David Davies-Payne

📌 I've made a page for some key recent scientific papers for #MECFS and #LongCovid. Nearly all have accessible PDF links (open-access or via PubMedCentral). Aiming to keep updated as new papers drop, but with limited numbers. www.ddp.nz/me-cfs-lc/re...

"I think I saw four or five different specialists because the symptoms that I was having, they were across multiple [body] systems. All the specialists said 'this is ME' and we don't want it to be that because there's nothing out there for it." #MECFS #LongCovid www.bbc.com/sport/athlet...

"…18% of patients with coronary function testing-confirmed ANOCA meeting diagnostic criteria for #MECFS. Invasive cardiopulmonary exercise testing (iCPET) in patients with [both] reveals a primary peripheral, not cardiac, limitation to exercise." #Cardiology journals.physiology.org/doi/10.1152/...

"While these findings are preliminary and the hypoxic challenge not equivalent to physical exertion, the experimental findings of our study support the concept of impaired neuro-metabolic and vascular adaptive capacity in ME/CFS." #MECFS #MRI #neuroimaging www.medrxiv.org/content/10.6...

This is very welcome news. It will extend the initial findings from DecodeME at the University of Edinburgh, led by Prof Chris Ponting @cgatist.bsky.social #MECFS #LongCovid

1) 1) Interesting interview of Dr. Audrey Ryback by David Tuller. Her recent study showed that there are likely two age peaks for when people get ME/CFS. It helps to characterise ME/CFS as a unique clinical entity.

A quote from my new piece, The Inventory of Loss. “The grief is ongoing because the illness is ongoing, and new losses arrive as old ones calcify into something you have learned to carry.” darthfoo.substack.com/p/the-invent... #LongCOVID #MECFS #PwME

My good friend Tom Micklem who I first met back in university is running the London Marathon to raise money for Action for ME! @actionforme.bsky.social You can read about it and donate here, good luck Tom!: 2026tcslondonmarathon.enthuse.com/pf/tom-micklem

A quote from my piece, The Debt Came Due. “There is a version of my life that exists in my memory like a photograph from a trip I’ll never take again. In that version, I wake up and get out of bed without negotiating with my body first.” #LongCOVID #MECFS #PEM #PwME substack.com/home/post/p-...

I wrote about the findings from the inquiry about the impact of the pandemic on the NHS, and the mistakes of the first year. I hope it makes you angry - it should make us all angry. open.substack.com/pub/christin...

SARS-CoV-2 (COVID-19) is anything but a common cold. Each infection can cause severe illness and even death in children at rates +++ higher than the common cold. It triggers long-covid (now the most common chronic illness in children) and other cobditions like diabetes. Not the common cold.

Patients were central to the team that found ME/CFS is most likely to start in the teens and early middle age. Two age peaks is unusual for any disease and might help unravel ME's causes. academic.oup.com/ooim/advance... 1/ team credits to follow

"findings reveal widespread alterations in multiple NII- derived metrics across white matter fibres, suggesting complex inflammatory processes affecting white matter microstructure in ME/CFS patients." #MECFS #MRI #neuroimaging #radiology onlinelibrary.wiley.com/doi/10.1002/...

🙋🏻‍♀️💪🏼💉🩸 Request for subjects for a research study - Women aged 18+ - In #Melbourne #Victoria - With #LongCovid & #MECFS Looking for a signature in blood platelet microRNAs One blood sample & questionnaire Study being run by - Dr Sarah Annesley - Dr Daniel Missailidis @danielmissailidis.bsky.social

The proteome (>7,000 circulating proteins) in people with ME/CFS exhibits immune system, vascular and metabolic dysregulation compared with controls (and likely homologous in #LongCovid) www.cell.com/cell-reports...

Exciting to read about some of the expensive ME/CFS & long Covid research planned in Germany (using some of€500 million budget) including that using long-term samples which allow comparisons of samples before and after developing the conditions www.helmholtz.de/en/newsroom/... #LongCovid #MEcfs

"… revealing widespread transcriptional remodeling across both innate and adaptive immune compartments." "Mechanistically, we identify Galectin-9–TIM-3 interaction as a potential pathway driving ɣ𝛿 and MAIT cell depletion in LC." #MECFS #LongCovid #GDTcells www.frontiersin.org/journals/imm...

To understand the catastrophic turn in U.S. health policy, follow the money paulkrugman.substack.com/p/how-the-ka...

Huh. It's almost as if betting the world on a game of "let's pretend" between a bunch of pseudoscientific cosplayers wasn't a great public health strategy for dealing with COVID after all. 🤔 It must be nothing though. I'm sure we could trust management-class MDs to tell us if they got it wrong...

"We found that plasma concentrations of MASP-2/C1Inh were significantly higher in patients with long COVID relative to healthy convalescent individuals, indicating sustained activation of the lectin complement pathway." #LongCovid onlinelibrary.wiley.com/doi/10.1111/...

Eminence-based medicine ;-)

“This year, renewables surpassed coal as a source of electricity worldwide, and solar and wind energy grew fast enough to cover the entire increase in global electricity use from January to June according to energy think tank Ember“ @science.org’s Breakthrough of the Year is the growth of renewables

More evidence-based disease mechanisms = less #stigma for Long COVID patients! 👇👇👇👇 Human #genetics implicate thromboembolism in the pathogenesis of #LongCOVID in individuals of European ancestry. www.nature.com/articles/s44...

fMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:

Well done & thanks to these healthcare professionals (PTs)/similar ( @sunsopeningband.bsky.social @profmarkfaghy.bsky.social et al) for this new e-letter 👏 "In the Long Run, Misleading Participants Will Harm More Than Help in Long COVID Research" bmjopen.bmj.com/content/15/1... #LongCOVID #PEM

I’m excited to share my latest work, “The Small Life.” It explores the little things that still bring me joy as I navigate #LongCovid and #MECFS. #ChronicIllness substack.com/home/post/p-...

I never met Alice Wong in person, but like so many great writers I felt like I knew her - and unlike many, when I emailed she emailed right back. ❤️ Peds neurologist @dianacejasmd.bsky.social has a beautiful essay in Wong's Disability Visibility collection - I recommend it to physicians. #neurosky

After some hardcore protesting in Germany!! Well done‼️‼️🇩🇪🇩🇪 "The coalition plans to invest 500 million euros by 2036 in the fight against #LongCovid and chronic fatigue syndrome (#MECFS)." www.spiegel.de/politik/karl...

From Daniel Missailidis, PhD @danielmissailidis.bsky.social (Victoria, Australia) People with ME/CFS, Long Covid, and healthy volunteers sought drive.google.com/drive/folder... #MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #LongCovid

WTAF. This is an absolute travesty. Teen Vogue has consistently been a light in the dark and once again the corporate overlords just end it all.

Long Covid Is Real — And It’s Changing an Entire Generation Hundreds of thousands of kids in America are struggling with an illness that many doctors and schools refuse to recognize.e Feature: www.rollingstone.com/culture/cult...

"described for the first time widespread abnormalities in the function of unmyelinated C fibers, both somatosensory and sympathetic, that could represent a common pathophysiological mechanism explaining the multiplicity of symptoms in #longCOVID" #MECFS onlinelibrary.wiley.com/doi/10.1002/...

The Irish health service has initiated a process to develop a clinical guideline for ME (#MyalgicEncephalomyelitis). I am honoured to be part of its Steering Group The process so far has been extremely progressive I am hugely optimistic that a world-leading guideline will be produced #pwME #MECFS

“DecodeME shows the incredible level of support that the ME/CFS patient community can give to research that involves them on a deep and meaningful level. Without the community, we could not have achieved all that we have.” Andy Devereux-Cooke (PPI Member and Co-Investigator)