The Cecere Laboratory

The Cecere Laboratory

@cecerelab.bsky.social

The Cecere Laboratory at Institut Pasteur works on understanding the mechanisms of epigenetic inheritance during animal development. Contents curated by Germano Cecere | small RNAs | piRNAs | miRNAs | Chromatin | epigenetics | worms | www.cecerelab.com

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The Cecere Laboratory
@cecerelab.bsky.social

Very happy to see this work out in Cell Reports! Led by Ana Morao, who was the driving force behind the project from beginning to end. Great collaboration between @pasteur.fr, @ercanlab.bsky.social at NYU, and Legnini lab @ilegnini.bsky.social at Human Technopole. www.cell.com/cell-reports...

cell.comGenome architecture shapes transcriptional responses to topoisomerase depletion in C. elegansTranscription generates DNA supercoiling that must be resolved by topoisomerases. Morao et al. report that acute depletion of topoisomerases I and II in Caenorhabditis elegans globally impairs transcr...

The Cecere Laboratory reposted

Nature Structural & Molecular Biology
@natsmb.nature.com

New online: Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny

dlvr.itSoma-to-germline miRNA inheritance through yolk promotes stress resilience in progenyNature Structural & Molecular Biology, Published online: 22 May 2026; doi:10.1038/s41594-026-01816-5In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression and promote stress resilience in offspring.

The Cecere Laboratory reposted

Nature Structural & Molecular Biology
@natsmb.nature.com

New online: Yolk transports miRNAs to embryos and enhances progeny stress resilience

dlvr.itYolk transports miRNAs to embryos and enhances progeny stress resilienceNature Structural & Molecular Biology, Published online: 27 May 2026; doi:10.1038/s41594-026-01822-7This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory small RNAs, such as microRNAs, from somatic tissues to the germline and embryos. This pathway links the maternal environment to inherited regulatory information and stress resilience in the next generation.

The Cecere Laboratory reposted

Nature Structural & Molecular Biology
@natsmb.nature.com

ICYMI: New online: Yolk transports miRNAs to embryos and enhances progeny stress resilience

dlvr.itYolk transports miRNAs to embryos and enhances progeny stress resilienceNature Structural & Molecular Biology, Published online: 27 May 2026; doi:10.1038/s41594-026-01822-7This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory small RNAs, such as microRNAs, from somatic tissues to the germline and embryos. This pathway links the maternal environment to inherited regulatory information and stress resilience in the next generation.
The Cecere Laboratory
@cecerelab.bsky.social

If you are interested in the story behind our recent study in Nature Structural & Molecular Biology, our accompanying Research Briefing discusses the questions that motivated the work, the main findings, their implications, and the path that led us there. @pasteur.fr rdcu.be/flcpv

rdcu.beYolk transports miRNAs to embryos and enhances progeny stress resilienceNature Structural & Molecular Biology - This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory small RNAs, such as microRNAs,...
The Cecere Laboratory
@cecerelab.bsky.social

Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation. rdcu.be/fj8Er #Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu

nature.comSoma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny - Nature Structural & Molecular BiologyIn this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...
The Cecere Laboratory
@cecerelab.bsky.social

🍽️🧬 How do diet and gut microbes shape fertility across generations? 🪱🔬 Our Laboratory at #InstitutPasteur is recruiting a PhD student to study epigenetic inheritance of fertility using C. elegans. Fully funded via the International PPU program. Apply now! 🌍 #PhDposition #Epigenetics #Inheritance

Institut Pasteur | 130 years of biomedical research@pasteur.fr

🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...

The Cecere Laboratory reposted

Institut Pasteur | 130 years of biomedical research
@pasteur.fr

Replying to @pasteur.fr

L’Institut Pasteur décide de quitter X (ex-Twitter) pour rejoindre BlueSky ! 🦋 L’Institut Pasteur a pris cette décision en raison de plusieurs dérives graves constatées sur la plateforme X depuis son rachat. Rejoignez-nous pour continuer à défendre la science ! www.pasteur.fr/fr/espace-pr...

pasteur.frL’Institut Pasteur a décidé de quitter XL’Institut Pasteur, organisme de recherche engagé depuis plus de 130 ans dans la lutte contre les maladies infectieuses, le partage des connaissances et la défense de la science, a décidé de quitter l...

The Cecere Laboratory reposted

Institut Pasteur | 130 years of biomedical research
@pasteur.fr

The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...

pasteur.frInstitut Pasteur decides to leave XThe Institut Pasteur, a research organization which for more than 130 years has been committed to tackling infectious diseases, sharing knowledge and defending science, has decided to leave X because ...

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