@denklab

Our newest preprint is out! 🥳 Neuroscientists and rheumatologists - this one is for you! I'm also delighted that we seem to have finally found a single molecule apparently capable of inducing peripheral sensitization in cultured neurons - in the absence of any other supporting cells.

We are hiring! www.linkedin.com/posts/teodor...

The SCORE investigation of repeatability and credibility is a lot. There are a few ways to get your head around it. 1: The Nature collection includes 3 papers from SCORE, an amazing paper from @i4replication.bsky.social and several commentaries about the work. www.nature.com/collections/... 1/

@denklab.bsky.social leads an international consortium awarded €1.4m by @eraneuron.bsky.social to research causes and treatments for #NeuropathicPain. @mwklab.bsky.social @carolineospelt.bsky.social are also chief investigators. @nihrmaudsleybrc.bsky.social www.kcl.ac.uk/news/interna...

We are hiring a postdoc! If you love culturing neurons and are stellar at electrophysiological characterisation and imaging of sensory neurons, then come and work with us on this cool multi-lab project!🧑‍🎓 👩‍🎓 my.corehr.com/pls/uoxrecru...

Have you been wondering what the role is of non-neuronal cells in modulating sensory neuron activity? Check out this review from @psalmotoxin.bsky.social et al. in @sfnjournals.bsky.social’s #JNeurosci, one of this week’s #EditorsPick papers chosen by @rpseal.bsky.social bit.ly/3XEp2rE #PRF

With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch Here's our accompanying review! www.jneurosci.org/content/45/4...

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

A new #PainResearch paper from us at @phar.cam.ac.uk 😃 Led by Luke Paine from the Bulmer Lab, supported by @javimmunopain.bsky.social & others, & it’s all about acid; not the hallucinogenic kind, but rather H+ www.cmghjournal.org/article/S235...

🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology! Paper: biorxiv.org/content/10.1... Data: humandrg.painseq.com

🎙️ Carol Ann Remme (Amsterdam UMC) joins #WSCC26 (Feb 4–6, 2026, Grindelwald, CH) to talk about cardiac sodium channels ❤️ and their role in cardiac physiology & disease. 🧠 Abstracts due Nov 2 🔗 sodiumchannelconference2026.org/WELCOME/ #NaV #ionchannels #cardiacphysiology #scienceconference

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

Happy to share our new preprint doi.org/10.1101/2025... We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.

Prof Selina Wray will join us as our careers keynote, sharing her journey from a working class background and part time work through to a professorship, and Dr Carole Torsney, our research keynote, will tell us about her preclinical research on sex & gender disparities in pain.

Coming soon thanks to @ish1789.bsky.social sparc.science/datasets/480. Lots and lots of data!

Stuart Bevan and I are offering an exciting MRC DTP-funded PhD project exploring the mechanisms of pain in Long COVID. Find out more about the project here: 🔗 tinyurl.com/3caseacv Application deadline: 28th October @wolfsonsparc.bsky.social y.social @kingsioppn.bsky.social sioppn.bsky.social

New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..https://www.biorxiv.org/content/10.1101/2025.10.03.680240v1

Great to have this out: wonderful team effort, & nice to build on work from others that had identified the dysregulated osteoarthritis lipidome 😃 #neuroskyence #PainResearch

📊 Want to boost your research skills? Join our 3-day training on Experimental Design and Core Statistics in Cambridge (Dec 8–10). ✅ Free to attend 🙋‍♀️ Open to all career stages 🚆 Travel and accommodation costs reimbursed Apply by October 17th 👉 www.giba-uk.org/training-opp...

We are proud to launch what we think is going to be fantastic opportunity for pain neuroscientists and clinicians to learn the foundations of pain neuroscience

Our NEW working groups support effective collaborations across the UK. Could you help answer one of our first 5️⃣ key research questions? 👉 www.giba-uk.org/working-groups 🙋‍♀️ Ambitious ECRs are invited to co-lead each group. Apply before Friday 10th October.

Congratulations @amapruns.bsky.social and all! Can't wait to dig in to this dataset #PainResearch

If you are UK-based and interested in Gut-Immune-Brain Axis research, do sign up to our GIBA+ network and its working groups! You will get access to lots of new contacts, publication and funding opportunities 🧪🧠🤑 #PainResearch #PainScience #neuroskyence #ImmunoSky

The past two decades have seen a global explosion of research into the gut-immune-brain axis. There is great energy in #Southampton today for our #GIBANetworklaunch. Together, we are building a vibrant and diverse research community to fully realise GIBA's potential. Learn more 👉 www.giba-uk.org

New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub

Thanks to everyone who made #NeuPSIG2025 so great, and to the photographer here who somehow managed to capture everyone (?) at this table

Fancy a #neuroskyence trip to Alicante in December? You can propose yourself to give a talk at the 22nd Christmas Meeting of Alicante's Institute for Neurosciences: in.umh-csic.es/en/communica...

On my way home after an excellent trip. First, I went to Poland to visit @mwklab.bsky.social and give a talk together with @gg9761.bsky.social and Jimena Perez-Sanchez. Next, we all went to Berlin 🚂 to participate in #NeuPSIG where I got to hang out with more of my favorite scientists! #PainResearch

Quick reminder as we head into #NeuPSIG that we have a #PainResearch feed and conferences are the best time to force your friends to join bsky bsky.app/profile/did:...

What better way to get excited for #NeuPSIG2025 than a @utdpaincenter.bsky.social test run of our Machine Learning Workshop? #PainResearch

BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.

If you are preparing your bachelor statistics course and would like to add optional material for students to better understand statistics on a conceptual level (see topics in the screenshot) my free textbook provides a state of the art overview. lakens.github.io/statistical_...

Many congratulations again on this fabulous piece of work! 🎉🥳 Required reading for people in #PainResearch #painscience

We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future! www.nature.com/articles/s41...

Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch

Congrats @amy-lock.bsky.social on another great paper based on your PhD! #PhDSky this should also be of interest to people on #Immunosky #AcademicSky

Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further! www.biorxiv.org/content/10.1... @denklab.bsky.social #fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal

This work is finally online as in-press preview! JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

Happy #Caturday 😺😺😺

Summer nap

Have you checked out the relaunch of PRF? Editors’ picks are selected by rotating editorial board members like @gregscherrer.bsky.social @painresforum.bsky.social

Naked mole-rats exhibit reduced inflammatory pain compared to mice. In a comparative study Lanhui Qiu & @psalmotoxin.bsky.social show that artemin has a conserved role in mice & naked-mole rats by mediating inflammatory pain in dorsal root ganglia (in vitro). link.springer.com/article/10.1...

I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys

A good #PainResearch week for Lanhui Qiu in the lab. After being co-first author on our sphingomyelin paper www.oarsijournal.com/article/S106..., her sole first author paper examining the effects of artemin on mouse vs. naked mole-rat sensory neurons is out 😀 link.springer.com/article/10.1...

Our #PainResearch paper showing that sphingomyelin 34:1 (⬆️ in 🧍osteoarthritis synovial fluid) sensitises 🐁 sensory neurons in vitro & causes pain behaviours + knee-innervating neuronal hyperexcitability in 🐁 in vivo is now out in @oacjournal.bsky.social: shorturl.at/Yii8H Skytorial 👇 #neuroskyence

We have a new preprint ⤵️

The Pain Research Forum has relaunched—built for the global pain research community. Explore curated papers, expert content, and join discussions on The Pain Researcher. Registration is free: painresearchforum.or... #PRF #PainResearch #IASP #OpenScience

Excited to see the new website up and running, such a powerful resource for everyone in #PainResearch 😃

What is meant by ‘trustworthy’ research? Join PRF on 21 July, for the Improving Trust in Clinical Trials webinar and explore how trust in research can be built through practical tools and frameworks: bit.ly/4luQVMS #PainEducation #PainResearch

Are you interested in the gut-immune-brain axis (GIBA)? 🧠🔬 Researchers and stakeholders from all disciplines and backgrounds are invited to join the launch event for our UK GIBA Network+. 📅 Monday 22nd September 📍 Southampton Harbour Hotel Book here: www.eventbrite.co.uk/e/uk-giba-ne...