Drop your pipettes; we have an exciting meeting for you
**The Spatial Logic of RNA in Health and Disease**
When: 20.11.2026
Venue : Goethe University Frankfurt, Niederrad Campus, Haus 22, H22-1
Participation is free, but registration is required.
Registration
bit.ly/4gaXOBL
🫶Spread the word
Do you want to start your PhD at the Cologne Graduate School of Ageing Research in 2027?
🗓️ Don't miss our deadline: November 3, 2026.
To help you get started with your application, our wonderful PhD students and faculty members have some tips for you in our short video. Enjoy! 🍿
🚀 Applications now open for the CECAD Postdoc Academy for Aging Trajectories!
We are thrilled to share the first call for applications for our new CECAD Postdoc Academy for Aging Trajectories. Find all information here: uni.koeln/GJPU8
🔬Researchers @beyerlab.bsky.social@cecad.bsky.social developed a method that enables damage to individual cells to be precisely quantified. It uses molecular markers and enables the detailed analysis of disease progression in individual tissue samples, such as a biopsy ➡️ uni.koeln/W5DU7
Paper out on single-cell damage scores.📜Quantify the damage of single podocytes or hepatocytes using their transcriptomes to study degenerative diseases. Big congrats to the Beyer-Lab members Tim Padvitski and Paula Unger 🍾🌟🎉 Thanks to all the fantastic collaborators!
www.cell.com/cell-genomic...
Our paper on mutation susceptibility along the human genome is out! 📜🎉Big congrats to Corinna Schmalohr, Yashna Paul and Nina Bundschuh from the Beyer-lab 🌟🍾Susceptibility for mutations is remarkably similar across tissues #CRC1310#CRC1678link.springer.com/article/10.1...
🚨 Publication Alert 🚨
New study from #CRC1678 members @beyerlab.bsky.social and @muellerrom.bsky.social maps kidney and liver disease using cell‑type‑specific damage scores. PDS/HDS track cell injury and reveal circadian disruption and a MASLD/NASH threshold. 🍾🥳
👉 www.cell.com/cell-genomic...
We are excited to announce the #CRC1678 Summer Symposium!
🗓️ June 22, 2026
📍 Auditorium, MPI for Biology of Ageing, Cologne
A student‑organized day of scientific exchange featuring CRC researchers and international invited speakers.
🔗 More information on our event website: uni.koeln/U7FHR
SPACO, our tool for Spatial Component Analysis for Spatial Sequencing Data, is now available as R package on CRAN!🎉 Congratulations to the team!!! We also have a Docker image which is available on Zenodo. #SpatialTranscriptomics #DimensionalityReduction
📣#CECAD will host two exciting conferences
📆 11th - 14th October 2026 15th AHA Conference - “From mechanisms of age-associated diseases to healthy aging” uni.koeln/7X2K8
📆 14th - 16th October 2026 1stEFAR Conference - “On the Biology of Aging” uni.koeln/YGPMA
👉 Submit abstracts by May 31st
🚨 Speaker Alert! 🚨
We’re excited to welcome Christina Leslie to our upcoming #CRC1678 Seminar.
🧬AI models for regulatory genomics and spatial biology
📅 March 17
📍Auditorium, MPI-Age
⏰ 3:00 PM
Join us to explore cutting‑edge AI models shaping regulatory genomics and spatial biology!
Big congratulations to our #CRC1678 partner Niels Gehring! Isn't it amazing how little we understand about the molecular mechanisms of something as important as NMD?
Read this:
www.nature.com/articles/s41...
🔬🧬Detecting and destroying defective RNA: that's what nonsense-mediated mRNA decay does
Researchers #UniCologne have now identified the central mechanism of the control system. The two proteins—SMG5 and SMG6—together form a molecular “scissor” that cuts up the defective mRNA▶️ uni.koeln/HGW4Y
Thanks to @antebilab.bsky.social for involving us in this project! Beyer-lab member Francisco Lopes helped with the data analysis and came up with a cool way to study the stoichiometry control of ribosomal proteins. Read the preprint for more!
1/4 Our preprint “Modulation of the RNase P/MRP complex and mitochondrial ribosome enhances cytosolic ribosome coordination and sustains longevity” is now live @biorxivpreprint.bsky.social 📄 #agingbiology#ribosome 👉https://www.biorxiv.org/content/10.64898/2026.02.23.707525v1
🚨Publication Alert🚨
New work from our #CRC1678 members Niels Gehring and @volkerboehm.bsky.social published in @natcomms.nature.com shows that SMG5 & SMG6 PIN domains form a composite endonuclease (cPIN)
enabling efficient mRNA cleavage🧬
How are faulty #RNA degraded?
New mechanistic insight into NMD:
1️⃣SMG5 & SMG6 PIN domains form a composite endonuclease (cPIN)
2️⃣ SMG5 completes the SMG6 active site, enabling efficient mRNA cleavage
Fantastic collaboration with @labconti.bsky.social 🙏
👉 www.nature.com/articles/s41...
1/n
PKD International warmly congratulates @muellerrom.bsky.social on this important new step. We are deeply grateful for his unwavering commitment to patient advocacy and for his continuous efforts to advance the interests of the PKD community.
🧬🧬🧬 REGISTRATION JUST OPENED! Make sure you join our DNA REPAIR MEETING 2026 ON PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY in Cologne, September 7-9, organized by the German Society for DNA Repair (DGDR) and the @dfg.de Research Unit 5504. www.for-5504.com/en/197/Confe...
📢 PhD Positions - CALL FOR APPLICATIONS - 26/01 (m/f/d)
The Leibniz Graduate School on Aging (LGSA) is a joint program of the @leibnizfli.bsky.social and the @uni-jena.de (FSU) in #Jena. The School calls for #applications for #PhD positions. 👇
➡️ More: jobs.leibniz-fli.de/jobposting/c...
Beyer Group proudly presents: "Snow White and the Data Miners". It's so much fun to be part of Cologne Carnival!
Thanks to all the costume designers and makers, especially to Paula and Jakub!!!
We are VERY much looking forward to the selection week and meeting the candidates! All of them are very smart people and we will have many inspiring discussions.
🎓
🌏 CGA Recruitment Week is just around the corner, and we’re looking forward to meeting the top 25 applicants from all over the world! But what actually happens during CGA Recruitment Week? And what other activities can our students enjoy once they’re part of the CGA? Find out more! 🎬
To celebrate today’s International Day of Women and Girls in Science, we are spotlighting inspiring young female researchers from our #CRC1678, sharing their stories, motivations, and hopes to encourage the next generation to pursue science. 🧪🔬👩🔬 #WomenInScience#GirlsInSTEM
👩🔬 Today is International Day of Women and Girls in Science! Meet Nisha Hemandhar Kumar @nishahemandhar.bsky.social, postdoctoral researcher in the group of @beyerlab.bsky.social at the @unicologne.bsky.social
🚨 Publication alert 🚨
Check out this brand new review article about Proteostasis of organelles in aging and disease in @febsj.bsky.social. Congratulations to our #CRC1678 members @thevilchezlab.bsky.social and Yara Nabawi and everyone else involved🎉
Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal!
We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease
doi.org/10.1111/febs...
🚨Publication Alert🚨
New work from our #CRC1678 members @bjornschumacher.bsky.social and @meyerdh.bsky.social reveals why some neurons age faster. Using neuron‑specific aging clocks, they identified vulnerable neurons and highlight syringic acid and vanoxerine as promising neuroprotective hits.🧬
Why do some neuron types degenerate early while others stay intact?
We used transcriptomic aging clocks for single-neuron-types in C. elegans and found neuron-specific biological age predicts vulnerability.
🧪
www.nature.com/articles/s43...#Neurodegeneration 🧵👇 (1/n)
🚨 New @cp-cell.bsky.social paper with #CRC1678 member Domenico Di Fraia form @beyerlab.bsky.social ! 🚨
In this study published in Cell, a brain‑cell lysosome atlas reveals SLC45A1 as a neuron‑specific transporter linked to LSDs. Congratulations! 🎉
🔗 doi.org/10.1016/j.cell.2025.12.012
🚨Hot off the press from #CRC1678 's @ignatovalab.bsky.social 🚨
A brand‑new paper published in @narjournal.bsky.social introduces ADAM‑tRNA‑seq, a powerful framework that finally brings accuracy and scalability to Nanopore‑based direct tRNA sequencing. Congratulations! 🥳
Interested in direct tRNA-seq by Nanopore? We developed a new RNA-based barcoding aproach for seq parallelization; it is also cost-saving. Scripts available on github. #tRNA#Nanoporetrack.smtpsendmail.com/9032119/c?p=...
🚨 Speaker Alert! 🚨
We’re thrilled to welcome Duygu Ucar for an upcoming joint #CRC1678 / #CECAD Seminar about “Heterogeneity in Human Immune Aging and Vaccine Responses”.
📅 February 4
📍 CECAD Lecture Hall
⏰ 2:30 PM
Join us for fresh insights into the complexity of human immune aging!
One of the greatest computational biologists of Germany - of the world I should say. He majorly shaped the field, never got stuck in one corner of science, but kept exploring new areas due to his curiosity, always aimed to understand the biology, and trained generations of scientists.
I’ve changed my header photo to this one. It shows my father Herbert and his sister Lotte with their parents Fritz and Marta in their Frankfurt apartment before Herbert and Lotte were sent to England on the Kindertransport, and later Fritz and Marta transported to Lodz Ghetto, final fate unknown.
We’re delighted to report a global structural proteome analysis within living cells!
doi.org/10.1038/s443...#proteomics#structuralproteomics#massspectrometry#structuralbiology#ethz@imsb-eth.bsky.social
We’re delighted to report a global structural proteome analysis within living cells!
doi.org/10.1038/s443...#proteomics#structuralproteomics#massspectrometry#structuralbiology#ethz@imsb-eth.bsky.social
Three #CRC1678 PhD students joined Lena Breuer’s ImproKoeln workshop 🎤 last week, learning improvisation, camera presence & interview skills. They’re now ready to spotlight diverse scientific journeys in our upcoming #DiversityInScience video campaign!
BatProtect - 3 day programme kicked off by @bjornschumacher.bsky.social followed by keynote from #StevenAustad on Methuselah's Zoo: what nature can teach us about living longer, healthier lives
Congratulations! 👏
Dennis de Bakker from @leibnizfli.bsky.social received the LIFE Talent Award 2025 at the “4th LIFE Symposium – Time to connect”, which took place on November 26, 2025, in #Jena.
Photos: Anna Schroll
With @uni-jena.de
🚀 New on the #CRC1678 Website! 🌐
Explore Job Opportunities + Fellowships:
- Postdoc Position🔬
- Medical Research Fellowship (6 months)👩⚕️
- PhD Orientation Fellowship(4 months)🎓
📅 Open year-round, no deadline, open to all!
👉 crc1678.uni-koeln.de/job-opportun...
🔥🔥🔥Now out in print: how do germ cells instruct the soma and how does the soma impact inheritance? Together with Shoma Ishikawa we provide a comprehensive overview of The Somatic Impact on Inheritance and the Germline Control of the Soma - www.annualreviews.org/content/jour...
🚨 Postdoc Opportunity within the #CRC1678 - @riemerlab.bsky.social
🔬 Study redox regulation & proteome plasticity via translation initiation
📅 Start: March 2026 (or later)
💼 100% E13 funded
👉 Apply now to explore molecular mechanisms in mammalian cells: crc1678.uni-koeln.de/job-opportun...
We had a fantastic time at the Ribo-Seq workshop in Bonn. Thanks so much, Kathrin @katleppek.bsky.social and Ranen, for organizing! We learned a lot, and we're excited to use Ribo-Seq in future projects.
We are well into our 5-day Cluster Workshop on Ribosome Profiling (Ribo-seq) run by sabbatical scientist Ranen Aviner @czbiohub.bsky.social. We welcome PhDs and PIs from Bonn/Cologne for a hands-on and analysis course sponsored by the Cluster @immunosens.bsky.social@unibonn.bsky.social UKB.
Hello #rstats! 👋 Do you have an #rstats package or skill or strategy you love and would be willing to share with the @rladies.org community? We are looking 👀 for a couple more speakers 🔊 for the 2025–2026 R-Ladies St. Louis season. Reply here and we will contact you to find a date! 💜 💜 💜
Nice work together with the @jaelab.bsky.social on Fam136A as a novel Disulfide Relay substrate and guardian of proteostasis in the mitochondrial IMS - www.sciencedirect.com/science/arti.... Accompanied by a small graphical abstract…
Last Friday, we had an inspiring 10th Rhineland RNA Club meeting with top class speakers. It's great to see how the community is growing and the range of topics we're covering. Special thanks to Didier Stainier @stainierlab.bsky.social Simon Bekker-Jensen @bekkerjensenlab.bsky.social, Ranen Aviner!