Announcing the website for the song Ring That Bell 🔔 cowritten w @magsmccarthy.bsky.social an emotional story of a cancer patient facing relapse and the fierce advocacy, support, and groundbreaking science that offer new hope. #cancer#cancerresearch#immunotherapy#hoperingthatbellsong.com
Heading to the @isctglobal.bsky.social l Annual Meeting in Dublin? Come visit us at the Penn Medicine Clinical Cell and Vaccine Production booth 2505 1st Floor The Liffey across from ISCT Hub and meet our Facilities, Analytics, Operations, Regulatory and Manufacturing Experts.
We are actively looking to partner with biotech, pharma, and academic groups
If you are advancing a program and need a partner who understands both the science and the realities of clinical translation, we should connect www.med.upenn.edu/cvpf/
We’ve built an integrated platform designed to move programs from discovery into first-in-human studies with rigor, speed, and quality.
What differentiates this model is not a single capability, but the integration:
• Manufacturing
• Process development
• QC analytics and correlative science
Heading to the @isctglobal.bsky.social l Annual Meeting in Dublin? Come visit us at the Penn Medicine Clinical Cell and Vaccine Production booth 2505 1st Floor The Liffey across from ISCT Hub and meet our Facilities, Analytics, Operations, Regulatory and Manufacturing Experts.
Heading to the @isctglobal.bsky.social l Annual Meeting in Dublin? Come visit us at the Penn Medicine Clinical Cell and Vaccine Production booth 2505 1st Floor The Liffey across from ISCT Hub and meet our Facilities, Analytics, Operations, Regulatory and Manufacturing Experts.
We’ve built an integrated platform designed to move programs from discovery into first-in-human studies with rigor, speed, and quality.
What differentiates this model is not a single capability, but the integration:
• Manufacturing
• Process development
• QC analytics and correlative science
We are actively looking to partner with biotech, pharma, and academic groups
If you are advancing a program and need a partner who understands both the science and the realities of clinical translation, we should connect www.med.upenn.edu/cvpf/
NEW - Data-informed optimization of CAR T-cell therapy long-term follow-up
At >60K patients treated, CAR-T LTFU is due for a reset. AEs are infrequently reported >3 years post-infusion, so 5 years is more appropriate considering low risk, cost burden, burdens on patients jitc.bmj.com/content/14/4...
15 year LTFU burdens on patients include:
-Frequent visits, testing, requirements
-Travel burden and costs, often tied to specialized treating centers
-Ongoing disruption to work, family life, and daily routines
-Psychological burden of prolonged monitoring with diminishing clinical yield
🚨NEW FDA Draft Guidance Safety Assessment of Genome Editing in Human Gene Therapy Products Using Next-Generation Sequencing #FDA#Regulatory#geneediting#genetherapy
Top 5 Takeaways in reply
www.fda.gov/regulatory-i...
Top 5 #FDA Takeways
1) NGS now the regulatory backbone for genome editing safety
2) FDA wants layered approach to off-target assessment
3) Low-frequency events matter, must be detectable
4) Patient genetics now part of risk assessment
5) Genome integrity no longer optional for DSB-based gene editors
What the peptide craze reveals about Americans’ relationship with risk. Great piece from @sarah-todd.bsky.socialwww.statnews.com/2026/04/06/r... It's so odd how many people will not trust proven biomedical approaches but embrace and literally shoot up with unproven things like peptides
Announcing the website for the song Ring That Bell 🔔 cowritten w @magsmccarthy.bsky.social an emotional story of a cancer patient facing relapse and the fierce advocacy, support, and groundbreaking science that offer new hope. #cancer#cancerresearch#immunotherapy#hoperingthatbellsong.com
NEW - Public Service Announcements linked to Ring That Bell to run on radio stations across the USA are designed to raise awareness about the song and its connection to cancer advocacy. We aim to inspire action and support for cancer initiatives. Listen at RingThatBellSong.com below music video
🚨Congratulations to Prof. Dr. Carl June & Prof. Dr. Michel Sadelain! 2025 laureates of the Broermann Medical Innovation Award for the development of the CAR-T cell #immunotherapy#cancer#CancerResearchpressreleasehub.pa.media/article/dr-c...
Announcing the website for the song Ring That Bell 🔔 cowritten w @magsmccarthy.bsky.social an emotional story of a cancer patient facing relapse and the fierce advocacy, support, and groundbreaking science that offer new hope. #cancer#cancerresearch#immunotherapy#hoperingthatbellsong.com
My CNBC.com segment on implications for pediatric vaccine schedule from recent politics. 2003 saw ~5,000 cases of pertusis, in 2024 there were over 35,000, and for 2025, some models show 70,000+
We risk a return of communicable diseases in children.
www.youtube.com/watch?v=00cI...
🚨Just published - Multiplex engineering using microRNA-mediated gene silencing in CAR T cells #celltherapy#genetherapy#immunotherapywww.frontiersin.org/journals/imm...
🚨Coming soon! Multiplex engineering using microRNA-mediated gene silencing in CAR T cells. In a single lentiviral vector- multiplex silencing & expression of a CAR, better expansion & viability than gene editing by electroporation www.frontiersin.org/journals/imm...
My new 2-minute 5-point short on why one shouldn't go to stem cell clinics or at least seriously weigh risks + low chance of benefit. Good little video for scientists and physicians too looking for clear explanation when people ask #stemcells#stemcellwww.youtube.com/shorts/EX9iU...
Cutting NIH to “save” money is fundamentally flawed
-Modest annual savings pale compared to multi‑trillion‑dollar health, innovation, and productivity losses www.statnews.com/2025/07/28/n...
From Pink Sheet on continued departures from FDA’s biologics division and challenges backfilling openings. FDA biologics center reported 106 departures from Jan. 1 to June 30. These numbers don’t include the 100-150 who were part of the reduction-in-force
insights.citeline.com/pink-sheet/a...
FDA’s cancer review team overseeing breast and gynecological products has lost about 1/3 of its medical review staff and the malignant heme group will lose about 2/3 of its medical review staff—all to voluntary resignations clustered among seasoned reviewers
insights.citeline.com/pink-sheet/a...
CNN pundit Scott Jennings said almost 5 million nondisabled Medicaid recipients “simply choose not to work” and “spend six hours a day socializing and watching television.”
KFF Health News + @politifact.bsky.social rate this statement False. Read why. ⤵️ kffhealthnews.org/news/article...
If gifted narrative filmmaker Marwin Gansauge asks, "Can I make a movie about you?", what do you say? More than ever, science communication is desperately needed to convey the importance of research in developing new treatments for patients. Filmed in Vancouver & Dublin youtu.be/YrevpY-DNmw
Is Makary's FDA already heading toward a breaking point? ipscell.com/2025/07/is-m...#stemcells#stemcell#CRISPR what does it mean for the cell and gene therapy field?
How did the pandemic start?
I have avoided publicly commenting on this for 5 years. Here's my take as someone who has no stake at all in the game.
gidmk.substack.com/p/pandemic-r...
A new large study from Denmark finds no evidence that aluminum salts used in vaccines are tied to a higher risk of childhood diseases.
www.statnews.com/2025/07/14/a...
A well-placed biotech investor says U.S. policies are straining life sciences startups — and more disruption is coming.
www.statnews.com/2025/07/15/b...
🧵1/3 How discoveries become cures, in a virtuous cycle
@pennmedicine.bsky.social
- Public investments in biomedical research have an outsized effect, driving new scientific insights, economic growth, and ultimately treatments and cures. #NIHpennmedicine.org/news/how-dis...
🧵2/3 How future cures begin as ideas in laboratories
The successes of CAR T research show the importance of the cycle of science
@PennMedicine
—sparking new ideas and clinical trials that give patients better options. pennmedicine.org/news/how-fut...
🧵3/3 Academia and industry form powerful partnerships for impact @pennmedicine.bsky.social
Since 2018, the Penn Medicine Co-Investment program has spurred faculty innovation, created jobs, and scaled up ideas into large-scale clinical studies. pennmedicine.org/news/academi...
#Breaking: The United States has now recorded more confirmed measles cases this year than in any year in well over a quarter-century.
www.statnews.com/2025/07/09/m...
After spearheading a 34% cut in cancer mortality, the National Cancer Institute at the NIH is bleeding resources and staff and could see its budget cut by nearly 40%. kffhealthnews.org/news/article...
🚨Worse than you think "World’s premier cancer institute faces crippling cuts and chaos" There used to be bipartisan support. Now:
-Rat on your colleagues
-Silencing the science communicators
-A budget to ‘destroy clinical research’
#NCI#NIH#Cancer#cancerresearchwww.cnn.com/2025/07/08/h...
Bioengineered immunocompetent preclinical trial-on-chip tool enables screening of CAR T cell therapy for leukaemia. #Tcell#immunotherapy#organonachip 🧪https://www.nature.com/articles/s41551-025-01428-2