone layer will completely regenerate by 2045.

PFAS still suck. I'm swimming in them (from a completely different source than refrigerants). I did hear once about someone working on a replacement that was neither GHG nor PFAS, but dunno the status of that today.

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Also, while I will always bemoan the addition of PFAS to refrigerants as a counter to "but we saved the ozone," we do tend to put PFAS in everything else anyway. My local fire dept just spent gazillions replacing pumps, hoses and nozzles when switching away from PFAS foam. This'll cost us.

I can't speak to other industries, but regarding the domestic heat pumps I work on, the PFAS refrigerants (eg R410a which is a blend including PFAS HFC125) are phased out. We moved to R32 a few years back, which is non-PFAS but still has a relatively high GWP.

We're now moving to R290, which is just propane (non-PFAS & low GWP). It's actually thermodynamically better than its predecessors, but the biggest problem I'm having is that the guidance on flammability precautions is unclear.

For the monobloc systems I install I really feel that the regulations should be pretty limited, as the units only contain ~1.5kg propane, which remains outside the building. In a world where we pipe continuous methane into houses we need to stop making perfect the enemy of the good.