Paul Knoepfler

Paul Knoepfler

@stemcells.bsky.social

Professor at UC Davis studying cancer & stem cell epigenomics. I also do outreach and blog The Niche http://ipscell.com Also stem cell YouTube channel http://cutt.ly/vcsev4J STAT column https://www.statnews.com/category/lab-dish-paul-knoepfler/

3.5K followers930 following814 posts

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Paul Knoepfler
@stemcells.bsky.social

Excited about my lab's new paper: Evidence for coordinate CTCF and histone H3.3 activities in K27M diffuse midline gliomas link.springer.com/article/10.1... Aiming for targetable epigenomic dependencies of this fatal childhood brain tumors #DIPG

link.springer.comEvidence for coordinate CTCF and histone H3.3 activities in K27M diffuse midline gliomas - Acta Neuropathologica CommunicationsUp to 80% of diffuse midline gliomas (DMGs) are characterized by a lysine to methionine driver mutation (K27M) in the tail of histone variant H3.3, pointing to likely roles for epigenetic mechanisms i...
Paul Knoepfler
@stemcells.bsky.social

I love this kind of stuff.

Simone Reber@simonereber.bsky.social

Not all nuclei are the same. We went to some of biology’s most exceptional nuclei 👉 dinoflagellates with genomes 80× ours 👉 Giardia’s twin nuclei 👉 ciliates carrying two nuclei in one cytoplasm & asked a simple question: what sets nuclear density? 🧵 Preprint: www.biorxiv.org/content/10.6...

Paul Knoepfler reposted

Cell Stem Cell
@cp-cellstemcell.bsky.social

Online Now! Programmable apoptosis circuits enable subtractive engineering of stem cell-derived organoids and embryoids #stemcells

dlvr.itProgrammable apoptosis circuits enable subtractive engineering of stem cell-derived organoids and embryoidsThe authors introduce a programmable synthetic biology framework for tissue construction from hiPSCs through subtractive multicellular engineering. By selectively removing undesired cells during development via synthetic apoptosis circuits, this approach enhances tissue maturation and refines morphogenesis across organoid and embryoid models.

Paul Knoepfler reposted

Paul Knoepfler
@stemcells.bsky.social

Weekly #stemcell & regenerative medicine reads: Trump’s Granddaughter gets MUSE cells (potentially an unapproved cellular drug?), fibroblast plasticity, unusual FDA warning ipscell.com/2026/10/week...

ipscell.comWeekly reads: Trump's Granddaughter gets MUSE cell injection, fibroblast plasticity, unusual FDA warning - The NicheA professor's weekly reads on stem cells and regenerative medicine including Trump's Granddaughter gets MUSE cell injection.

Paul Knoepfler reposted

The Guardian
@theguardian.com

‘Pure arrogance’: anger in Finland as Google illegally fells 250,000 trees for datacentre

theguardian.com‘Pure arrogance’: anger in Finland as Google illegally fells 250,000 trees for datacentreCompany ordered to stop work at two sites in country, which has found itself at forefront of tech firms’ latest push Behind a wire fence lies a vast gaping wound of earth. Before Google’s arrival a few months ago, an estimated quarter of a million trees occupied the 330 hectares (815 acres) of forest near the town of Muhos in rural northern Finland. Now they are all gone. After the tech company illegally stripped the entire area to build a datacentre – taking even the top soil with it – all that remains is a vast expanse of mud indented with the trail marks of machinery, puddles and mounds of earth, roots and branches. Residents say that brown water flowing off the site is going into a stream that feeds the Oulujoki River. Continue reading...
Paul Knoepfler
@stemcells.bsky.social

ICYMI: A new class action suit against what might be the largest chain of stem cell clinics in the US tells us a lot about where the clinic industry stands, its massive sales in the US, and the interplay between the FDA and state laws working against it ipscell.com/2026/10/new-...

ipscell.comNew class action suit vs QC Kinetix: tie to Florida stem cell law, potential impact on field - The NicheStem cell biologist discusses new class action QC Kinetix suit, relation to past settled proposed class action, and future implications.

Paul Knoepfler reposted

Paul Knoepfler
@stemcells.bsky.social

New class action suit vs large regenerative clinic chain QC Kinetix: claim has interesting tie to Florida stem cell law. I discuss the potential impact on field ipscell.com/2026/10/new-... Could Florida's law be less helpful overall to clinics than originally anticipated? @caulfieldtim.bsky.social

ipscell.comNew class action suit vs QC Kinetix: tie to Florida stem cell law, potential impact on field - The NicheStem cell biologist discusses new class action QC Kinetix suit, relation to past settled proposed class action, and future implications.

Paul Knoepfler reposted

Oliver Willis
@owillis.bsky.social

The thing with the billionaires is they won’t fucking leave us alone. It would be one thing if they made some product or service, fucked off, paid their bills and paid for rivers of cocaine or gold covered loincloths or whatever. But they insist society be structured around their every whim.

Paul Knoepfler
@stemcells.bsky.social

The NYT crossword continues it's long decline over the last 6 years or so. More work than fun or clever these days. Outdated. Clunky. Some puzzles feel AI generated. It's like slowly losing an old friend...

Paul Knoepfler reposted

Cheshire
@thatsregrettab1.bsky.social

@stemcells.bsky.social

Retraction Watch@retractionwatch.com

An investigation by Retraction Watch raises questions about the way Rod Rohrich, who is now editor emeritus at a journal he founded, has promoted preliminary and sometimes misleading research about products to which he has financial ties.

retractionwatch.comJournal founded by plastic surgeon touts studies of products he’s tied to – including one that has been retractedAn illustration of a cell secreting exosomes. Meletios Verras/iStock In a February 2018 editorial, Rod Rohrich, a plastic surgeon and the former president of the World Association of Medical Editor…
Paul Knoepfler
@stemcells.bsky.social

New class action suit vs large regenerative clinic chain QC Kinetix: claim has interesting tie to Florida stem cell law. I discuss the potential impact on field ipscell.com/2026/10/new-... Could Florida's law be less helpful overall to clinics than originally anticipated? @caulfieldtim.bsky.social

ipscell.comNew class action suit vs QC Kinetix: tie to Florida stem cell law, potential impact on field - The NicheStem cell biologist discusses new class action QC Kinetix suit, relation to past settled proposed class action, and future implications.

Paul Knoepfler reposted

Torie Bosch
@thekibosch.bsky.social

I've done a bit of personal writing over the years. Today I published by far the most difficult essay I've written. On @statnews.com today, I share the story of my mother, Regina Bosch. She was brilliant--three Ivy degrees--and funny and charismatic. She was also seriously mentally ill.

Paul Knoepfler reposted

Paul Knoepfler
@stemcells.bsky.social

Weekly #stemcell & #regenerative reads: G&D trio including on novel MYC functions, Regenative Labs sues FDA, OCT4 chemical sub, what to think of SpudCells, SRSF1 as an anti-aging factor? ipscell.com/2026/10/week...

ipscell.comWeekly reads: G&D trio, Regenative Labs sues FDA, OCT4 sub, SpudCells, SRSF1 as an anti-aging factor? - The NicheBiologist's weekly recommended reads: trio of G&D articles, Regenative Labs sues FDA, a chemical substitute for OCT4, SpudCells.
Paul Knoepfler
@stemcells.bsky.social

Weekly #stemcell & #regenerative reads: G&D trio including on novel MYC functions, Regenative Labs sues FDA, OCT4 chemical sub, what to think of SpudCells, SRSF1 as an anti-aging factor? ipscell.com/2026/10/week...

ipscell.comWeekly reads: G&D trio, Regenative Labs sues FDA, OCT4 sub, SpudCells, SRSF1 as an anti-aging factor? - The NicheBiologist's weekly recommended reads: trio of G&D articles, Regenative Labs sues FDA, a chemical substitute for OCT4, SpudCells.
Paul Knoepfler
@stemcells.bsky.social

ICYMI: A puzzling kind of stem cell is at the center of a burst in stem cell clinic type marketing in the US. I dig into what's going on with "Muse cells". Would the FDA regulate these drugs? ipscell.com/2026/10/amer... #stemcell

ipscell.comAmerica's growing Muse cell mess: Dezawa Muse cells, "counterfeits", & FDA compliance questions - The NicheStem cell biologist discusses how Dezawa MUSE cells pose a growing challenge to the FDA as more US clinics market them.

Paul Knoepfler reposted

Paul Knoepfler
@stemcells.bsky.social

America's growing Muse cell mess: Dezawa Muse cells, "counterfeits", & FDA compliance questions ipscell.com/2026/10/amer... a big spike in marketing of this enigmatic cells caught my attention #stemcells

ipscell.comAmerica's growing Muse cell mess: Dezawa Muse cells, "counterfeits", & FDA compliance questions - The NicheStem cell biologist discusses how Dezawa MUSE cells pose a growing challenge to the FDA as more US clinics market them.

Paul Knoepfler reposted

The Washington Post
@washingtonpost.com

Virginia high school students wanted to help their peers identify speedy and safe walking routes to school. They developed SafeWalkr, which combines data from Google Maps and street databases to map crosswalks, traffic and sidewalk coverage.

washingtonpost.comStudents created a program to make walking safer — and schools are now using itThree Northern Virginia high school seniors decided that because most map programs are for drivers, they would make one for pedestrians.

Paul Knoepfler reposted

Joshua Weitz
@joshuasweitz.bsky.social

The NIH proposal to conceal reviewer scores from program officers, investigators, and advisory councils is ill-conceived, introduces disproportionate weight to small percentile differences, diminishes the role of scientific peer review, and should be withdrawn in its entirety. a 🧵

joshuasweitz.substack.comWhat is NIH Leadership Trying to Hide from Researchers & the Public?A NIH proposal to conceal reviewer rankings of investigator-initiated research grants is ripe for misuse & demands a collective response (by October 13).

Paul Knoepfler reposted

Paul Knoepfler
@stemcells.bsky.social

Pop peptide politics: RFK Jr. reportedly will force quick access to unapproved peptide drugs like BPC-157 before required rulemaking ipscell.com/2026/10/pop-... Putting compounding and telehealth profits & ideology over biomedical science #peptides #stemcells

ipscell.comPop peptide politics: RFK Jr. reportedly will force quick access before required rulemaking - The NicheRFK Jr. reportedly will force quick access to sketchy peptides, part of an apparent plan to benefit peptide compounding and wellness firms.

Paul Knoepfler reposted

Bill Grueskin
@bgrueskin.bsky.social

July 31: Russia is sharing intelligence with Iran to launch assaults on US troops October 9: Trump is doing a diesel deal with Russia (which can now use that money to provide intelligence to Iran in launching assaults on US troops)

Paul Knoepfler
@stemcells.bsky.social

Pop peptide politics: RFK Jr. reportedly will force quick access to unapproved peptide drugs like BPC-157 before required rulemaking ipscell.com/2026/10/pop-... Putting compounding and telehealth profits & ideology over biomedical science #peptides #stemcells

ipscell.comPop peptide politics: RFK Jr. reportedly will force quick access before required rulemaking - The NicheRFK Jr. reportedly will force quick access to sketchy peptides, part of an apparent plan to benefit peptide compounding and wellness firms.

Paul Knoepfler reposted

Paul Knoepfler
@stemcells.bsky.social

ICYMI: Discussing one of the craziest stem cell videos I've ever seen. Scott Carney on: Adeel Kahn, Kardashians, Muse cells, Liveyon, Platinum Biologics, & more ipscell.com/2026/10/wild... #stemcells

ipscell.comWild Scott Carney stem cell 'buffet' video: Adeel Kahn, Kardashians, Muse cells, Liveyon, Platinum Biologics, & more - The NicheStem cell biologist discusses wild Scott Carney video on Adeel Kahn that touches on celebs, Dezawa Muse Cells, Liveyon, Platinum Biologics.
Paul Knoepfler
@stemcells.bsky.social

From @margaretmanto.bsky.social "Are stem cells the next peptides? These advocates think RFK Jr. could make it happen" www.statnews.com/2026/10/05/s... Really interesting piece. I would quibble about calling these folks "advocates". They want to cash in on less FDA oversight

statnews.comAre stem cells the next peptides? These advocates think RFK Jr. could make it happenPeptides gained legitimacy at the FDA after being embraced by MAHA. Advocates hope stem cell treatments will follow the same path.

Paul Knoepfler reposted

Norio Nakatsuji
@norionakatsuji.bsky.social

[In crude Ohio speech, Trump says he may not help the state if Democrats win] [“Just get out and vote," Trump said at a rally for candidates. "If you do that, we're going to win, and we're going to win big, and we're going to shove it up their ass."] www.reuters.com/world/us/tru...

reuters.comIn crude Ohio rally speech, Trump says he may not help if Democrats win"Just get out and vote," Trump said at a rally for Republican candidates. "If you do that, we're going to win, and we're going to win big, and we're going to shove it up their ass."
Paul Knoepfler
@stemcells.bsky.social

ICYMI: Discussing one of the craziest stem cell videos I've ever seen. Scott Carney on: Adeel Kahn, Kardashians, Muse cells, Liveyon, Platinum Biologics, & more ipscell.com/2026/10/wild... #stemcells

ipscell.comWild Scott Carney stem cell 'buffet' video: Adeel Kahn, Kardashians, Muse cells, Liveyon, Platinum Biologics, & more - The NicheStem cell biologist discusses wild Scott Carney video on Adeel Kahn that touches on celebs, Dezawa Muse Cells, Liveyon, Platinum Biologics.

Paul Knoepfler reposted

Paul Knoepfler
@stemcells.bsky.social

Wild Scott Carney stem cell video with buffet of topics: Adeel Kahn, Kardashians, Muse cells, Liveyon, Platinum Biologics, & more ipscell.com/2026/10/wild... Kind of tabloidy style video, but nice to see someone else tackling the unproven #stemcell clinic world

ipscell.comWild Scott Carney stem cell 'buffet' video: Adeel Kahn, Kardashians, Muse cells, Liveyon, Platinum Biologics, & more - The NicheStem cell biologist discusses wild Scott Carney video on Adeel Kahn that touches on celebs, Dezawa Muse Cells, Liveyon, Platinum Biologics.

Paul Knoepfler reposted

Paul Knoepfler
@stemcells.bsky.social

What to think about those mice with half-human brains from the Pasca Lab www.statnews.com/2026/09/30/x... My latest @statnews.com Stem cells grew human brain organoids, implanted in mice. Some surprises! Challenging ethics questions. Should more research have real-time ethics review?

statnews.comWhat to think about those mice with half-human brainsNew research involving giving mice a human cell-based cortex brings to mind “Flowers for Algernon” and “Pinky and the Brain,” writes STAT Lab Dish columnist Paul Knoepfler.