Erin E. Cutts

How does an embryo generate the right cells in the right place? Delighted to share our latest findings on how neural crest cells acquire vagal or trunk identities Spoiler alert: The timing & combination of CDXs preconfigures cell identity & distinct HOX states www.biorxiv.org/content/10.6...

Our latest paper is out! 🎉 We show that the HSV-1 origin binding protein UL9 tethers dsDNA thereby forming intramolecular DNA loops and intermolecular DNA tethers. 🤝 www.nature.com/articles/s41...

Sigh…

Really fun multidisciplinary project with Enrique (Fadri) Martinez-Perez’s lab. Simulations by Punam Rattu, who did her PhD with me at @unisouthampton.bsky.social and is now in @philbiggin.bsky.social’s group here at @oxfordbiochemistry.bsky.social. www.nature.com/articles/s41...

m.youtube.com/watch?v=TzN1...

May the odds be ever in your favour

🚨 1 WEEK remaining until the Abstract Deadline on 22nd March 2026! 🔬 We’re calling all early career researchers to apply as soon as possible to be considered for an oral presentation! 🔗 www.grc.org/single-molec... #biology #biophysics #single-molecule #microscopy #ECR

Super Early Bird deadline Sunday 8 Mar! Save €100 Register for Machines on Genes 2026 ⚙️🧬 Biochemical Society Harden Conference 📍 Heraklion, Crete | 8–11 June 2026 🌊☀️ www.eventsforce.net/biochemsoc/f... Scientific organisers: Lori Passmore, Dana Branzei & Alessandro Costa

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

Structural basis for CTCF-mediated chromatin organization https://www.biorxiv.org/content/10.64898/2026.02.06.704447v1

How is Condensin II activated during mitosis? 🧬 @damlatetiker.bsky.social Samejima et al. uncover how Condensin II autoinhibition is relieved by the mitotic activator M18BP1, and reveal that M18BP1 also forms a composite DNA anchor with the NCAPG2–NCAPH2 subcomplex to stabilize DNA loops in vitro.

🔬 Calling all early-career researchers (ECRs) for the GRS Single Molecule Approaches to Biology! 🌎 Location: Les Diablerets, Switzerland 📆 Save the date: June 27-28, 2026 🔗 More information: www.grc.org/single-molec... #biology #biophysics #single-molecule #microscopy #ECR

Do you have an interest in quantitative microbiology and interdisciplinary research? I'm recruiting a UK PhD student to develop high-throughput ecological screens to help us understand how chemical inputs impact microbial ecosystems: www.findaphd.com/phds/project...

New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

Read our latest work - a comprehensive review on how DNA secondary structures affect replication. Very proud of Adi, Maria and Billie for their monumental effort. They've covered a large body of literature while proposing updated models. Open Access in DNA Repair: doi.org/10.1016/j.dn...

Only a few days left to apply for this PhD opportunity in my lab! More details and how to apply at: www.findaphd.com/phds/project...

This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here www.embopress.org/doi/full/10....

We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...

70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population. pmc.ncbi.nlm.nih.gov/articles/PMC...

The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It… 1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.

I’ve been offline for a while for the reason below. But I’m back in the lab, with more motivation and joy than ever before! The last year has been a wild ride, but everything has worked out brilliantly!

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

It's more important than ever for students and educators to stay informed and proactive. That's why you're invited to our upcoming webinar “The Future of Graduate Education in Biophysics" September 4, 3:30-5:00PM USA Eastern my.biophysics.org/events/calen...

Starting off our NAF 2025 meeting with an introduction of the RSC Nucleic Acids Group's new chair, Marco Di Antonio! An exciting new era for our group begins! 🧬 @diantoniogroup.bsky.social

This is a proper tour de force of integrative structural biology and biochem! (Including from our own @eecutts.bsky.social @mcb-sheffield.bsky.social) so many crucial roles for SLiMs in fundamental cellular processes.

Condensin II activation by M18BP1: Molecular Cell www.cell.com/molecular-ce...

JOB OPENING for biochemist/-physicst 🧑‍🔬: This isn't an official job ad yet. We are looking for a postdoc working on large to high throughout single-molecule FRET on protein structures and dynamics. The project will be run in our lab and co-directed jointly with a team from big pharma/biotech. 1/2

Job Alert 🔊🔊 Looking for your first or next Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential for this post tinyurl.com/2p9rndfy

Looking for a senior lecturer (associate #professor) position in #biochemistry? Come and join our neighbouring department at Uppsala University: www.uu.se/en/about-uu/...

Less than two weeks to go! Thanks for all the donations! www.justgiving.com/team/thalia

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

Fantastic new work on substrate recognition by separase! www.biorxiv.org/content/10.1...

Anyone looking for a PhD: the second deadline of the Yorkshire DTP closes this Friday, the 14th. Get in touch asap if you are interested in working with me on condensin complexes! www.findaphd.com/phds/project...

Deadline for abstract submission (for poster/short talk presentation) extended until March 14 - after that we will open registration for scientific participants without abstracts.

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