Daniel Lipka

🧵 NEW PAPER in @bloodjournal.bsky.social! Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? 🤔 #AML #Epigenetics Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇

Tomorrow: Prof. Constanze Bonifer and Dr. Daniel Lipka share insights from their research and discuss how epigenetic approaches are advancing the field from clinical diagnosis to molecular disease mechanisms. Register for free: iseh.org/Webinars-Eve....

Neue Erkenntnisse zu akuten Leukämien: Bestimmte Mutationen liefern Ansatzpunkte für gezieltere Therapien Forschende des NCT Heidelberg und des Deutschen Krebsforschungszentrums (@dkfz.bsky.social) haben erstmals systematisch ermittelt, wie bestimmte Mutationen akute myeloische Leukämien fördern.

‼️ Pre-print alert from the Lipka lab ‼️ Our latest work “Hierarchical classification of hematologic malignancies using epigenetic and genetic information” is now online! www.biorxiv.org/content/10.6... Thanks to all colleagues who contributed to this work! 🙏

Hierarchical classification of hematologic malignancies using epigenetic and genetic information https://www.biorxiv.org/content/10.64898/2026.07.02.735835v1

‼️ Pre-print alert from the Lipka lab ‼️ Our latest work “Hierarchical classification of hematologic malignancies using epigenetic and genetic information” is now online! www.biorxiv.org/content/10.6... Thanks to all colleagues who contributed to this work! 🙏

😱 Seeing the global temperature change like this is absolutely shocking.... showyourstripes.info/c/globe

I’m excited to share that my PhD paper is officially out now in @bloodjournals.hematology.org Check out our discovery of how mutant IDH1 but not IDH2 leads to a lineage-specific differentiation block via epigenetic repression of lineage programs! 📄 Paper link below: 👇 doi.org/10.1182/bloo...

Data manipulation at a breathtaking scale by commercial providers of crucial research reagents. As if the few remaining lab scientists didn't face enough obstacles already.

Please RT: Opportunity to join us as technician! We are looking for a technician to support us in our projects in MPN and other myeloid malignancies using epigenomics on primary samples and PDX mouse models. Where: @carrerasijc.bsky.social When: Anytime. What: 👉https://sl1nk.com/0ekf3z6

In this Blood Cancer Discovery study, the authors demonstrate that oncogenic PTPN11 mutations enhance cellular plasticity. This leads to partial restoration of fetal molecular programs, creating new therapeutically exploitable vulnerabilities. buff.ly/QiXstYy

Same mutation ≠ same leukemia. Wagenblast et al. show: • fetal HSCs readily transform • postnatal HSCs become resistant • fetal programs create targetable vulnerabilities Ontogeny matters: state-of-origin shapes biology & therapy response. doi.org/10.1158/2159... #pediatric #AML #stemcells

JMML stem cells aren’t epigenetically “stuck” in a fetal state. They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model. doi.org/10.1158/2643... #JMML #epigenetics #hematology #cancer

New Spotlight in @aacrjournals.bsky.social #Oncogene × #Ontogeny × #Plasticity shape leukemia biology & therapy response. Two complementary studies show: mutations alone don’t explain disease behavior—developmental state and cellular plasticity matter. aacrjournals.org/bloodcancerd... 🩸🧬 EpiSci

Staying Current in Data Science and Computational Biology: 2026 Edition. Part 3 in a series of posts going back 14 years. doi.org/10.59350/2na...

You’ll help build interoperable, FAIR tools across @scverse.bsky.social and @bioconductor.bsky.social ecosystems. You will work together with a cross-institute team composed of @lucamarconato.bsky.social, @arturmansl.bsky.social and many contributors from #scverse and #Bioconductor!

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇 www.sciencedirect.com/science/arti...

Neue Erkenntnisse zu frühkindlicher Leukämie: Leukämiezellen können Programme aus der fetalen Entwicklung erneut aktivieren. Die Ergebnisse eröffnen neue Angriffspunkte für Diagnostik und Therapie. www.nct-heidelberg.de/das-nct/news... @dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social

👉🏼 @milsommick.bsky.social talking about the role of inflammation on HSC aging in the “Game of Clones” Scientific Session at #ASH25. #epigenomics #hematopoiesis #HemeSky @dkfz.bsky.social

Interested in DNA methylation and want to hear what we can learn from it regarding lineage commitment decisions in #hematopoiesis? #ASH25 #epigenomics #HemeSky

Very happy and proud to see this story finally published! 🎉🥳 #epigenetics #hematology #jmml #leukemia

The future of hematological genomics is here. The ASH HematOmics Program (ASHOP) developed with St. Jude & the Munich Leukemia Laboratory offers free access to powerful genomic visualization tools for blood disease research. 🔗 https://ow.ly/G7Ol50XukwQ #Genomics #HemeSky #MedSky

The figures from this book are all freely available through @figshare.com, hopefully helpful for presentations and teaching: figshare.com/projects/Epi... Please let me know if you find any inaccuracies and I'll fix them. I've already updated one of the figures. #EpigeneticsBook

Great to meet friends and colleagues at this year’s EWOG-MDS meeting in Berlin. We had great discussions and developed new project ideas and collaborations with the aim of improving risk stratification and patient care for JMML patients. #jmml #ewogmds #precisionmedicine www.ewogberlin2025.org

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

Of interest to the #epigenomics, #dnamethylation, #neurooncology, #oncology and #precisionmedicine communities! 🧬

DNA-methylation-based deconvolution can be a powerful tool for identifying novel disease subgroups. In our paper in Acta Neuropathologica, we show how this can be leveraged in IDH-mutant gliomas - specifically in oligodendrogliomas. doi.org/10.1007/s004...

Epigenetics Update - Fluctuating DNA methylation tracks cancer evolution at clinical scale go.nature.com/3Ve4OUy #Epigenetics #Cancer #DNAme #DNAm --- Empower your research with high-res epigenetic insights at epigenometech.com

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

Still two weeks left to apply to the #postdoc position in my lab via the @dkfz.bsky.social fellowship program. #epigenomics #hematology #leukemia #computationalbiology #precisiononcology

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

+++ Postdoc Opportunity +++ My lab is looking for researchers interested in combining cutting edge #genomics, #epigenetics and #AI for precision oncology in pediatric #leukemia. www.dkfz.de/fileadmin/us... Applications via the #DKFZ postdoc program: www.dkfz.de/en/karriere/...

Epigenetics Update - Thymic epithelial cells amplify epigenetic noise to promote immune tolerance go.nature.com/45srCWG Andrew S. Koh (University of Chicago) reporting in Nature #Epigenetics #Noise #Chromatin #Immunity --- High-resolution insights without cell sorting; epigenometech.com

🧵Radiotherapy immune signaling is modular, redundant — and has a limit. Together with @joschakraske @peterhuber_hd @halama_immuno @UKHD_radonc our new study in fully human systems shows that: t.co/GzH3N6gElf 1/9

Plant #epigenetics colleagues, is this the consensus opinion? "...these methylation marks and epiallelic variations found in natural populations are mainly attributed to genetic variations in epigenetic machinery and transposable element (TE) insertions" pmc.ncbi.nlm.nih.gov/articles/PMC...

I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾 👉 rdcu.be/ezA5o