Reed Stubbendieck

Excited to announce our new paper in Nature Microbiology describing diphtheria toxin homologues in Streptomyces called Streptomyces antiquus insecticidal proteins (SAIP), stemming from a long term collaboration with Ying Xu, Min Dong, Cameron Currie, and many others. www.nature.com/articles/s41...

Has anyone had recent contact with NCBI regarding genome submissions? I've got some that I want released for an accepted paper, but have had zero luck getting a response to requests for immediate release.

COMMBAT: a web platform for exploring expression control of biosynthetic gene clusters @narjournal.bsky.social from @sebarigali.bsky.social With @gillesvanwezel.bsky.social @marnixmedema.bsky.social academic.oup.com/nar/advance-...

Research into filamentous actinomycetes, the antibiotic producers, is in steep decline. Loads of natural products chemistry research worldwide but not much aimed at understanding their biology and ecology. The latter is key to unlocking their specialised metabolism link.springer.com/article/10.1...

On International Day of Women and Girls in Science 🔬👩‍🔬 We’re launching the Women Microbiologists Network: a member-led networking and discussions event for women in microbiology by Dr. Enas Newire. Read the news story and join: 🔗 https://microb.io/4ax5M5I

My lab has published our first paper! We previously showed that Rothia are associated with healthy nasal microbiomes and inhibit the pathobiont Moraxella catarrhalis. We now describe the novel species Rothia similimucilaginosa. Check it out here: www.microbiologyresearch.org/content/jour...

I’m excited to share the first paper from my lab that was led largely by undergraduate students at University of Wisconsin and Washington College! #secmet #natprod www.frontiersin.org/journals/mic...

Semester ended with two manuscripts accepted after over a year each in review! Happy Holidays all!

#secmet

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces www.gla.ac.uk/postgraduate... please repost

The first paper from PhD student Niladri Bhowmik is out today as a PLOS Pathogens Pearl: Achromobacter spp.: Emerging pathogens in the cystic fibrosis lung. Congrats Niladri! journals.plos.org/plospathogen...

Recorded #MattersMicrobial Episode 88 with Dr. Reed Stubbendieck from Oklahoma State today. Great conversation about how microbes converse with one another during sickness and health. Fascinating! @bactereedia.bsky.social

We have been dealing with high background using erythromycin selection for multiple E. coli strains in my lab. We've tried multiple vendors and lots, but the problem persists. Has anyone else had this problem before? Any ideas?

#NewPI life

My lab’s first preprint! We used functional metagenomics to identify phage defenses in human and soil microbiomes. We scaled these selections while maintaining accuracy, enabling us to examine 9 habitats for defense elements against 7 phages. www.biorxiv.org/content/10.1... 1/10

"downsizes" is a weak way of saying "forced to cancel dozens of programs, which jeopardizes future STEM careers of talented undergrads" @science.org www.science.org/content/arti...

Some of my first year grad students in my class are asking for books to read that will get them thinking about what questions to ask and how to know what they should ask. I have a couple of recs but wondering if anyone can help. What inspired you??

GATOR-GC preprint is live! If you haven't already, check out our new tool for targeted gene cluster mining. @jcedielbecerra.bsky.social doi.org/10.1101/2025...

We are crowd sourcing reductions in graduate admissions and hiring freezes across biomedical research and higher ed in response to pauses in NIH funding and EO’s. If you have information if you could add to this spreadsheet, it would be greatly appreciated!: docs.google.com/spreadsheets...

Just sitting here, trying to write a grant, crying for so many thousands who dedicated their lives to making the world better and safer, just thrown out like trash today.

"Make America Great Again. Make America Healthy Again. These were promises made by candidate Trump in his campaign to be president of the United States of America. What in this campaign platform should have prepared us for a war on discovery?"

Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

~5y ago, Barbara, Serina, @marnixmedema.bsky.social & I teamed up to make a better NRPS A-domain specificity predictor. The Challis group & others joined along the way to add some very cool insights. Very proud of this work. Check it out now on biorxiv! doi.org/10.1101/2025...

www.biorxiv.org/content/10.1... #secmet 🧪🖥️🧬

My current state is exemplifed by the duck of ennui.

Just in time for the holidays Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin www.biorxiv.org/content/10.1... @amerrild.bsky.social @tizianasvenningsen.bsky.social @thomastorring.bsky.social

Interesting tool alert. The thing that makes this look promising is a way to "plasmidify" biosynthetic gene clusters in their native producers. Could simplify refactoring and expression in chassis strains. #secmet www.science.org/doi/10.1126/...

Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...

Completed my reappointment talk yesterday! It was nice to reflect on two years of progress in the laboratory. I am so fortunate to get to work with this excellent team of scientists!

Just submitted the first manuscript from our lab! Wish us luck!

Does anyone know of any opportunities for funding #natprod postdocs that non-US citizens are eligible for?

This is my revolutionary new idea to obtain funding for the laboratory.

Is anyone else having problems logging into NCBI right now? Trying to update a bibliography for a submission.

Looks like there was another Twitter exodus, and I'm seeing new followers. If you're interested, I have a Starter Pack of Bluesky secondary metabolism and chemistry-related folks. Let me know if you belong in there! Please share widely! go.bsky.app/Q9svkYf

Working on an analysis using published data in the SRA, but missing metadata is an issue. About half of the authors I've contacted shared it upon request, the rest haven’t responded despite follow-ups. Debating whether to keep asking, contact journals, or move on. Any advice?