Taco subo

Taco subo

@averagedoc.bsky.social

Ordinary cardiologist. Extraordinary prior auth filler outer.

207 followers409 following980 posts

If I had to pick, I think I’d go for a bleed rather than an infarct, not reassuring that death was 3x higher in monotherapy group

NEJM.org@nejm.org

In patients at high risk for ischemic events 12 months after implantation of a drug-eluting stent, clopidogrel monotherapy was noninferior to extended dual antiplatelet therapy for net adverse clinical events. Full A-CLOSE trial results: https://nej.md/4ggbFqv #ESCCongress

Guess this explains why the abc score guided trial didn’t work. Doac for everyone!

NEJM.org@nejm.org

In patients with atrial fibrillation and intermediate stroke risk, direct oral anticoagulation led to a lower risk of stroke, systemic embolism, major bleeding, or death from cardiovascular causes than no anticoagulation. Full SINGLE-AF trial results: https://nej.md/4ii61XB #ESCCongress

What’s the rule on systematic reviews in a LLM world? Are we still publishing keywords searched and pretending that we looked through 11000 citations to come up with 5 to include in a meta analysis or can we just ask claude to do it and take 5 seconds? #medsky #cardiosky

Fuck it, let’s just google

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social

As you may have seen - Open Evidence and UpToDate expert AI (specialized in medicine) lose to GPT/Claude/Gemini = generalized models www.nature.com/articles/s41... Why does #Roon think they will be special when they eventually sell MD discussions into an LLM package? 🤔 #MedSky

Anyone else hear arguments from docs against glp1as because lack of long term data? What is this future black box post marketing boogeyman? When has a drug ever had a positive cvot and then come back later with cancer concerns or something ? #medsky

It’s not about the significance of the results that matter for nejm, it’s about how many patients got randomized. Want to test for a difference between 81 mg aspirin and 100 mg aspirin ? Who cares about the result, as long as you had n of 10000 nejm will Publish

NEJM.org@nejm.org

Our latest video in our partnership with @glaucomflecken.bsky.social summarizes the Ez-PAVE trial that evaluated the appropriate LDL cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease. Read the full study for free: https://nej.md/DrG41 #Cardiology

So apparently Wegovy is gonna be $50 for all Medicare beneficiaries starting July 1. How long before the senior citizen black market opens up shop? #medsky

A Kerendia drug rep started talking to me about the spirit-hf results today and it occurred to me that an evil pharma company should just fund a very bad, inconclusive trial for their competitor and use those null results to market how great their drug is by comparison. Medicine is great! #cardiosky

So trump is Muslim now? Can’t beat em…

Chris Murphy@chrismurphyct.bsky.social

If I were in Trump's Cabinet, I would spend Easter calling constitutional lawyers about the 25th Amendment. This is completely, utterly unhinged. He's already killed thousands. He's going to kill thousands more.

Saw an inpatient today with dementia, they gave her one of these dolls to keep her busy. I walk and she says: “WHO’S BABY IS THIS?! WHERES HER MOTHER?!” #cardiosky #medsky

I guess the problem with sentinel wasn’t that it wasn’t a good enough filter. Just that filtering doesn’t matter for stroke. Still plausible that there’s a future cognitive risk from dumping all that valve junk into the circulation #cardiosky

American College of Cardiology@accintouch.bsky.social

PROTECT H2H: Emboliner vs. Sentinel Embolic Protection Devices in #TAVR Explore the findings from the trial unveiled during a Late-Breaking Clinical Trial session at #ACC26: https://bit.ly/4sFQK5r #CardioSky

It’s not all disappointing news for hfpef today. Doubt this can be as crazy effective as with pah but I’d bet a phase 3 for hfpef will be positive #cardiosky

American College of Cardiology@accintouch.bsky.social

#ACC26 CADENCE: Sotatercept, an activin signaling inhibitor, was associated with significant improvements in BP and vascular health in patients with #HFpEF and severe combined post and precapillary pulmonary hypertension (CpcPH). Find out more: bit.ly/4lVI0FL #CardioSky

I threw this and closure into a meta analysis with the old stuff to see the effect on strokes, not too non-inferior. I feel you gotta tell patients : your stroke risk may go up a bit, you’ll have less bleeding down the road but pay the price with bleeds up front. Want one or no? #cardiosky

American College of Cardiology@accintouch.bsky.social

#ACC26: 🆕 Insights from the CHAMPION-AF trial Device-based LAA closure was comparable to NOAC therapy in reducing the combined rate of death from CV causes, stroke, or systemic embolism at 3️⃣ years in pts w/ #AFib who were candidates for #cvCoag. More: https://bit.ly/4bIv5SA #CardioSky #MedSky