Ed Emmott

Ed Emmott

@edemmott.bsky.social

#RNA #Virology & single-cell #Proteomics |Professor of Virology & Proteomics/Wellcome CDA fellow in C4pr_liv /livuniISMIB | He/Him | Personal account - lab account: emmottlab@bsky.social Web: emmottlab.org

1.3K followers1.5K following100 posts

Ed Emmott reposted

Emmottlab
@emmottlab.bsky.social

While Ed can’t make #Nido2026, the lab is well-represented by Max Erdmann, and @rebee.bsky.social ! They will be sharing some of the labs findings on coronavirus replication! Catch Max’s talk tomorrow (Wed) at 3:25, and Rebee’s poster C-0036

Ed Emmott
@edemmott.bsky.social

Funded PhD studentship on equine tendon homeostasis/ageing with single-cell proteomics for Oct 2026 start! Open to both vets, and non-vets, though the funder offers an enhanced stipend for vets.

Emmottlab@emmottlab.bsky.social

Funded PhD opportunity! (UK students only due to funder restrictions). Investigating cellular heterogeneity in tendon homeostasis and ageing using single-cell proteomics. Deadline 31st July. Project is a collaboration between the Peffers, Emmott and Thorpe labs on equine tendons. Start Oct 2026.

findaphd.comPhD Programmes, Research Projects & Studentships in the UK & EuropeFindAPhD is a comprehensive guide to PhD studentships and postgraduate research degrees

Ed Emmott reposted

Emmottlab
@emmottlab.bsky.social

In other lab news, Ed was promoted to Professor of Virology & Proteomics. Huge thanks to the team for all their work and support! And to the various mentors and supporters who have helped along the way. We have lots more exciting science coming in the near future!

Ed Emmott reposted

Charlotte Houldcroft
@virologyhouldcroft.bsky.social

John Cohen has done a much tidier write up here, also referencing work in progress by the Oxford Vaccine team, Moderna and Serum Institute of India www.science.org/content/arti...

science.orgVaccine experts debate options to combat outbreak of unusual Ebola strainSmall monkey experiments raise some hopes—and many questions
Charlotte Houldcroft@virologyhouldcroft.bsky.social

We do not currently have a vaccine for Bundibugyo ebolavirus. BUT! There are vaccine candidates that have ben tested in animals and could go forward more quickly to human trials. Eg VesiculoVax doi.org/10.1093/infd... and another VSV-based vaccine journals.plos.org/plosntds/art...

doi.orgA Highly Attenuated Panfilovirus VesiculoVax Vaccine Rapidly Protects Nonhuman Primates Against Marburg Virus and 3 Species of Ebola VirusAbstractBackground. The family Filoviridae consists of several virus members known to cause significant mortality and disease in humans. Among these, Ebola
Ed Emmott
@edemmott.bsky.social

Early bird registration still available! Come join for what is always an excellent and very friendly meeting.

British Society for Proteome Research@ukbspr.bsky.social

We are delighted to inform you that BSPR 2026 will be held at the @ebi.embl.org campus in Cambridge from the 13th to the 15th of July. Make sure to save the data and join us for the a meeting full of great science focused on British & Irish Proteomics. #proteomics #BSPR2026 #massspectrometry

Ed Emmott
@edemmott.bsky.social

New preprint from the lab!

Emmottlab@emmottlab.bsky.social

New preprint! Current T7-based MNV reverse genetics can be performed by co-transfecting plasmids encoding T7 RNA polymerase and vaccinia capping enzymes. We see a further 100-1000-fold boost in titres by incorporating CD300lf-expressing BSR-T7 cells into this system. www.biorxiv.org/content/10.6...

biorxiv.orgbiorxiv.org
Ed Emmott
@edemmott.bsky.social

We have a PhD studentship available!

Emmottlab@emmottlab.bsky.social

Funded PhD studentship (UK students only) available on clinical proteomics, application deadline 22nd March for Oct 2026 start! This project seeks to understand treatment responses to exacerbations experienced by people with CF using proteomics. www.findaphd.com/phds/project...

findaphd.comProteomic Signatures of Treatment Response During Pulmonary Exacerbations in Cystic Fibrosis at University of Liverpool on FindAPhD.comPhD Project - Proteomic Signatures of Treatment Response During Pulmonary Exacerbations in Cystic Fibrosis at University of Liverpool, listed on FindAPhD.com

Ed Emmott reposted

Willem van Schaik
@wvschaik.bsky.social

Update on UKRI funding situation. Summary: it is mostly bad news, and with significant uncertainties around new funding model.

Research Professional News@resprofnews.bsky.social

‘Grave’ concerns over applicant-led funds at UK research councils. www.researchprofessionalnews.com/rr-news-uk-r...

Ed Emmott
@edemmott.bsky.social

New preprint on flavivirus-host interactions with friend and collaborator Armando who spent a couple of months visiting the lab to do the interactomics with us.

Emmottlab@emmottlab.bsky.social

Another new preprint! This time looking at flavivirus NS5 interactions with our collaborator Armando Arias - www.biorxiv.org/content/10.6...

biorxiv.orgMitophagy-related prohibitin 2 is an orthoflavivirus restriction factor targeted for degradation during infectionMitophagy selectively removes depolarised and damaged mitochondria, promoting cell viability. Some members of the Orthoflavivirus genus activate mitophagy to allow extended replication times in a surv...
Ed Emmott
@edemmott.bsky.social

See Markella’s thread for more information on our new scpImaging preprint!

Markella Loi@biomarkella.bsky.social

I’m excited to share our preprint introducing scpImaging, a workflow we developed to improve data quality in single-cell proteomics (SCP) by repurposing the microscopy images generated during cell isolation with the cellenONE platform www.biorxiv.org/content/10.6...

biorxiv.orgSingle-cell phenotypic analysis and multiplet detection through incorporation of microscopy data into cellenONE-based single-cell proteomic data analysisThe reliability of single-cell proteomics (SCP) is intrinsically linked to the fidelity of cell isolation; however, the identification of co-isolated cells (doublets or multiplets) remains a persisten...
Ed Emmott
@edemmott.bsky.social

New preprint. Thread to follow!

Emmottlab@emmottlab.bsky.social

New preprint from the lab, and joint first authors @biomarkella.bsky.social and @stephenholmes.bsky.social! Single-cell phenotypic analysis and multiplet detection through incorporation of microscopy data into cellenONE-based single-cell proteomic data analysis www.biorxiv.org/content/10.6...

biorxiv.orgSingle-cell phenotypic analysis and multiplet detection through incorporation of microscopy data into cellenONE-based single-cell proteomic data analysisThe reliability of single-cell proteomics (SCP) is intrinsically linked to the fidelity of cell isolation; however, the identification of co-isolated cells (doublets or multiplets) remains a persisten...
Ed Emmott
@edemmott.bsky.social

New preprint! More landing soon!

Emmottlab@emmottlab.bsky.social

New preprint: Viral protease-mediated polyprotein processing in human astroviruses Great collaboration with Lulla lab. And the first of @leandroxneves.bsky.social proteolysis stories. More coming soon! www.biorxiv.org/content/10.1...

biorxiv.orgViral protease-mediated polyprotein processing in human astrovirusesPositive-sense RNA viruses often encode large polyproteins that are proteolytically processed by viral and host proteases into functional replication proteins. Astroviruses infect intestinal and neuro...
Ed Emmott
@edemmott.bsky.social

Funded PhD opportunity!

Emmottlab@emmottlab.bsky.social

Funded PhD opportunity through the DiMeN DTP: studying HEV proteolysis. You’ll be primarily based in the Herod lab at Leeds, and work with us on the use of MS-based proteomics to study proteolysis! www.findaphd.com/phds/project...

findaphd.comMRC DiMeN Doctoral Training Partnership: Molecular Regulation of Proteolysis by Hepatitis E Virus as a Basis for Therapeutic Intervention at University of Leeds on FindAPhD.comPhD Project - MRC DiMeN Doctoral Training Partnership: Molecular Regulation of Proteolysis by Hepatitis E Virus as a Basis for Therapeutic Intervention at University of Leeds, listed on FindAPhD.com
Ed Emmott
@edemmott.bsky.social

This was great fun, and excellent questions at the Q & A after the show. Looking forward to sharing the recordings soon.

Ed Emmott@edemmott.bsky.social

The British science festival 2025 has started in Liverpool and @idb-virology.bsky.social and the team are looking forward to welcoming visitors to the Unity theatre this evening for some antiviral roller skating! @antiviral-rskating.bsky.social www.unitytheatreliverpool.co.uk/whats-on/ant...

unitytheatreliverpool.co.ukAntiviral roller skating! | British Science Festival 2025 - Unity TheatreRun time: 18.30 – 19:15 Throwback: it’s summer 2020, lockdowns are looming, you’ve bought yourself a pair of roller skates to cure your boredom… Swoop over to see the Liverpool Roller Birds dance agai...
Ed Emmott
@edemmott.bsky.social

The British science festival 2025 has started in Liverpool and @idb-virology.bsky.social and the team are looking forward to welcoming visitors to the Unity theatre this evening for some antiviral roller skating! @antiviral-rskating.bsky.social www.unitytheatreliverpool.co.uk/whats-on/ant...

unitytheatreliverpool.co.ukAntiviral roller skating! | British Science Festival 2025 - Unity TheatreRun time: 18.30 – 19:15 Throwback: it’s summer 2020, lockdowns are looming, you’ve bought yourself a pair of roller skates to cure your boredom… Swoop over to see the Liverpool Roller Birds dance agai...

Ed Emmott reposted

Dalan Bailey
@dalan-bailey.bsky.social

Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...

biorxiv.orgUnderstanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity.Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...
Ed Emmott
@edemmott.bsky.social

Collaboration with Hazel Stewart and team from Cambridge now published, and congrats to @stephenholmes.bsky.social on a first paper from his PhD!

Emmottlab@emmottlab.bsky.social

New paper: collaboration with Cambridge on EMCV 2B* now published journals.asm.org/doi/10.1128/...

journals.asm.orgEncephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif | mBioEncephalomyocarditis virus (EMCV) infects a range of species, causing economically important reproductive disorders in pigs and encephalitis and myocarditis in rodents. Due to its wide host range, it ...

Ed Emmott reposted

Charlotte Hutchings
@charlh-science.bsky.social

Happy to share an updated workflow for the analysis of subcellular proteomics derived from protein correlation profiling MS data! Super fun to write up everything I’ve learnt working with this type of data. We hope it’ll be helpful for the wider community.⭐️ f1000research.com/articles/14-...

f1000research.comF1000Research Article: An updated Bioconductor workflow for correlation profiling subcellular proteomics.Read the latest article version by Charlotte Hutchings, Thomas Krueger, Oliver M Crook, Laurent Gatto, Kathryn S Lilley, Lisa M Breckels, at F1000Research.
Ed Emmott
@edemmott.bsky.social

Thank you from Roz and myself for everyone who attended and presented at #BSPR2025 and helped make it an amazing conference. Also a big thanks to those behind the scenes who made it happen: James, Phil, Sue, Becki, Kathryn, Matthias, Sarah and many more! Looking forward to #BSPR2026 at Hinxton!