Snezhka Oliferenko

Snezhka Oliferenko

@alebenoit.bsky.social

https://www.kcl.ac.uk/people/snezhana-oliferenko

650 followers274 following181 posts

Snezhka Oliferenko
@alebenoit.bsky.social

Incredibly myopic from the funders - governments must support this essential infrastructure

PomBase: The S. pombe knowledgebase @pombase.bsky.social

We’re defunding the infrastructure modern biology runs on. PomBase, FlyBase and HGNC; named critical global resources; have all faced funding crises since 2024. Experimental analysis & interpretation and AI models depend on resources like these. Our new paper @GeneticsGSA 👇
doi.org/10.1093/gene...

doi.orgValidate User
Snezhka Oliferenko
@alebenoit.bsky.social

Guys! @jbahler.bsky.social and I are recruiting a PhD student in this round - if you know great undergrads or Masters students please tell them about us! And Crick in general, of course ;) Thank you!!

The Francis Crick Institute@crick.ac.uk

PhD recruitment is now open at the Crick, and we're looking for people to join a community of researchers tackling big scientific questions in the heart of London. Apply by 3 November: www.crick.ac.uk/careers-and-... Find out more about the three routes into our 2027 PhD programme in this thread ⬇️

crick.ac.ukPhD studentsOur PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.

Snezhka Oliferenko reposted

Mathilda Lennartz
@mathilda95.bsky.social

UPDATE!: I am absolutely stoked that the second paper of my PhD is now out in @natcellbio.nature.com :D. We combined lipid imaging, STED microscopy, and mathematical modelling in a super cool team effort to quantify lipid partitioning inside clathrin-coated pits. www.nature.com/articles/s41....

nature.comQuantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell BiologyLennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
Snezhka Oliferenko
@alebenoit.bsky.social

People!!! This workshop will be ACE - please share, please apply!

The Company of Biologists@biologists.bsky.social

Applications are now open for early-career researchers to apply for a funded place at our Workshop on Membrane Function: Insights from Cellular Diversity and Evolution, organised by Snezhana Oliferenko @alebenoit.bsky.social & Cunqi Ye. Find out more and apply www.biologists.com/workshops/ju...

Snezhka Oliferenko reposted

Liz Miller
@lizmillercu.bsky.social

*JobAlert* One more week to apply for a post-doc position in my lab at Dundee to study co-translational protein quality control of secretory and membrane proteins. This is a collaborative project with @kulathu.bsky.social and @zeqiraj.bsky.social www.jobs.ac.uk/job/DSM201/p...

jobs.ac.ukPostdoctoral Research Assistant - UOD2336 at University of DundeeDiscover an exciting academic career path as a Postdoctoral Research Assistant - UOD2336 at jobs.ac.uk. Don't miss out on this job opportunity - apply today!

Snezhka Oliferenko reposted

Irene Miguel-Aliaga
@irenemiguel-aliaga.bsky.social

Read about our latest work here www.cell.com/cell/fulltex... or let Alessandro tell you all about it (link below)!

cell.comThe sex and reproductive plasticity of intestinal muscles instruct gut sizeAdult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...
The Francis Crick Institute@crick.ac.uk

“I believe my findings are just the tip of a bigger iceberg.” Read more about the work from Alessandro, a postdoc in our Organ Development and Physiology Lab led by @irenemiguel-aliaga.bsky.social, who studied changes in the female intestine during and after reproduction: https://bit.ly/4bElX2u

Snezhka Oliferenko reposted

Kutay lab
@kutaylab.bsky.social

We are excited by the publication of our work on Torsin1A, its interaction partner CLCC1, and their role in membrane fusion during NPC biogenesis! A fantastic collaboration with @jagannathan-lab.bsky.social @labvanni.bsky.social @gautamdey.bsky.social and the Korkhov and Antonin labs!

cell.comThe dystonia-associated Torsin1A sustains CLCC1 function in membrane fusion of the nuclear envelope for NPC biogenesisMaslennikova et al. identify the ER membrane protein CLCC1 as an interaction partner of the dystonia-linked AAA+ ATPase Torsin1A. Torsin1A sustains the function of CLCC1, which is proposed to facilitate fusion of the nuclear envelope during NPC biogenesis by forming an oligomer that promotes lipid bilayer approach and remodeling.
Snezhka Oliferenko
@alebenoit.bsky.social

Brilliant Elisa!!!

King's Faculty of Life Sciences & Medicine@kingslsm.bsky.social

Dr Elisa Gomez Gil is a postdoctoral researcher @kingscollegelondon.bsky.social @crick.ac.uk. We spoke to Elisa to find out more about her recent paper in Genes & Development, her love for sport and cooking, and her hopes for the future: www.kcl.ac.uk/5-minutes-wi... @alebenoit.bsky.social

kcl.ac.uk5 minutes with Elisa Gomez GilDr Elisa Gomez Gil is a postdoctoral researcher in Professor Snezhana Oliferenko’s group in the Randall Centre for Cell & Molecular Biophysics at King’s College London and the Comparative Biology…
Snezhka Oliferenko
@alebenoit.bsky.social

Ahh the prettiest story 𑣲₍ ᐢ. .ᐢ₎

vjesticalab.bsky.social@vjesticalab.bsky.social

Why did the two gametes (egg♀️ and sperm♂️) start to become different? It's a strategy to optimize the costs and benefits of investing into offspring! Read our brand new @pnas.org story that finds a molecular mechanism behind this evolutionary idea proposed in 1972 by Parker, Bell and Smith.

doi.orgMeiotic cohesin Rec8 imposes fitness costs on fission yeast gametes favoring the evolution of parental bias in gene expression | PNASDifferences between partner gametes, which evolved repeatedly in eukaryotes, can contribute to the evolution of the sexes, sexual selection, and no...

Snezhka Oliferenko reposted

Jeremy Baskin
@jeremybaskin.bsky.social

Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪

Snezhka Oliferenko
@alebenoit.bsky.social

Wild and amazeballs

Luiz Pedro Carvalho, PhD@luizcarvalholab.bsky.social

We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.

nature.comMycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature CommunicationsHere, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
Snezhka Oliferenko
@alebenoit.bsky.social

Fission yeasts lookup

liti_nice@litinice.bsky.social

here is our first contribution of yeast in microbiomes led by Jason Tsai group[ with contributions from Alberto and Nelly: www.biorxiv.org/content/10.6... more to come

biorxiv.orgA global synthesis of yeast in microbiomesYeasts are widespread members of microbial communities across terrestrial, aquatic, and host-associated environments, yet they remain underrepresented in microbiome studies due to low abundance and me...
Snezhka Oliferenko
@alebenoit.bsky.social

Yay - and also thank you to the three reviewers! /)/) ( . .) ( づ♡

Gautam Dey@gautamdey.bsky.social

Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...

journals.biologists.comEvolutionary cell biology comes of ageSummary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
Snezhka Oliferenko
@alebenoit.bsky.social

Ahhh CUTE!!!

Buzz Baum@buzzbaum.bsky.social

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

Snezhka Oliferenko reposted

Eugene Makeyev
@emakeyev.bsky.social

Our paper describing enhanced hybridization-proximity labeling technology is finally out! Enhanced HyPro can identify proteins associated with small RNA compartments and even some individual transcripts, such as pathological C9orf72 transcripts: www.nature.com/articles/s41...

nature.comEnhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules - Nature CommunicationsSystematic discovery of proteins interacting with low-abundance RNAs is challenging. Here, the authors develop an enhanced HyPro technology to identify proteins associated with compact RNA compartment...

Snezhka Oliferenko reposted

Boris Sieber
@borissieber.bsky.social

Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction! Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1 doi.org/10.1101/2025...

Snezhka Oliferenko
@alebenoit.bsky.social

Ahh so beautiful

André Nadler@nadlerlab.bsky.social

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Snezhka Oliferenko
@alebenoit.bsky.social

Yay YAY congrats to everyone - and am super happy for my neighbour (and friend!) Jody Rosenblatt! Jody doesn’t have Bluesky, let me bug her about that

EMBO@embo.org

Welcome and congratulations to the 60 new members and 9 associate members who have been elected to the EMBO Membership! This honour celebrates #research excellence and outstanding achievements in the #LifeSciences. 🧪 Learn more here: www.embo.org/press-releas... #EMBOMembers2025

embo.orgOutstanding life scientists elected to the EMBO Membership – Press releases – EMBOSixty-nine new members join the community of leading life scientists in Europe and beyond
Snezhka Oliferenko
@alebenoit.bsky.social

OMG IN ALL CAPS

Max Haase@maxhaase.bsky.social

It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres” www.biorxiv.org/content/10.1...

biorxiv.orgAncient co-option of LTR retrotransposons as yeast centromeresThe evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...

Snezhka Oliferenko reposted

HittingerLab
@hittingerlab.bsky.social

Just out - a collaborative effort examining gene family evolution across yeast species. We found that fast-evolving yeasts lose more genes - especially ones for splicing, metabolism, and cell division. This is consistent with their narrow metabolic niche breadth. www.embopress.org/doi/full/10....

embopress.orgUnique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage | Molecular Systems BiologyimageimageLarge-scale comparison of gene families across 1154 Saccharomycotina genomes revealed that gene gains and losses drive yeast evolution. Faster-evolving lineages lose more genes and speciate ...
Snezhka Oliferenko
@alebenoit.bsky.social

Omg AMAZEBALLS

Tobias Warnecke@tobiaswarnecke.bsky.social

Joining the race to the bottom has never been cooler... www.biorxiv.org/node/4580343... www.biorxiv.org/content/10.1...

biorxiv.orgA cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genomeDefining the minimal genetic requirements for cellular life remains a fundamental question in biology. Genomic exploration continually reveals novel microbial lineages, often exhibiting extreme genome...

Snezhka Oliferenko reposted

Alex Holehouse
@alexholehouse.bsky.social

Now published! Big congrats to first author @gginell.bsky.social We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions. www.science.org/doi/10.1126/...

science.orgSequence-based prediction of intermolecular interactions driven by disordered regionsIntrinsically disordered regions (IDRs) in proteins play essential roles in cellular function. A growing body of work has shown that IDRs often interact with partners in a manner that does not depend ...
Alex Holehouse@alexholehouse.bsky.social

Excited to share new work from Garrett Ginell et al where we present an approach for predicting intermolecular interaction driven by disordered regions. We focus on how chemical complementarity can contribute to and even dictate intermolecular interactions www.biorxiv.org/content/10.1...

Snezhka Oliferenko reposted

Richard Sever
@richardsever.bsky.social

Non-profit journals are on the critical list. The cause: academics obsession with the Nature brand, coupled with the APC $ model. Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..

Seema Grewal@seemagrewal.bsky.social

Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is: “…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”

Snezhka Oliferenko
@alebenoit.bsky.social

😱💥❤️

Yeast Journal@yeast-journal.bsky.social

In the latest #Yeast research article of the series #FantasticYeasts, Pei-Jie Han, Feng-Yan Bai & team describe a new yeast species isolated from a Chinese forest: Saccharomycopsis yichangensis, that can prey on Saccharomyces cerevisiae and other yeasts 😲 onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.comSaccharomycopsis yichangensis sp. nov., a Novel Predacious Yeast Species Isolated From SoilSaccharomycopsis yichangensis sp. nov. occurs in soil from a subtropical forest in central China. This novel species is homothallic and produces asci containing four spheroidal ascospores, which can ...
Snezhka Oliferenko
@alebenoit.bsky.social

Good efforts. Here, I broke my tibia jumping in triumph after crossing the finishing line at a dog agility competition.

Simon Hammann@simonhammann.bsky.social

Broke my hand while shot putting Tore a ligament in my thumb while long jumping Ignited myself in the lab trying to test for borate

Snezhka Oliferenko
@alebenoit.bsky.social

Ahh what fun

Molecular Cell@cp-molcell.bsky.social

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay

dlvr.itRibosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decayZhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on codon optimality and conserved across species, establishes direct feedback coupling the translation of new proteins with the stability of the mRNA that encodes for them.