Prahathees Eswara

Prahathees Eswara

@eswaralab.bsky.social

Associate Professor at U. South Florida 🌴🌊 | Postdoc - NIH | PhD - U. Houston | Bacterial Cell Biologist πŸ”¬ | he/him www.eswaralab.com

894 followers460 following58 posts

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I am so proud of this work spearheaded by @lilymcknight.bsky.social! In this ~4-year effort, we reveal that the presence of GpsB is crucial for cell wall stress response and antibiotic resistance (via Stk/PknB and VraSR) in S. aureus. See the thread below for more info! #MicroSky #AMR #ProudPI

Lily McKnight@lilymcknight.bsky.social

1/10 I am thrilled to announce my first first-author preprint, now live on bioRxiv! This focuses on my favorite little protein, GpsB, and its ties to fosfomycin resistance through phosphoregulation in S. aureus (a 🧡) www.biorxiv.org/content/10.6...

Prahathees Eswara reposted

FACULTY POSITION: We are seeking an Assistant Professor to join our growing and vibrant Department of Microbiology at Cornell! FOCUS: Using bacteria to address 21st century challenges. (part of a cohort hire in SynBio). *please repost* academicjobsonline.org/ajo/jobs/33098 #MicroSky

academicjobsonline.orgCornell University, Microbiology/CALS Job #AJO33098, WDR-00061962 Assistant Professor - Harnessing the Power of Synthetic Biology, Microbiology/CALS, Cornell University, Ithaca, New York, US

Prahathees Eswara reposted

GpsB is the hardest working protein in Firmicutes (it's a hub that modulates ~10 different cell division & cell wall synthesis proteins), but how can one protein manage all this? Apparently, the answer is phosphorylation. Great new paper by @lilymcknight.bsky.social and @eswaralab.bsky.social

Lily McKnight@lilymcknight.bsky.social

1/10 I am thrilled to announce my first first-author preprint, now live on bioRxiv! This focuses on my favorite little protein, GpsB, and its ties to fosfomycin resistance through phosphoregulation in S. aureus (a 🧡) www.biorxiv.org/content/10.6...

Prahathees Eswara reposted

Prahathees Eswara reposted

We (Biological Sciences at Virginia Tech) are #hiring TWO tenure-track Molecular Microbiology professors! Review of applications starts 1 Nov. I'm happy to answer questions about the department, VT, life in Blacksburg, etc.! More info / to apply: jobs.apply.vt.edu/jobs/assista... πŸ§ͺπŸ‘©β€πŸ”¬πŸ¦  #academicjobs

jobs.apply.vt.eduAssistant/Associate Professor - Blacksburg, Virginia, United StatesJob Description The Department of Biological Sciences in the College of Science at Virginia Tech seeks applicants for two (2) tenure-track research and teaching positions at the Assistant/Associate ...

Prahathees Eswara reposted

the "Mg²⁺ problem" has been known for a long time. For example, in the standard "rich medium" LB (seeπŸ‘‡). now we get to know more about the reasons! #MicroSky

smallthingsconsidered.blogThe LimΒ­iΒ­taΒ­tions of LB Mediumby Hiroshi Nikaido β€” LB medium, also known incorrectly as Luria-Bertani medium, is widely used to grow bacterial cultures, mainly because it is easy to prepare and provides a broad base of nutrien…
Kumaran Ramamurthi@ramamurthilab.bsky.social

Folks have known for years that adding magnesium to media rescues the lethality of deleting many 'essential' genes, but why? @eswaralab.bsky.social and @subtisilly.bsky.social say that free iron builds up in these mutants. Mg2+ mitigates this by redirecting metabolism towards limiting ROS production

Prahathees Eswara reposted

Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early!

Prahathees Eswara reposted

Folks have known for years that adding magnesium to media rescues the lethality of deleting many 'essential' genes, but why? @eswaralab.bsky.social and @subtisilly.bsky.social say that free iron builds up in these mutants. Mg2+ mitigates this by redirecting metabolism towards limiting ROS production

Prahathees Eswara reposted

#MicroSky act fast! Sept 4th is the registration deadline for Midwest Microbial Pathogenesis Conference (MMPC) that will be held in Minneapolis from Sept 25-27 #mmpc2026

MMPC registration & hotel block closes this week! Your to-do list before *September 4*: 1) Register for the meeting! βœ… 2) Reserve your hotel room! βœ… 3) Get your official MMPC t-shirt! βœ… Check off all these tasks here ➑️ mmpc2026.umn.edu See you in Minneapolis! #mmpc2026

Prahathees Eswara reposted

Thrilled to share this insightful work of Asher King @subtisilly.bsky.social and Pilar Horigian @pilarhorigian.bsky.social! #ProudPI #MicroSky #AMR #SubtiWiki In this work, we reveal the *magic* behind the protective effects of magnesium in Bacillus subtilis. Read Asher's 🧡 below for more details.

Prahathees Eswara reposted

Ribosomal RNAs are modified, but why? Zac Park examined a methylated residue on 16S rRNA in #Bacillus subtilis. He says 1) methylation by MraW permits robust translation, & 2) select transcripts evolved stem loops that fine tune the amount of protein produced www.sciencedirect.com/science/arti...

sciencedirect.com16S ribosomal RNA modification drives transcript-specific translation efficiencyBacterial ribosomal RNAs (rRNAs) are decorated with conserved nucleotide modifications, but the functionality of these modifications is often underexp…

Prahathees Eswara reposted

Prahathees Eswara reposted

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

Prahathees Eswara reposted

Biofilm formation in #Bacillus subtilis is thought to precede sporulation, but T. Updegrove says that a subpopulation of sporulating cells triggers other cells to become biofilm formers via an intracellular metabolite (glycerol) repurposed as a signaling molecule (!) www.science.org/doi/10.1126/...

science.orgA metabolite morphogen coordinates multicellular development in Bacillus subtilisCell-cell signaling using a core metabolite repurposed as a developmental cue coordinates bacterial multicellular development.

Prahathees Eswara reposted

Session proposals are open - hope to see you in Chicago!

Simon Roux@simrouxvirus.bsky.social

Session proposals are now open for ASM Microbe 2027 ! asm.org/events/asm-m... If there is a specific topic or speaker you would like to see in Chicago, this is your chance (until Aug 12) ! This is for Micro Symposia and Hub Sessions, but my DMs are open if you have ideas for bigger AEM sessions

Prahathees Eswara reposted

Devastated to report that Brandon Jutras passed away a day or two ago. Brandon earned his PhD with me. He went on to be an Associate Professor at Northwestern University School of Medicine and a super star in Lyme research. A loving husband and father, a sincere friend, and a brilliant scientist πŸ’”

Prahathees Eswara reposted

New pre-print from the lab, about impact of cell wall antibiotics on PG elongation machineries. Any comments and (constructive) criticism are welcome!

bioRxiv Microbiology@biorxiv-microbiol.bsky.social

Differential impact of cell wall antibiotics on the Rod complex and aPBPs in Bacillus subtilis: Insights into the peptidoglycan elongation machineries https://www.biorxiv.org/content/10.64898/2026.07.24.740396v1

Prahathees Eswara reposted

Another chapter of my thesis is out! We asked whether we could pair proteome-wide AlphaFold screening with Tn-seq to identify biologically relevant protein-protein interactions. We identify ClcR (formerly YerH) as a component of the Rod complex in Gram-positive bacteria. www.pnas.org/doi/10.1073/...

pnas.orgA broadly conserved gram-positive lipoprotein regulates cell elongation | PNASThe cell wall peptidoglycan (PG) protects virtually all bacteria from osmotic lysis and specifies cell shape. Synthesis of this exoskeleton is carr...

Prahathees Eswara reposted

What would happen if Darwin, Russell Wallace and Koch walked into a bar? We present our new way to study mycobacteria, employing a macroevolution framework (species not strains). Possibilities are endless!! Thanks to Fernanda Subtil for pushing this. elifesciences.org/articles/101...

elifesciences.orgA macroevolution-inspired approach to reveal novel antibiotic resistance mechanismsUsing macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.

Prahathees Eswara reposted

Today marks 30 years since we identified the apicoplast, a relict plastid in human and animal parasites (PMID 8632819). Apicoplasts are the target of the widely used antimalarial prophylactic doxycycline, which has saved many thousands of malaria infections.

What!? 🧐 I'm not a fan of the new logo nor ASM not being an abbreviation. Imagine that for WHO. Perhaps we should look at the revenue structure and call it the American Society "of" Microbiologists (like our Canadian counterpart). Or GSM for Global Society for Microbiology!

ASM@asm.org

Since 1899, we’ve been known as the American Society for Microbiology, or ASM. We will now be known simply as ASM. We’re introducing a new brand identity that better reflects who we are, where we are headed and what drives us. Explore now: asm.social/2XF ASM. Microbes Make Our World.

Congratulations, Maria and team! 🀩 πŸ‘πŸΎ When we wrap up all the dissertation projects started by @drmariawhite.bsky.social, Dr. White will easily have another 4-5 publications! πŸ’ͺπŸ‘©β€πŸ”¬

Maria BjΓ€rterot-White, PhD.@drmariawhite.bsky.social

Delighted to be able to share my work from my first postdoc in the @krijonas.bsky.social group at Stockholm University. With thanks to my wonderful colleagues and our fantastic collaborators! Here we show an essential role for PolyP during recovery from starvation in Caulobacter.

This news is heartbreaking! I remember Allie's excellent talks at Phages (Madison, WI) and at ASM Microbe last year. We spoke just few months ago regarding collaboration. What an immense loss to the scientific community! πŸ‡ΊπŸ‡Έ πŸ‡«πŸ‡· πŸ‡―πŸ‡² Deepest condolences! πŸ•Š #MicroSky medschool.ucsf.edu/news/remembe...

medschool.ucsf.eduRemembering Allison Williams, PhDWe write with deep sadness to inform you of the passing of our much-loved colleague, Allison Hillary Mckenzie-Forget Williams, PhD, who died two weeks ago after a years-long battle with cancer. We ext...

Prahathees Eswara reposted

Researchers have identified superparamagnetic macrophages in the livers of rock pigeons to be crucial for magnetic sensing. The finding uncovers an unexpected role for immune cells in sensory perception and may fundamentally change our understanding of animal navigation. https://scim.ag/4nTQ3nq

Prahathees Eswara reposted