Angelika Lampert

Angelika Lampert

@lampertlab.bsky.social

sodium channels, pain, stem cell derived nociceptors, electrophysiology, sensory neuron subclasses and translational research. Professor for Neurophysiology at RWTH Aachen, Germany.

828 followers175 following45 posts

Angelika Lampert
@lampertlab.bsky.social

Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.

Oksana Iamshanova@iamshanovao.bsky.social

2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026. 🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others. 💡 Submit abstracts by the 26th of September, 2025: lnkd.in/eDhPUVKd 💻 More info: lnkd.in/eJw9pfMz

Angelika Lampert
@lampertlab.bsky.social

Very happy that our science-literature synergism resulting from the worldwide sodium channel conference #WSCC24 in Grindelwald is now out. Ever thought about how the words you are using to describe your results shape how you approach your science? I hope you enjoy reading our article!

Journal of General Physiology@jgp.org

Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism. New Viewpoint article from Peter Hull @fau.de‬ and Angelika Lampert @lampertlab.bsky.social @rwth.bsky.social: rupress.org/jgp/article/... #VoltageGatedNaChannels #Biophysics #IonChannels

Angelika Lampert
@lampertlab.bsky.social

happening today, Tuesday 29th of April!

Angelika Lampert@lampertlab.bsky.social

It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel

Angelika Lampert reposted

Antonios Pantazis lab
@antoniospantazis.bsky.social

New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan! www.jmcc-online.com/article/S002... 🧵 1/11

jmcc-online.comClinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmiaThe present study aimed to characterize the SCN5A variant I1333V, found in five families with a history of suspected catecholaminergic polymorphic ventricular tachycardia (CPVT). SCN5A encodes the por...

Angelika Lampert reposted

Ted Price
@tedpricethepainguy.bsky.social

Our Center is a great place to work! If you are looking for a lab technician position, please check out our posting!

Center for Advanced Pain Studies@utdpaincenter.bsky.social

📢 We're Hiring! Join Our Team at the Center for Advanced Pain Studies! ✨ CAPS is looking for a research technician. If you are passionate about research and studying chronic pain or migraine, this is your opportunity. 🔗 Learn more and apply: UTD.link/2v7

Angelika Lampert reposted

@denklab
@denklab.bsky.social

Join us in Berlin in September! It is going to be a great meeting for those of you interested in neuropathic pain, itch and related conditions! #Painresearch #PainScience 🧪🧠

International Association for the Study of Pain (IASP)@iasp.bsky.social

Time is Running out! Submit your poster abstract for #NeuPSIG2025 and present at the leading international pain meeting in Berlin this September. Submission Deadline: 3 March bit.ly/40r4Zz5 #PainScience #Neurology

Angelika Lampert
@lampertlab.bsky.social

1/5 Are you interested in the role of Nav1.9 in AP generation? And what do all the other #sodiumchannels do in the nociceptor? In a study led by the MD student Phil Köster in the lab, we performed manual patch clamp on all Navs known to be expressed in sensory neurons. Nav1.1,2,3,5,6,7,8,9.

Journal of General Physiology@jgp.org

Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH #Biophysics #Neuroscience #IonChannels

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Angelika Lampert
@lampertlab.bsky.social

4/5 We model a CMi-fiber (sleeping nociceptor) and an Adelta-fiber. In both, Nav1.9 significantly contributed to the fast upstroke of the AP and also to the shoulder formation. We can also nicely mimic Nav related disease pathology, like erythromelalgia, in the model.

Angelika Lampert
@lampertlab.bsky.social

1/5 Are you interested in the role of Nav1.9 in AP generation? And what do all the other #sodiumchannels do in the nociceptor? In a study led by the MD student Phil Köster in the lab, we performed manual patch clamp on all Navs known to be expressed in sensory neurons. Nav1.1,2,3,5,6,7,8,9.

Journal of General Physiology@jgp.org

Köster, Stiehl, @lampertlab.bsky.social and colleagues characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. https://buff.ly/4hku7gH #Biophysics #Neuroscience #IonChannels

Angelika Lampert
@lampertlab.bsky.social

2/5 We find that – not surprisingly – Nav1.8 activates and inactivates at more depolarized potentials compared to all the other Navs. Nav1.9 – recorded by Enrico Leipold – and Nav1.5 activate at the most hyperpolarized potentials. Nav1.9 has hugh window currents, and prominent persistent currents.

Angelika Lampert reposted

Ted Price
@tedpricethepainguy.bsky.social

and a 3rd BOOM! for today: www.biorxiv.org/content/10.1... Again on VGNaCs. Navs enter the PROTAC era!! Well done Alex Chamessian and @robgereau.bsky.social

biorxiv.orgSmall molecule-mediated targeted protein degradation of voltage-gated sodium channels involved in painThe voltage-gated sodium channels (VGSC) NaV1.8 and NaV1.7 (NaVs) have emerged as promising and high-value targets for the development of novel, non-addictive analgesics to combat the chronic pain epi...
Angelika Lampert
@lampertlab.bsky.social

Thank you Ted! As always quick in catching new papers - this one is actually one i am really excited about. Thread to follow.

Ted Price@tedpricethepainguy.bsky.social

and one more BOOM! for today: rupress.org/jgp/article/... A comprehensive look at VGNaCs in DRG neurons from @lampertlab.bsky.social and colleagues with some interesting new ideas on Nav1.9.

rupress.orgNociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials | Journal of General Physiology | Rockefeller University PressKöster et al. characterize eight sodium channel subtypes relevant to nociception and use a computer model to simulate the response of two types of nocicept

Angelika Lampert reposted

Kate Sadler
@katesadlerphd.bsky.social

check it out! our lab's first review paper is officially in print and was selected as an editor's choice at Pain! fun summary video in this link in case you don't feel like reading🦠💩🐁: journals.lww.com/pain/fulltex...

journals.lww.comMicrobiome contributions to pain: a review of the... : PAINoorganisms and the neuroimmune networks that drive pain in such diseases. More recently, microbiomes both inside and across the surface of the body have been recognized for driving sensory symptoms in...

Angelika Lampert reposted

Ted Price
@tedpricethepainguy.bsky.social

Position at University of New Mexico in Anesthesiology: unm.csod.com/ux/ats/caree... I know that their surgery team has setup human DRG recovery and they are keen on an electrophysiologist who can help them to grow their work in human nociceptor neurobiology.

unm.csod.comTenure Track Assistant Professor of AnesthesiologyThe Department of Anesthesiology and Critical Care Medicine at the University of New Mexico Health Sciences Center in Albuquerque, New Mexico,...

Angelika Lampert reposted

John Wallingford
@jbwallingford.bsky.social

Cool paper (and great resource). I’m especially keen the disconnect between mRNA and protein levels in adult tissues! Pay attention #devbiol, it’ll be the same in embryonic tissues. www.cell.com/cell/fulltex...

cell.comA Quantitative Proteome Map of the Human BodyProteomics analysis across human tissues from the GTeX resource reveals insight into tissue-specific pathways and phenotypes arising from genetic diseases.
Nikolai Slavov@slavov-n.bsky.social

5,562 proteins were found to have tissue-specific enrichment across 32 human tissues. The majority of them (3,088) are enriched at the protein but not RNA level. The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.

Angelika Lampert reposted

corrylab.bsky.social
@corrylab.bsky.social

Excited to start the year with this paper with @elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose. @jgenphysiol.bsky.social @scienceanu.bsky.social #ionchannels hubs.la/Q031spy70

hubs.laDrugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel poreTao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the
Angelika Lampert
@lampertlab.bsky.social

Preprint alert: Using human microneurography protocols in PatchSeq experiments on pig DRGs we identify the molecular identity of human dermal CMi-fibers (sleeping nociceptors). We provide an integrated pig-human-more transcriptomic atlas and identify OSMR and SST as marker, backed by human expts.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Molecular architecture of human dermal sleeping nociceptors https://www.biorxiv.org/content/10.1101/2024.12.20.629638v1

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Angelika Lampert
@lampertlab.bsky.social

Preprint alert: Using human microneurography protocols in PatchSeq experiments on pig DRGs we identify the molecular identity of human dermal CMi-fibers (sleeping nociceptors). We provide an integrated pig-human-more transcriptomic atlas and identify OSMR and SST as marker, backed by human expts.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Molecular architecture of human dermal sleeping nociceptors https://www.biorxiv.org/content/10.1101/2024.12.20.629638v1

Angelika Lampert
@lampertlab.bsky.social

Interesting systemic approach to record spinal cord activity and laser evoked potentials

Birgit Nierula@nierulab.bsky.social

New paper together with @tilmanstephani.bsky.social, @Emma Bailey, @Merve Kaptan, @Lisa-Marie Pohle, @Ulrike Horn, @André Mouraux, @Burkhard Maess, @Arno Villringer, @Vadim Nikulin, and @Falk Eippert. journals.plos.org/plosbiology/... 1/2

journals.plos.orgA multichannel electrophysiological approach to noninvasively and precisely record human spinal cord activityWhilst spinal recording techniques are routinely developed for use in experimental animals, methods to interrogate human spinal cord function are lacking. These authors develop a non-invasive electros...

Angelika Lampert reposted

bioRxiv Biophysics
@biorxiv-biophys.bsky.social

Exploring voltage-gated sodium channel conformations and protein-protein interactions using AlphaFold2 https://www.biorxiv.org/content/10.1101/2024.10.15.618559v1

biorxiv.orgExploring voltage-gated sodium channel conformations and protein-protein interactions using AlphaFold2 https://www.biorxiv.org/content/10.1101/2024.10.15.618559v1 Voltage-gated sodium (NaV) channels are vital regulators of electrical activity in excitable cells,