I am so proud of this work spearheaded by @lilymcknight.bsky.social!
In this ~4-year effort, we reveal that the presence of GpsB is crucial for cell wall stress response and antibiotic resistance (via Stk/PknB and VraSR) in S. aureus.
See the thread below for more info!
#MicroSky#AMR#ProudPI
1/10
I am thrilled to announce my first first-author preprint, now live on bioRxiv! This focuses on my favorite little protein, GpsB, and its ties to fosfomycin resistance through phosphoregulation in S. aureus (a π§΅) www.biorxiv.org/content/10.6...
FACULTY POSITION: We are seeking an Assistant Professor to join our growing and vibrant Department of Microbiology at Cornell!
FOCUS: Using bacteria to address 21st century challenges. (part of a cohort hire in SynBio).
*please repost*
academicjobsonline.org/ajo/jobs/33098#MicroSky
GpsB is the hardest working protein in Firmicutes (it's a hub that modulates ~10 different cell division & cell wall synthesis proteins), but how can one protein manage all this? Apparently, the answer is phosphorylation. Great new paper by @lilymcknight.bsky.social and @eswaralab.bsky.social
1/10
I am thrilled to announce my first first-author preprint, now live on bioRxiv! This focuses on my favorite little protein, GpsB, and its ties to fosfomycin resistance through phosphoregulation in S. aureus (a π§΅) www.biorxiv.org/content/10.6...
Looking for a faculty position combining research in fundamental cell and molecular biology with therapeutic discovery?
Join our amazing faculty at the @weillinstitute.bsky.social at Cornell University in Ithaca, New York.
academicjobsonline.org/ajo/jobs/32657
Apply by Nov. 15!
Please share!
the "MgΒ²βΊ problem" has been known for a long time. For example, in the standard "rich medium" LB (seeπ).
now we get to know more about the reasons! #MicroSky
Folks have known for years that adding magnesium to media rescues the lethality of deleting many 'essential' genes, but why? @eswaralab.bsky.social and @subtisilly.bsky.social say that free iron builds up in these mutants. Mg2+ mitigates this by redirecting metabolism towards limiting ROS production
Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6β11!
GRS will be on June 5-6, 2027
Weβll likely be oversubscribed, so please apply early!
Folks have known for years that adding magnesium to media rescues the lethality of deleting many 'essential' genes, but why? @eswaralab.bsky.social and @subtisilly.bsky.social say that free iron builds up in these mutants. Mg2+ mitigates this by redirecting metabolism towards limiting ROS production
I am so excited to share my first first-author manuscript regarding the mysterious effects of magnesium in Bacillus subtilis! π§΅β¬οΈ
www.biorxiv.org/content/10.6...#MicroSky
#MicroSky act fast! Sept 4th is the registration deadline for Midwest Microbial Pathogenesis Conference (MMPC) that will be held in Minneapolis from Sept 25-27 #mmpc2026
MMPC registration & hotel block closes this week! Your to-do list before *September 4*:
1) Register for the meeting! β
2) Reserve your hotel room! β
3) Get your official MMPC t-shirt! β
Check off all these tasks here β‘οΈ mmpc2026.umn.edu
See you in Minneapolis! #mmpc2026
Thrilled to share this insightful work of Asher King @subtisilly.bsky.social and Pilar Horigian @pilarhorigian.bsky.social!
#ProudPI#MicroSky#AMR#SubtiWiki
In this work, we reveal the *magic* behind the protective effects of magnesium in Bacillus subtilis. Read Asher's π§΅ below for more details.
I am so excited to share my first first-author manuscript regarding the mysterious effects of magnesium in Bacillus subtilis! π§΅β¬οΈ
www.biorxiv.org/content/10.6...#MicroSky
Ribosomal RNAs are modified, but why? Zac Park examined a methylated residue on 16S rRNA in #Bacillus subtilis. He says 1) methylation by MraW permits robust translation, & 2) select transcripts evolved stem loops that fine tune the amount of protein produced
www.sciencedirect.com/science/arti...
@felixrl.bsky.social told us previously *how* #Staph aureus does orthogonal cell division. In his latest paper he tells us *why*: to arrange cell surface proteins required to form staphylococcal abscess colonies. (Videos S1-S2 are amazing!). π€―
www.cell.com/cell-reports...
Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague!
Full announcement: uchicago.app.box.com/s/ckih9zv3rj...
Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.
Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.
Biofilm formation in #Bacillus subtilis is thought to precede sporulation, but T. Updegrove says that a subpopulation of sporulating cells triggers other cells to become biofilm formers via an intracellular metabolite (glycerol) repurposed as a signaling molecule (!)
www.science.org/doi/10.1126/...
Session proposals are now open for ASM Microbe 2027 ! asm.org/events/asm-m...
If there is a specific topic or speaker you would like to see in Chicago, this is your chance (until Aug 12) ! This is for Micro Symposia and Hub Sessions, but my DMs are open if you have ideas for bigger AEM sessions
Devastated to report that Brandon Jutras passed away a day or two ago.
Brandon earned his PhD with me. He went on to be an Associate Professor at Northwestern University School of Medicine and a super star in Lyme research.
A loving husband and father, a sincere friend, and a brilliant scientist
π
Pls share: U of Washington has an opening for a tenure-track faculty position at the rank of Assistant Professor. This position is expected to specialize in molecular virology or bacteriology.
Here is a link: microbiology.washington.edu/index.php/ne...
Differential impact of cell wall antibiotics on the Rod complex and aPBPs in Bacillus subtilis: Insights into the peptidoglycan elongation machineries https://www.biorxiv.org/content/10.64898/2026.07.24.740396v1
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications.
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
π’ We're hiring!
The Department of Microbiology & Cell Biology at Montana State University is hiring an Assistant Professor of Microbiology. We welcome applicants working in microbial pathogenesis, immunology, genetics, microbial evolution, and related areas. Apply:
jobs.montana.edu/postings/52009
Who would've thought YjlC-Ndh will be a hot topic in 2026!?! π₯
Here is our preprint (mostly genetics):
pubmed.ncbi.nlm.nih.gov/41928947/
Shedding light on YfhS and YjlC: novel effectors of the NADH dehydrogenase activity of the electron transport chain in Bacillus subtilis
#MicroSky#SubtiWiki
Based on our findings, we suggest renaming YfhS as *MonA* for modulator of Ndh activity and YjlC as *LisA* for membrane lipid-associated ETC scaffold-adapter of Ndh.
Here are two more (mostly structural biology):
(i) www.biorxiv.org/content/10.6...
Quinone-transporting filaments extend the respiratory chain of Gram positive bacteria
(ii) pubmed.ncbi.nlm.nih.gov/42315832/
A Bacillales-specific tubular scaffold essential for NADH dehydrogenase activity
Another chapter of my thesis is out! We asked whether we could pair proteome-wide AlphaFold screening with Tn-seq to identify biologically relevant protein-protein interactions. We identify ClcR (formerly YerH) as a component of the Rod complex in Gram-positive bacteria. www.pnas.org/doi/10.1073/...
Our Dept of Microbiology & Immunology @Geisel School of Medicine @Dartmouth has an opening for an Assistant Professor. Looking for programs bridging multiple areas in Micro & Immuno. A great place to be!
Programs: www.M2P2.orgwww.dartmouthbiofilm.org
Job ad: apply.interfolio.com/187637
EMBO Symposium alert:
Save the date: 9β12 March 2027
Join us in scenic Heidelberg for this unique meeting, covering everything about drug resistance and tolerance.
Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer www.embl.org/about/info/c...
What would happen if Darwin, Russell Wallace and Koch walked into a bar?
We present our new way to study mycobacteria, employing a macroevolution framework (species not strains). Possibilities are endless!! Thanks to Fernanda Subtil for pushing this.
elifesciences.org/articles/101...
Today marks 30 years since we identified the apicoplast, a relict plastid in human and animal parasites (PMID 8632819). Apicoplasts are the target of the widely used antimalarial prophylactic doxycycline, which has saved many thousands of malaria infections.
What!? π§
I'm not a fan of the new logo nor ASM not being an abbreviation. Imagine that for WHO.
Perhaps we should look at the revenue structure and call it the American Society "of" Microbiologists (like our Canadian counterpart).
Or GSM for Global Society for Microbiology!
Since 1899, weβve been known as the American Society for Microbiology, or ASM. We will now be known simply as ASM. Weβre introducing a new brand identity that better reflects who we are, where we are headed and what drives us. Explore now: asm.social/2XF
ASM. Microbes Make Our World.
@agnese75.bsky.social's work is out. She shows that under iron starvation M. tuberculosis splits flux through the Krebs cycle and secretes metabolites, akin of fermentation. Why is this important? Metabolic flexibility is what makes it so hard to kill in vivo.
elifesciences.org/reviewed-pre...
Delighted to be able to share my work from my first postdoc in the @krijonas.bsky.social group at Stockholm University. With thanks to my wonderful colleagues and our fantastic collaborators! Here we show an essential role for PolyP during recovery from starvation in Caulobacter.
Bacterial transmembrane proteins usually localize inside the cell by "finding" a pre-localized protein, but how did the 1st protein get there? @vanipande.bsky.social found a protein in #B.subtilis that localizes by recognizing a *lipid* localization cue. #Microskywww.biorxiv.org/content/10.6...
This news is heartbreaking!
I remember Allie's excellent talks at Phages (Madison, WI) and at ASM Microbe last year. We spoke just few months ago regarding collaboration.
What an immense loss to the scientific community!
πΊπΈ π«π· π―π²
Deepest condolences! π
#MicroSkymedschool.ucsf.edu/news/remembe...
Researchers have identified superparamagnetic macrophages in the livers of rock pigeons to be crucial for magnetic sensing. The finding uncovers an unexpected role for immune cells in sensory perception and may fundamentally change our understanding of animal navigation.
https://scim.ag/4nTQ3nq
Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)!
The Pacific Northwest is an awesome place to live and do science π§ͺπ¦ . Join us!
apply.interfolio.com/185622
Applications due 8/1.
New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread π§΅
www.biorxiv.org/content/10.6...
We are hiring! Focus is on colleagues interested in protein homeostasis and human disease. Priority reviewing starts mid-June and will continue on a rolling basis. Here is the ad, hit me up if you have questions! careers.umass.edu/jobs/assista...