Cordero-Vásquez Lab

Cordero-Vásquez Lab

@cvlab.bsky.social

👨🏻‍🔬👩🏻‍🔬🥼🔬🧬 https://www.corderovasquezlab.com

617 followers304 following29 posts

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Excited to share our new paper in Science Advances @science.org In this work, we uncover how a disease-linked TRPC3 mutation, together with a cerebellum-specific splice isoform, stabilizes the channel in an open state, drives Calcium overload, and promotes neurodegeneration. (1/4)

science.orgFunctional and structural basis of a hypermorphic TRPC3 variantStructural snapshots capture an ataxia-linked overactive ion channel in its open state and reveal a druggable site for inhibition.

Excited to share our new paper in Science Advances @science.org In this work, we uncover how a disease-linked TRPC3 mutation, together with a cerebellum-specific splice isoform, stabilizes the channel in an open state, drives Calcium overload, and promotes neurodegeneration. (1/4)

science.orgFunctional and structural basis of a hypermorphic TRPC3 variantStructural snapshots capture an ataxia-linked overactive ion channel in its open state and reveal a druggable site for inhibition.
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We are grateful to all the authors and collaborators who made this study possible. Special thanks to everyone in the Cordero-Morales and Vásquez laboratories (especially Briar Bell, Angela Jaramillo-Granda, and Luis Romero), as well as to our collaborators. www.science.org/doi/10.1126/... (3/4)

science.orgFunctional and structural basis of a hypermorphic TRPC3 variantStructural snapshots capture an ataxia-linked overactive ion channel in its open state and reveal a druggable site for inhibition.

Excited to share our new paper in Science Advances @science.org In this work, we uncover how a disease-linked TRPC3 mutation, together with a cerebellum-specific splice isoform, stabilizes the channel in an open state, drives Calcium overload, and promotes neurodegeneration. (1/4)

science.orgFunctional and structural basis of a hypermorphic TRPC3 variantStructural snapshots capture an ataxia-linked overactive ion channel in its open state and reveal a druggable site for inhibition.

The Cordero Vásquez Lab is starting the year on a high wheel (see below) with our latest work on the C. elegans PIEZO channel: “Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade”: www.sciencedirect.com/science/arti... 1/5

sciencedirect.comStructures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal bladePIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define t…
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4. The pore-distal, N-terminal blade is dispensable for mechanoactivation: the intermediate isoform is not only functional, but also inactivates more slowly than the long isoform. 5. The intermediate isoform induces larger membrane deformation than the long isoform. 4/5

The Cordero Vásquez Lab is starting the year on a high wheel (see below) with our latest work on the C. elegans PIEZO channel: “Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade”: www.sciencedirect.com/science/arti... 1/5

sciencedirect.comStructures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal bladePIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define t…

Briar and Angela (CV Lab) solved three structures from heavily spliced worm isoforms. Along the way —while solving the structures, characterizing their function, and evaluating effects on membrane curvature— we ran into several surprises: 2/5

1. The longest isoform resembles a Mercedes-Benz steering wheel in top view. 2. The long and intermediate isoforms are semi-flattened and differ from the mammalian domes. 3. Multiple blade–cap contacts stabilize a “toggle-down” conformation. 3/5

Our results highlight cytoskeletal dysregulation as a key driver of ion channel and behavioral deficits, and suggest that actin-binding proteins may be targets to enhance motor coordination and spatial learning in AS. 5/6

In Angelman syndrome (AS), disrupted F-actin affects mechanosensitive and glutamatergic signaling. We show that a first-in-class, selective cofilin inhibitor (SZ-3) stabilizes the actin cytoskeleton, increases cellular stiffness, restores PIEZO2 function in DRG neurons and glutamate-evoked 3/6

The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2

Cordero-Vásquez Lab reposted

The Nobel Peace Committee sent a clear message to someone else in awarding the Prize to Ms. Machado: ”But democracy is also in retreat internationally. Democracy – understood as the right to freely express one’s opinion, …is the foundation of peace both within countries and between countries.” 👏

Cordero-Vásquez Lab reposted

PIEZO1 is abnormally overactive in sickle red blood cells (humans and mice). In mice, an EPA-enriched diet normalized PIEZO1 and reduced hemolysis, hypoxia-induced sickling, and downstream inflammation, suggesting a potential dietary strategy to support people living with sickle cell disease. 2/3

Cordero-Vásquez Lab reposted

Cordero-Vásquez Lab reposted

Cordero-Vásquez Lab reposted

Colorado's Rep Brittany Pettersen (D) flew cross-country with her one-month-old to vote against the GOP budget tonight. Dems ended up one vote short. Pettersen was part of an unsuccessful bipartisan push to allow new mothers to vote remotely. #copolitics

Cordero-Vásquez Lab reposted

My colleague Dan beat me to the punch but I am so thankful that my hometown paper (and others) was willing to share this with the community.

Daniel Gorelick@danielgorelick.bsky.social

My colleague @rnareylab.bsky.social wrote this editorial for her hometown area newspaper. Well done & more please! www.heraldbanner.com/opinion/colu...

Cordero-Vásquez Lab reposted

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.

Cordero-Vásquez Lab reposted

Please help us advertise this new opening 🧠 in our research group. I am happy to answer any queries about it.

The Sensory Transduction and Nociception Group @painchannels.bsky.social at @neuroalc.bsky.social offers a 1-year (extendable to 3) postdoctoral position. The call is open until the position is filled. More info 👇 in.umh-csic.es/en/ofertas/1...

Cordero-Vásquez Lab reposted

While I realize this is not relevant to many of the present day discussions, the remarkable similarity of organisms at the biochemical, genetic, cellular, and physiological levels is not understood by many people. 1/n

Cordero-Vásquez Lab reposted

New paper‼️— from #PMB Griffith Lab! They show that sodium channels play unique roles in proprioceptive encoding. They also studied effects on skeletal muscle, and a dev dependent role for Nav1.6 in proprioceptive spinal circuits. www.science.org/doi/10.1126/...

science.orgDifferential encoding of mammalian proprioception by voltage-gated sodium channelsVoltage-gated sodium channels differentially encode mammalian proprioception via distinct cellular localization patterns.

Cordero-Vásquez Lab reposted

Thrilled to share the most recent pub from the Griffith Lab! We show that sodium channels play unique roles in proprioceptive encoding. We also found some really cool effects on skeletal muscle, and a dev dependent role for Nav1.6 in proprioceptive spinal circuits www.science.org/doi/10.1126/...

science.orgDifferential encoding of mammalian proprioception by voltage-gated sodium channelsVoltage-gated sodium channels differentially encode mammalian proprioception via distinct cellular localization patterns.

Cordero-Vásquez Lab reposted

Congratulations to #BlackInBiophysics Founder @stevenssostre.bsky.social and #BIBPS Board Member @jjalston.bsky.social on this extraordinary accomplishment!!! 🥳🥳🥳 We are PROUD of you and wish you the best in your careers! 👏🏾👏🏾👏🏾 @biophysicalsoc.bsky.social

HHMI@hhmi-science.bsky.social

Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!

Cordero-Vásquez Lab reposted

How hard do bacteria-eating nematodes bite in order to break the bacterial cell wall? Check out our new paper, led by Jason Casar & collab with Jen Dionne, using pressure sensing beads that change color upon compression (bluetorial coming soon) rdcu.be/d5n7v

rdcu.beUpconverting microgauges reveal intraluminal force dynamics in vivoNature - Nanoparticle-based ‘microgauges’ are developed for in vivo force sensing and deployed in C. elegans to investigate how mechanical force correlates with electrical signalling in...

Cordero-Vásquez Lab reposted