Alison Feder

Alison Feder

@alisonfeder.bsky.social

Rapid evolutionary dynamics in viruses, cancer and bacteria. Assistant professor at UW Genome Sciences and Freeman Hrabowski Scholar at HHMI. federlab.github.io

2.3K followers787 following128 posts

Alison Feder reposted

Early career faculty? #FreemanHrabowski Scholar applications open Nov. 3! In the words of current Scholar Claudia Moreno (@uwdeptmedicine.bsky.social), “Don’t think twice — apply." Register now to check your eligibility, preview the application, unlock additional resources, & more: bit.ly/fhs26.

Alison Feder reposted

I am so honored and excited to receive NIH Director's New Innovator Award for our lab!🌟 I am really grateful to our lab members and all mentors supporting me past and present. We are looking forward to exciting science we can do and relatedly, hiring at all levels!! newsroom.uw.edu/blog/3-from-...

newsroom.uw.edu3 from UW Medicine receive NIH New Innovator awards - UW Medicine | NewsroomNews and information for journalists
UW Genome Sciences@uwgenome.bsky.social

Congratulations to Saori Sakaue on receiving the 2026 NIH Director's New Innovator Award! commonfund.nih.gov/newinnovator...

I had a fantastic time working closely with Pleuni during my PhD! Strong endorse!!

Pleuni Pennings@pleunipennings.bsky.social

I am hiring a postdoc! Are you interested to work on population genetics/ drug resistance/ data? Want to work in Montpellier, France? Fastq files don't scare you? PhD required, start date hopefully Nov 1! (end date Sep 30 2028) Please share! abetterscientist.wordpress.com/2026/09/29/p...

Alison Feder reposted

Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.

Alison Feder reposted

Alison Feder reposted

I’m looking to hire an NIH funded postdoc to join our lab here at Davis (please RT). Ongoing areas of interest include: 1) polygenic signals of selection from time series, ARGs, GWAS, etc 2) The interpretation of GWAS, polygenic scores, & sources of confounding

Alison Feder reposted

Reposting this ongoing search (any discipline of biology) for an Assistant to Associate level colleague in the Division of Basic Sciences at Fred Hutch. Great city, great colleagues, great core facilities, great trainees.

Harmit Singh Malik@harmitmalik.bsky.social

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Alison Feder reposted

Junior faculty position in Basic Sciences @fredhutch.org! Please repost!

Fred Hutch@fredhutch.org

🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: https://apply.interfolio.com/190640

Alison Feder reposted

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

Alison Feder reposted

For those not able to make it to #socialviruses this year, Sam is live-tweeting all three days of talks, touching on all aspects of social evolution in viruses! #evosky #virosky 🧪 🦠 🔬

Sam Díaz-Muñoz (they / ella)@sociovirology.bsky.social

Hi Everyone! I will be broadcasting live from the Social Lives of Viruses 2026 conference @zoology.ubc.ca @ubcbiodiversity.bsky.social in beautiful Vancouver BC, organized by @asherleeks.bsky.social and myself with the support of Canadian Institutes of Health Research and @moorefound.bsky.social.

Concisely summarizes one of my favorite insights from @alexrob.bsky.social 's latest work!

Sam Díaz-Muñoz (they / ella)@sociovirology.bsky.social

@alexrob.bsky.social: Data suggest some viruses that emerge which do better on their own than in coinfection. They gain their advantage through mutations. Cooperators or singletons favored? Cooperators when their advantage is rare; mutations are rare when emerging #SocialViruses26

Alison Feder reposted

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

Major takeaways: HIV can fix escape mutations while retaining nearly all genetic diversity, and sweep signatures can be so soft as to be effectively invisible in genetic data (except at the exact site of escape itself). This totally blew my mind, even as someone who appreciates HIV mutability.

But what Elena found is that in 8/10 HIV populations, haplotype lengths were basically exactly the same before, during and after the sweep. It seems like these sweeps are basically so soft that they’re not changing the linkage structure of the population??

She ran HIV-matched forward simulations in SLiM and found that sweeps need to be spreading on 50 or more genetic backgrounds before they generate these types of signatures. Beyond that point, you can’t really tell because there’s not really any signature to see!

Our classical sweep signature is a loss of diversity surrounding the adaptive locus. Elena found that following 10-1074 escape, 10 HIV populations are basically just as diverse as they were before the sweep, and consistently *more* diverse at the adaptive locus itself.

Alison Feder reposted

Cannot be more excited about the lineup for the inaugural Function of Evolving Systems GRC conference I am co-organizing with the amazing Joy Bergelson. Less than a month away: August 9 - 14, 2026. Still a few spots left! And do check out the amazing list of speakers: www.grc.org/function-of-...

grc.org2026 Function of Evolving Systems Conference GRCThe 2026 Gordon Research Conference on Function of Evolving Systems will be held in Waterville Valley, New Hampshire. Apply today to reserve your spot.

Alison Feder reposted

Genuine question for folx who look at bacterial phylogenies: How do you interpret the bootstrap support and posterior probabilities that you get on your tree estimates? Do you take them seriously? Do you think: "Wow, all 99%, that must be a reliable tree!"? 1/

Alison Feder reposted

Alison Feder reposted

What if an embryo made immune cells before it finished building the tissue they usually come from? In our new preprint, we show that annual killifish embryos specify neutrophils before germ layers are fully resolved. www.biorxiv.org/content/10.6... Huge thanks to my PI, @ohnolog.bsky.social ! 🧵

biorxiv.orgEarly immune cell development precedes gastrulation in annual killifishDuring embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

Alison Feder reposted

Alison Feder reposted

Two pleas from a journal editor: 1. If you're mid-career or senior and are declining a review, please recommend a junior colleague. 2. If you're early-career and want to be asked to review papers, please ensure editors can readily discover your expertise, current affililation, and email address.

Excited that Elena Romero is speaking about HIV intra-host evolution in the Crow Award session today at #PEQG26! Her talk focuses on her recent paper (www.pnas.org/doi/10.1073/...) and unpublished follow up work asking what diversity and linkage signatures look like for "ultra-soft" sweeps!

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...