E John Wherry

E John Wherry

@ejohnwherry.bsky.social

Immunologist. T cell exhaustion, immunotherapy, Immune Health.

2.8K followers356 following67 posts

E John Wherry
@ejohnwherry.bsky.social

What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...

biorxiv.orgDivergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potentialPersistent antigen stimulation promotes differentiation of exhausted CD8+ T (TEX) cells. TEX cells are distinct from circulating memory T (TCIRCM) cells but share many features with tissue-resident me...
E John Wherry
@ejohnwherry.bsky.social

A great Keystone meeting on Long COVID this week in Santa Fe. The field has made great progress recently, but there is much more to do. Exciting science presented about viral and immune mechanisms, clinical data and future clinical trials. www.keystonesymposia.org/conferences/...

keystonesymposia.orgLong COVID and Other Post-Acute Infection Syndromes | Keystone SymposiaJoin us at the Keystone Symposia on Long COVID and Other Post-Acute Infection Syndromes, August 2025, in Santa Fe, with field leaders!

E John Wherry reposted

David J. Skorton
@davidjskorton.bsky.social

I’ve been in academic medicine for 45 years. This is the first time I’m seeing a perfect storm, as proposed federal funding cuts threaten our ability to provide patient care, train the next generation of doctors, and conduct life-saving research. More from my conversation with @cnn.com last week.

E John Wherry reposted

Hensley Lab
@scottehensley.bsky.social

To be clear, these kinds of breakthroughs are going to come to a screeching halt with the current NIH funding cuts. This new treatment is only possible because of decades of basic research. What might be possible 20 years from now if we don't destroy basic research? www.nature.com/articles/d41...

nature.comWorld’s first personalized CRISPR therapy given to baby with genetic diseaseTreatment seems to have been effective, but it is not clear whether such bespoke therapies can be widely applied.

E John Wherry reposted

Gregg Gonsalves
@gregggonsalves.bsky.social

Word. “The future of biomedical research in the United States comes down to a race to see whether the biomedical research community can mobilize politically, access that vast but latent political power, before the White House can do enough sustained damage to make the whole question moot.”

E John Wherry reposted

Apoorva Mandavilli
@apoorvanyt.bsky.social

RFK Jr. said multiple times during his house and senate hearings today that no scientists have been fired from federal agencies. Our reporting has shown that hundreds, if not thousands, of scientists have been let go from NIH/CDC/FDA

E John Wherry
@ejohnwherry.bsky.social

Honored and humbled. I have been very fortunate to have worked with amazing, inspirational colleagues in my lab, at Penn and in the broader community. Science matters www.nasonline.org/news/2025-na...

nasonline.orgNational Academy of Sciences Elects Members and International Members - NASWASHINGTON — The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original res...

E John Wherry reposted

Joe Zackular
@joeyzacks.bsky.social

Congratulations to all of the new National Academy of Sciences members!! Special shout out to @ejohnwherry.bsky.social and Eric Skaar!!! So well deserved!

Heran Darwin, PhD@heran.bsky.social

National Academy of Sciences Elects Members and International Members - NAS www.nasonline.org/news/2025-na...

nasonline.orgNational Academy of Sciences Elects Members and International Members - NASWASHINGTON — The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original res...

E John Wherry reposted

Solving For Science
@solvingforsci.bsky.social

Congratulations to all the new members especially @ejohnwherry.bsky.social! National Academy of Sciences Elects Members and International Members - NAS www.nasonline.org/news/2025-na...

nasonline.orgNational Academy of Sciences Elects Members and International Members - NASWASHINGTON — The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original res...

E John Wherry reposted

Hensley Lab
@scottehensley.bsky.social

After 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors. www.nature.com/articles/s41...

nature.comBovine H5N1 binds poorly to human-type sialic acid receptors - NatureNature - Bovine H5N1 binds poorly to human-type sialic acid receptors

E John Wherry reposted

Jane Yinghui Huang
@janehuang.bsky.social

Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below! www.science.org/doi/10.1126/...

science.orgContinuous expression of TOX safeguards exhausted CD8 T cell epigenetic fateTOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.

E John Wherry reposted

Barack Obama
@barackobama.bsky.social

Right now, there’s an important race happening that will shape the Wisconsin Supreme Court for the next 10 years. Judge Susan Crawford is ready to protect the fundamental rights and freedoms of all Wisconsinites. Make a plan to vote early today — don’t wait until April 1st: wisdems.org/vote

wisdems.orgFind Your Voting Locations | WISDEMS Voter Protection TeamThis searchable map shows you early voting and dropbox info for hundreds of villages, towns, and cities across Wisconsin. Enter the address you're registered at and your options will pop up!

E John Wherry reposted

Angie Rasmussen
@angierasmussen.bsky.social

So the anti-vax organization founded by the current HHS secretary is hosting a dark mirror bullshit clone of the CDC’s website. No wonder they were in such a hurry to delete the CDC’s data.

E. Rosalie@erosalie.infoepi.com

🧵NEW: A CDC clone website is filled with false and misleading vaccine claims against a backdrop of false balance. The NGO (Children's Health Defense) led by the current HHS Secretary until December 2024 is hosting content for the CDC clone. infoepi.substack.com/p/cdc-clone...