Jyot Antani

Jyot Antani

@antanij.bsky.social

https://antanij.github.io/ Microscopy of bacteria and their viruses. Scientist @yale.edu @paulturnerlab.bsky.social. Phage researcher, biotech enthusiast. Research Facilitator @omibs-mbl.bsky.social

1.2K followers818 following61 posts

Jyot Antani
@antanij.bsky.social

Yesterday I was on Capitol Hill with fellow members of @asm.org. We met with members of Congress and their staff to emphasize the need for robust federal science funding & to urge withdrawal of the OMB proposed rule on federal financial assistance. #ASMAdvocacy #Science #PublicHealth #SciencePolicy

Jyot Antani reposted

Noah Houpt
@noahhoupt.bsky.social

Thrilled to see this project officially published in ISMEJ! We showed that filamentous prophages frequently acquired repressor mutations causing hyperactivity which, in turn, drove the evolution of phage resistance with pleiotropic consequences. academic.oup.com/ismej/advanc...

academic.oup.comMutations in filamentous bacteriophages spark eco-evolutionary feedbacks in Pseudomonas aeruginosaAbstract. Microbial populations strongly shape their environment, which can re-route adaptation toward organism-generated fitness optima. However, the cond
Noah Houpt@noahhoupt.bsky.social

Interested in eco-evolutionary feedbacks? Microbial experimental evolution? Pleiotropy? Filamentous phages?? Check out our latest preprint, now up on BioRxiv! biorxiv.org/content/10.6... For a quick summary, peep the thread below...🧵 (1/10)

biorxiv.orgbiorxiv.org
Jyot Antani
@antanij.bsky.social

The preprint was already exciting but this awesome single-virus paper from @joshuasweitz.bsky.social lab is now published in a great journal! phys.org/news/2026-07...

phys.orgScientists find hidden individuality in viral infectionsAn international team of researchers developed a new way to uncover hidden differences in how viruses infect and destroy individual microbial cells—solving a biological puzzle that has persisted for m...
Joshua Weitz@joshuasweitz.bsky.social

Bacteriophage continue to have so much to teach us. It's in our interest to understand how they work and impact human & environmental health. New joint work led by @mariandm.bsky.social & @rantahan.bsky.social inferring single-cell latent period & burst size heterogeneity from population dynamics.

science.orgInferring single-cell heterogeneity of bacteriophage lysis-associated life-history traits from population-scale dynamicsTheory-guided experiments reveal single-cell heterogeneity of lysis-associated bacteriophage traits from population scale data.

Jyot Antani reposted

Vivek Mutalik
@vivekmutalik.bsky.social

📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.

Jyot Antani reposted

PLOS Biology
@plosbiology.org

How do #bacteriophage life history strategies influence host invasion & inter- #phage competition in #biofilms? This study shows that spatial structure shapes invasion success, favoring temperate phages over lytic ones when diffusion is limited @plosbiology.org 🧪 plos.io/47Aripq

Jyot Antani
@antanij.bsky.social

@paulturnerlab.bsky.social and I wrote a perspective on the need and recently developed approaches to study individual virus traits in the most numerous viruses on our planet (phages). Let's move beyond measuring the mean #phagesky www.nature.com/articles/s44... #microsky #virology #microscopy

nature.comRage against the mean: a perspective on measuring fitness of individual phage particles - npj Virusesnpj Viruses - Rage against the mean: a perspective on measuring fitness of individual phage particles

Jyot Antani reposted

Vivek Mutalik
@vivekmutalik.bsky.social

New paper 🔔 Collaboration @sullivan-lab.bsky.social Marissa Gittrich led the work Klebsiella phage biology has focused almost entirely on capsulated strains, but capsule loss is the #1 resistance mechanism under phage predation. We used a naturally acapsular host to reveal the receptor landscape

Jyot Antani
@antanij.bsky.social

Who runs the world? PHAGE!! Phage dynamics underlie bacterial reaponses to temperatures in a marine bacterium #phagesky #microsky

Cathy Hernandez@cathyhernandez.bsky.social

Excited to share a preprint of work from my postdoc with @paulturnerlab.bsky.social exploring how prophages can impact host thermal ecology and evolution. www.biorxiv.org/content/10.6...

biorxiv.orgbiorxiv.org

Jyot Antani reposted

Simon Roux
@simrouxvirus.bsky.social

🦠🧪🧬🚨 New paper and database alert: the new IMG/VR release is now MetaVR ! We have a new website - meta-virome.org - with quick search capabilities for the >24M viruses, >12M vOTUs, and >42M protein clusters (including >790k with predicted structures !). academic.oup.com/nar/advance-...

academic.oup.comMeta-virus resource (MetaVR): expanding the frontiers of viral diversity with 24 million uncultivated virus genomesAbstract. Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is st
Jyot Antani
@antanij.bsky.social

Congratulations Nanami! Glad to see this work published!

Nanami Kubota@nanamikubota.bsky.social

Published in Current Biology! P. aeruginosa can use its filamentous phage to inhibit competitors but high phage production is susceptible to cheater miniphage invasion. Subsequent phage tragedy of the commons can lower bacteria and phage fitness. Link: authors.elsevier.com/c/1lt5I3QW8S...

Jyot Antani
@antanij.bsky.social

Yay Cathy!!!

Cathy Hernandez@cathyhernandez.bsky.social

Very happy to share that I will be starting as an Assistant Professor in the department of Biological Sciences at the University of South Carolina in January! My group will be working on environmental phage ecology and evolution, and I am recruiting for the upcoming year (more info below).

Jyot Antani reposted

Mike Blazanin
@mikeblazanin.bsky.social

Happy to see this paper finally out in @pnas.org! #phage #microbiology #MicroSky #VirEvol 🦠 🧫 🔬 Gift link: www.pnas.org/eprint/YYDZ9...

pnas.orgQuantifying phage infectivity from characteristics of bacterial population dynamics | PNASA frequent goal of phage biology is to quantify how well a phage kills a population of host bacteria. Unfortunately, traditional methods to quantif...
Mike Blazanin@mikeblazanin.bsky.social

Excited to see this new, and extensively-rewritten, version of our preprint up now! With @paulturnerlab.bsky.social we show how bacterial population dynamics (e.g. growth curves) can be used to accurately quantify bacteriophage infectivity 🦠 🧫🔬 #microbiology #VirEvol doi.org/10.1101/2023...

doi.orgQuantifying phage infectivity from characteristics of bacterial population dynamicsA frequent goal of phage biology is to quantify how well a phage kills a population of host bacteria. Unfortunately, traditional methods to quantify phage success can be time-consuming, limiting the t...

Jyot Antani reposted

Noah Houpt
@noahhoupt.bsky.social

Come check out my poster tomorrow at #ASMicrobe in the E&EB section! We found that repressor mutations in Pf prophages sparked a coevolutionary dynamic that resulted in loss of twitch motility and susceptibility to virulent pilus-targeting phage. Would love to chat about all things phage :).

Paul Turner Lab@paulturnerlab.bsky.social

Turner Lab representation at #ASMicrobe #ASMicrobe2025 (3/5) Grad student @noahhoupt.bsky.social will present the story of experimentally evolving a Pseudomonas lab strain for 150 generations over 1000 days. Spoiler alerts: #prophages are important! 🦠📊 #evolution

Jyot Antani reposted

Cathy Hernandez
@cathyhernandez.bsky.social

For #ASMicrobe folks - looking forward to a busy phage day on Sunday!

Paul Turner Lab@paulturnerlab.bsky.social

Turner Lab representation at #ASMicrobe #ASMicrobe2025 (4/5) Current postdoc, soon-to-be-PI @cathyhernandez.bsky.social is presenting a poster on the involvement of prophages in thermal ecology of marine microbes 🌊🦠 She is also convening a session on #prophages and giving a rapid fire talk! 🔥

Jyot Antani
@antanij.bsky.social

Come to my poster 🔬🦠 #ASMicrobe #ASMicrobe2025 #phage #phagesky

Paul Turner Lab@paulturnerlab.bsky.social

Turner Lab representation at #ASMicrobe #ASMicrobe2025 (5/5) Associate Research Scientist @antanij.bsky.social is telling a story about multidimensional measurements (including high-throughput adsorption assays) of phage-bacteria interactions #microscopy 🔬

Jyot Antani
@antanij.bsky.social

(2/3) key strengths for me: * click on a reference (e.g., number or FirstAuthor Year) and it brings up the full detail (title, authors, year, google scholar link) without going to ref section * click on figure reference, brings you to figure. click back button, brings you back

Jyot Antani
@antanij.bsky.social

(3/3) * night mode (also relevant beside just reading if you make your presentations in black background - you can snip the figures in dark mode and paste into your presentation, which looks more professional than pasting a white-background figure)

Jyot Antani
@antanij.bsky.social

Latest paper drop from Yale Phage Center @paulturnerlab.bsky.social

INCATE@incate.bsky.social

Yale researchers have made a breakthrough in fighting drug-resistant infections in cystic fibrosis with inhaled bacteriophage therapy - offering new hope against antimicrobial resistance. 🔗 www.nature.com/articles/s41...

nature.comPersonalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis - Nature MedicineA novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of antimicrobial-resistant bacteria...
Jyot Antani
@antanij.bsky.social

Very cool thread!

Zach LaTurner@micronaut.bsky.social

Very excited to share a manuscript at the heart of my PhD! We added an RNA-memory device (RAM) to phage P1 to identify transduction hosts in synthetic and wastewater microbial communities in high throughput. Also, I am on the post-doc market, so please reach out if interested! 1/6 t.ly/a8k9O

t.lyCross-order detection of bacteriophage transduction in communities using ribosomal RNA barcodingBacteriophages (phages) facilitate gene transfer and microbial evolution in all ecosystems and have applications as tools for engineering microbiomes and as antimicrobials. Historic efforts to map pha...

Jyot Antani reposted

Phage papers
@phagepapers.bsky.social

Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells. DOI: 10.1073/pnas.2410905121 https://pubmed.ncbi.nlm.nih.gov/39700139/

pubmed.ncbi.nlm.nih.govMicroscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells - PubMedPhages, viruses of bacteria, play a pivotal role in Earth's biosphere and hold great promise as therapeutic and diagnostic tools in combating infectious diseases. Attachment of phages to bacterial cells is a crucial initial step of the interaction. The classic assay to quantify the dynamics of phage …

Jyot Antani reposted

Nanami Kubota
@nanamikubota.bsky.social

Preprint out! Bacteria w/ hyper-replicative filamentous phage lead to overnight emergence of cheater phages. Bacteria w/ both phages can outcompete wildtype, then rapidly lose phage via a phage Tragedy of the Commons @shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...

biorxiv.orgFilamentous cheater phages drive bacterial and phage populations to lower fitnessMany bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...
Jyot Antani
@antanij.bsky.social

YaleNews @yale.edu covered our recent paper on measuring virus attachment 🦠🔬🤩 @paulturnerlab.bsky.social @emonetlab.bsky.social news.yale.edu/2025/04/15/n... #MicroSky #PhageSky #Microscopy #Fluorescence

news.yale.eduNew tool offers insights into virus-cell interactionsA method developed by Yale scientists helps reveal how antibacterial agents interact with their host cells — a process that could boost a host of applications that benefit society.