Broad Institute

Now accepting nominations for the 2027 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. ➡️ Submit by Dec 4, 2026: merkinprize.org

Our latest analysis of microbiome-reactive T cells, which revealed a unique, pro-inflammatory TMIGD2-hi subset of Th17 cells that expands in IBD and enriches spatially at the epithelium, is now online @ImmunityCP! www.sciencedirect.com/science/arti... @broadinstitute.org @mgbresearch.bsky.social

A cancer detection technology developed at the Broad Institute now powers a next-generation MRD test launched by Abbott. The Oncodetect® test is designed to find traces of cancer DNA in patients who have undergone treatment, and is the result of years of collaboration. broad.io/MAESTRO-news

To mark our tenth Anniversary month, watch HCA Co-Founder Aviv Regev reveal her hopes for the Human Cell Atlas initiative, and how it is already helping to improve medicine. #HumanCellAtlas #Healthcare

The integrated HCA v1 Human Gut Cell Atlas is now available on the HCA Data Portal! Integrating nearly 1 million single cells from 265 donors, the #Gut Atlas is a reference map to understand gut health and diseases like Crohn’s. Explore here buff.ly/X0Rfj39 #Genomics

Two weeks ago I shared that our lab received an NIH Director’s Transformative Research Award to build Encore, a platform to search for treatments across hundreds of rare genetic diseases at once. Thank you to everyone who reached out with congratulations, questions, and ideas!

Join us on Thurs. October 29, from 6-8 pm for Discovery After Dark! Experience science firsthand through interactive activities, take on the challenge of an Operation Outbreak simulation, and meet Broad scientists! Advanced registration required. Register: broad.io/DaD

Applications are open for the Klarman Fellowship at @broadinstitute.org! We are looking for postdoctoral researchers to join the GaMBiT Initiative to develop innovative technologies that translate human genetic discoveries into disease mechanisms, biomarkers, and therapeutic leads.

As we celebrate a decade of collaboration, HCA Co-Founder Sarah Teichmann shares why she and Aviv Regev joined forces to bring this international scientific consortium together. Hear Sarah tell the story. @teichlab.bsky.social #HumanCell Atlas

New work with Caroline Uhler's lab is out in @natcomms.nature.com. We developed StriMap, a deep learning model to predict TCR–peptide–HLA interactions, and used it to uncover bacterial peptides that activate an ankylosing spondylitis-associated TCR. www.nature.com/articles/s41...

Five Broad Institute members were elected to the @nam.edu this year: Anna Greka, Kim Stegmaier, Kathleen Burns, @jorsmo.bsky.social, and Michael Yaffe. We’re thrilled to have so many NAM members engaged in our community. Congrats, all!

Join us on October 29, from 6-8 pm for Discovery After Dark! Explore interactive exhibits, participate in hands-on activities, put your outbreak response skills to the test, and interact with Broad scientists! Advanced registration required. Register at: broad.io/DaD

Fabulous to see this editorial from @natbiotech.nature.com highlighting HCA achievements and technologies over the past 10 years, and the ambitious plans for the future. Watch this space! #HumanCellAtlas #Genomics

A new study led by Vamsi Mootha shows that a newly optimized hypoxia-inducing drug combination greatly improved symptoms of neurodegeneration in mouse models of rare mitochondrial disease as well as a model of Parkinson’s disease.

Congratulations to Broadies Yasha Ektefaie, @rahulg603.bsky.social, and Mohamed El-Brolosy on being named 2026 #STATWunderkinds!

Congratulations to @yerinchen.bsky.social and @ctspeng.bsky.social for receiving the NIH Director’s New Innovator Award, and to @jtneal.bsky.social for his NIH Director’s Transformative Research Award!

We’re delighted to announce that the HCA Organizing Committee (OC) has selected Muzz Haniffa and Alexandra-Chloé Villani to be the next Co-Chairs of the HCA OC, and Shyam Prabhakar and Holger Heyn as co Vice-Chairs. #HumanCellAtlas @mhaniffa.bsky.social @hoheyn.bsky.social

Survey of mitochondria proteomes across eukaryotes explores organelle’s role, suggests it originated late in eukaryotic evolution, and highlights possible drug targets for tropical diseases.

New method allows scientists to connect disease-linked regulatory genetic variants to the genes they control. These variants are more likely to influence disease risk if they alter chromatin accessibility that then changes gene expression.

Our single-nucleus immune multiome atlas is now out in @nature.com! 🧬 10M PBMCs from 1,108 @finngen.bsky.social donors recruited by Finnish Blood Service, profiled at @broadinstitute.org with chromatin accessibility and gene expression in the same nuclei, to trace how disease variants act 🧵👇

The @novo-nordisk.bsky.social is renewing its commitment to Broad with a $53M investment. With Danish scientists, the Center will leverage massive-scale data, AI, and cellular models to decode the genetic drivers of type 2 diabetes and obesity. broad.io/NNFCRenewal

To aid in virus outbreak responses, Broad researchers from @sabetilab.bsky.social and @fathom.info created Delphy.bio, a free web tool to reconstruct how a virus is spreading and changing using viral genomic data, reducing a months-long task into one that takes hours.

New method lets scientists watch gene activity unfold in living cells over time, by engineering cells to package their own RNA into virus-like particles they release, ready for researchers to collect and sequence.

New preprint from our collaboration with Caroline Uhler and @broadinstitute.org on TissueFormer, a new tool for predicting spatial gene expression from histology images at cellular resolution www.biorxiv.org/content/10.6...

A week-overdue 🧵on the newest paper from the Cimini lab- do you ever do spatial transcriptomics? If you do, and you want free extra phenotypic info, step in to learn more about "Evaluating integrative strategies for incorporating phenotypic features in spatial transcriptomics". 🧪 (1/x)

Nominations are now open for the 2027 Merkin Prize in Biomedical Technology! 🏆 This international $400,000 prize recognizes pathbreaking technologies that have improved human health through treatment, diagnosis, or prevention of disease. Learn more: merkinprize.org

Mechanistic machine learning for prediction of prime editing outcomes - @broadinstitute.org @hhmi-science.bsky.social www.nature.com/articles/s41...

OptiPrime, a new AI model from David Liu's lab, helps scientists choose the best pegRNAs to make a desired edit, avoiding slow and costly steps in the lab and streamlining development of gene-editing medicines for rare diseases.

The Cancer Dependency Map now includes data from dozens of 3D cancer models across 10 cancer types, revealing new dependencies and offering a more comprehensive resource for cancer research.

This Thursday, August 6, at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with @jbuenrostro.bsky.social: Uncovering Adversity's "Molecular Scars." Register: broadinstitute.swoogo.com/bds2026

Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells - @broadinstitute.org @hhmi-science.bsky.social www.nature.com/articles/s41...

New work with Ben Medoff's lab, online now! ADAMTS14 regulates YAP-driven fibroblast activation in IPF. We define an ADAMTS14–collagen V–focal adhesion pathway that contributes to $fibrosis, highlighting ADAMTS14 as a potential therapeutic target. doi.org/10.1093/ajrc...

Thank you Broad Institute of MIT and Harvard for this profile. The last 2 years have been an extraordinary moment of creativity and inspiration. If you’re interested in joining us, PM me! We’re building new methods, models and ML tools - we’re recruiting at all levels!

Shaped by a tumultuous childhood, Broad researcher and epigenomic tool-maker @jbuenrostro.bsky.social pivots to studying the biology of stress and adversity and finding new ways to boost resilience.

Join us on Thursday, August 6, at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with @jbuenrostro.bsky.social: Uncovering Adversity's "Molecular Scars." Register: broadinstitute.swoogo.com/bds2026

We're thrilled to announce that, along with @broadinstitute.org, @bostonchildrens.bsky.social, RARE Hope and partners, JAX was selected for ARPA-H THRIVE Award to advance gene editing platform for pediatric epilepsies and rare CNS diseases. 🧪🧬🧠

So excited to see this published! This method was a long time in the making and is now being widely used to balance scale with depth, especially for participants where unbiased sequencing approaches are so much more useful than arrays

Broad scientists developed the Blended Genome Exome (BGE) sequencing method, which delivers high-quality, unbiased data at a lower cost than existing gold-standard methods and makes large-scale genetic studies more feasible. @genetisaur.bsky.social

New research in Nature Methods from Project Ex Vivo shows AI models learn more from diverse cell states than from scaled datasets alone, a finding that could reshape how therapies are matched to patients. msft.it/6013vgE8l

The 2026 Richard N. Merkin Prize in Biomedical Technology honors Graeme Clark, Erwin Hochmair, Ingeborg Hochmair, Michael Merzenich, and Blake Wilson for developing the modern cochlear implant — a device used by more than 1 million people worldwide.