David A. Delgadillo

There's been a rich connection between electron diffraction and the nature of the chemical bond over the years. Here, we've shown how you can leverage electron diffraction to discover and characterize novel natural products. @caltechcce.bsky.social @uclacb.bsky.social pubs.acs.org/doi/10.1021/...

Linus Pauling's landmark paper "The nature of the chemical bond. IV...." appeared 94 years ago this month in JACS; it introduced electronegativity. #ChemSky #Chemistry #Chemchat 🧪 Read it here: scarc.library.oregonstate.edu/coll/pauling...

Beckman Institute Spotlight: The mission of the Caltech Beckman Research Institute is to “invent methods, instrumentation, and materials that will open new avenues for fundamental research in the chemical and biological sciences, and to provide technological support” for those efforts.

Hosea Nelson has been selected to lead a team that will receive $17 million from the NSF to create a "programmable cloud laboratory," an automated lab that will allow scientists and AI agents to conduct experiments remotely, analyzing and storing data online. https://bit.ly/4h6ZuhU

New paper with @barriewilks.bsky.social. There are many reports on fasamycins and formicamycins (aka accramycins, naphthacemycins, streptovertimycins). Here, we unambiguously solve their structures and stereochemistry. A great effort, led by Dr Edward Hems pubs.acs.org/doi/10.1021/...

I’m looking for an automated way to read others’s scientific data without giving credit or acknowledgement, and also claim full credit for insights from it. And I want it to have a fitting name OAI: say no more

1. Dodgers 2. Whoever is playing the Giants. 3. Whoever is playing the Astros.

Congratulations to David Delgadillo and Jacob Rothbaum on being awarded the inaugural Nemko Mentorship Prize! 🎉 https://beckmaninstitute.caltech.edu/funding-opportunities/beckman-institute-mentorship-prize

My quote of the day Science is the search for truth, that is the effort to understand the world: it involves the rejection of bias, of dogma, of revelation, but not the rejection of morality. Linus Pauling

For a quick summary @uclacb.bsky.social al for the nice writeup of our paper www.chemistry.ucla.edu/news/innovat...

“The enormous diversity of fungal genomes...offers catalogs of enzymes, secondary metabolites & other parts lists for biotechnology, bioenergy & biomaterials."—Igor Grigoriev, Fungal & Algal Program Head. 🖥️🧬🍄🍄‍🟫 https://jgi.doe.gov/user-science/science-stories/mapping-earths-hidden-fungal-kingdom

Once every 5 years, scientists all over the world gather in Hawaii for the International Chemical Congress of Pacific Basin Societies: cen.acs.org/acs-news/mee... #Pacifichem2025 #Pacifichem #chemsky 🧪

Because biology is so flexible, the genetic code is sometimes tweaked to add additional amino acids into select proteins. It turns out that some archaea, microorganisms distinct from bacteria and eukaryotes, have gone one step further. cen.acs.org/biological-c... #chemsky 🧪

New in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: https://ow.ly/pIWQ50XtEtM

[6+4] Cycloadditions! Introducing our first dive into this fascinating subject in a very enjoyable collaboration with Ken Houk and his team. Congrats to Harrison and Tufan! pubs.acs.org/doi/10.1021/...

@dmeremin.bsky.social Absolutely crushed it with this automated workflow! It ain’t about the size of your crystals, nor the way that they look, that matters…it’s all about how they diffract! Cheers to the whole team!

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

📢 New preprint: Experiment-guided AlphaFold3 resolves accurate protein ensembles. doi.org/10.1101/2025... AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇

‘Economics Nobel prize won by researchers who showed how science boosts growth’ by @philipcball.bsky.social in @nature.com www.nature.com/articles/d41...

Metabolic controls on the carbon isotope fractionations of bacterial fermentation www.pnas.org/doi/abs/10.1... #jcampubs

The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel... #ChemNobel #Chem #Chemistry #chemsky 🧪

When was the NSF-GRFP eligibility change implemented? #chemsky

A new electron diffraction technique could make it easier to study molecules that need to remain solvated at all times.

❄️ NEW PRE-PRINT ❄️ Happy to see our latest work online. Here we present a super simple solution to the preferred orientation problem in single particle cryo-EM: the use of ultrasonic excitation during vitrification! Details in the 🧵 below... #cryoEM #structuralbiology

is the dimer core of the H-cluster of FeFe hydrogenase formed by rSAM chemistry in HydE? pubs.acs.org/doi/full/10....

Trying to do more with less 🙂‍↕️

ACS Council approves the petition to establish the Committee on the Advancement of LGBTQ+ Chemists, 86% to 14%. #chemsky 🧪⚗️ #acsfall2025

Scientists’ role in defending democracy www.science.org/doi/10.1126/... Let's all support this vital need: the ability to tell the truth. 💪 "Those in the science community who are willing & able to be more visible can step up. Acting together will be more impactful than going it alone."

Defending US democracy: the role of scientists @science.org www.science.org/doi/10.1126/...

#ChemSky #ACSFall2025 Huge thank you to Prof. Isaiah Speight, Prof. Kensha Clark, and Prof. Davita Watkins for organizing this amazing lineup of impressive speakers. Hosted by organicdivision.org POLY and INOR. Thank you to ACS President Dr. Phillips for elevating this to a Presidential Symposium

@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪

Natural products (NPs) play a crucial role in medicine, inspiring over 50% of the drugs on the market. 🔎In this work, the team used an 'arrayED' workflow, that enabled high-throughput screening for crystalline NPs amenable to microcrystal electron diffraction (microED). 🔗 ccdc-info.com/3GP4yb2

Check out the stunning cover featuring recent paper from @hoseanelson.bsky.social Lab, led by our one and only @daverdude.bsky.social! He discovered an entire class of natural products using microED powered by arrayED @caltech.edu @caltechcce.bsky.social @uclacb.bsky.social

On the front cover of this week's issue: "Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites" Read it here 🔗: buff.ly/F6E8Ygs #ChemSky #JACS

Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes pubmed.ncbi.nlm.nih.gov/40720654/ #cryoEM

New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation. Learn more in this week's issue: scim.ag/44uRorm

I was first introduced to the potential of electron diffraction through the Pipeline back in 2018…full circle moment #chemsky

🔓Don't miss this #OpenAccess Highlight from @nadineziemert.bsky.social‬, Ludek Sehnal & co @unicampoficial.bsky.social‬ & @unituebingen.bsky.social‬ covering genomic insights to drug discovery of Antarctic bacterial natural products #natprod #secmet Check it out here🔽 pubs.rsc.org/en/content/a...

α-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via "Catalytically Correct" Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery? pubmed.ncbi.nlm.nih.gov/40401103/ #cryoEM

Self-supervised learning of molecular representations from millions of tandem mass spectra using DreaMS www.nature.com/articles/s41...

Crystallography legend Dorothy Crowfoot Hodgkin was born 115 years ago today. She cracked the structure of penicillin, vitamin B-12 (for which she was awarded the Nobel Prize), and ultimately, in 1969, the 788 atom structure of insulin. tinyurl.com/5n76x7n3 #WomenInSTEM #Chemistry #Physics 🧪

Coming to a TEM near you! Nice work @dmeremin.bsky.social and team! #ChemSky

This is absolute bullshit. Michael is one of the most creative scientists I've ever met, exactly the type of work the country should be investing in