Edward Wallace

New preprint drop! I think this fun little story on Berkson's paradox will become essential reading for computational biology/genomics, where I think it commonly occurs but is poorly known. www.biorxiv.org/content/10.6...

Call for a group leader in Evolutionary Biology The IGFL @igflyon.bsky.social in Lyon, France, is recruiting a group leader in Evolutionary Biology. An exciting place for exploring the interfaces of evolution with physiology and development. #EvolBiol #ecoevo #evodevo tinyurl.com/evolbiol

Recently, @gladfelterlab.bsky.social said to me: "You may think you're done with condensates but condensates are not done with you." Amy, you are so right. @dadrummond.art has not yet been reached for comment.

When I set up the #RNAbiology list on bluesky, I didn't expect that it would gift all the weird things people say about ribosomes. Public engagement with science I guess?

it made me really happy when i learned that the way mutation ultimately creates new proteins is that it just randomly activates or inactivates parts of dna that start coding and your cellular machinery is like guess we makin 🟡 now. does 🟡 do anything. idk. guess we'll find out if we die

Postdoctoral position available! Help us to understand how fungi cause disease, by bringing data-driven engineering biology and cool fluorescent protein tools into fungal pathogens. Details: ewallace.github.io/news/postdoc... Please share!

Yeast colleagues: any idea what @zymoresearch.bsky.social do in their frozen yeast transformation kit for or instead of carrier DNA? zymoresearch.eu/products/fro... Kit looks great and is highly cited, I'm wondering about publicly available info ideally that I can cite in a review paper.

Bunsen burners limitations in aseptic technique! Data-driven evidence here in a neat and careful study For what it's worth, the senior author Hannah Gavin is a lovely human who I used to occasionally play music with in Chicago.

Postdoc/staff scientist/ in computational biology and evolutionary genetics? Alex Cope is very good. I've collaborated with him for years. First author publications, all technically great, some in glam journals. A great team player and nice guy too. scholar.google.com/citations?us...

Postdoc/staff scientist/ in computational biology and evolutionary genetics? Alex Cope is very good. I've collaborated with him for years. First author publications, all technically great, some in glam journals. A great team player and nice guy too. scholar.google.com/citations?us...

Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41...

Yes, I've done this. It's always a delight to work with SGD.

Where are we at on acceptable abbreviations for fluorescent proteins? Like, GFP for green fluorescent protein sure, but is mNG for mNeonGreen too much? Etc? Your strongest opinions and arguments invited.

What's the state of genomes that report on early animal / holozoan evolution? A student project in my lab on evolution of RNA-binding proteins is testing the hypothesis of a gene duplication in early metazoa, we want to look for homologs in in holozoa beyond Monosiga. @jlsteenwyk.bsky.social ?

I worked for UKRI for seven years and in my experience, the short timescales were 100% because of delays in central government. Usually because of delays in sign off by a minister; in the worst cases, due to number 10 comms teams insisting we hold back so the PM could announce it or whatever. 1/3

Save the date : Seminar by Edward Wallace from the University of Edinburgh on Tuesday 12th May at 11h @ewjwallace.bsky.social @edinburgh-uni.bsky.social

I am learning a lot from this debate about the last eukaryotic common ancestor. It's thought-provoking to have competing hypotheses and perspectives argued out there in the open. Here, the two arguments are internally consistent, yet different conclusions... so where's the wrong assumption?

Today's @gautamdey.bsky.social seminar on Evolutionary Cell Biology is mind-blowing in so many ways. Dinoflagellates don't have histones!?!?! And BEAUTIFUL microscopy.

We are hiring a postdoctoral researcher to investigate ribosome hibernation and activation in microsporidia using confocal microscopy, soft X-ray tomography, cryo-electron tomography, and omics approaches. If you are interested, apply here: jobs.exeter.ac.uk/hrpr_webrecr...

Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings!

Ugh...

Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...

Wonderful talk by the legendary Jane Richardson today on validation of #cryoEM and #xray protein structures as part of the S2C2 modeling and validation workshop at SLAC. I continue to be amazed by how deeply she understands macromolecular geometry.

We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....

We had a great fungal minisymposium yesterday @edinburghbiology.bsky.social - really exciting to see the critical mass of fungal researchers here coming together. Next one January or February TBA: Email me to be added to the email list!

Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.

Translon: a single term for translated regions. #Translation @natmethods.nature.com

Pro tip for getting your data into SGD and other knowledgebases: don't hide the data in the supplemental info in PDF format. Put it in Excel with stable identifiers like SGDIDs and systematic_names (ex. YFL039C) in addition to gene names. #yeast #modelOrganism #getYourDataOutGetCited

New preprint! This work is Gabriela Fior Ribeiro's second first-author manuscript, @logantom.bsky.social's first manuscript, and is the culmination of our long-standing collaboration with @ewjwallace.bsky.social's group at University of Edinburgh. www.biorxiv.org/content/10.1...

bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏

V happy with paperpile as a reference manager. Thanks @dadrummond.bsky.social for that recommentation.

I NEED to tell you the story of Tae Heung “William” Kim. He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease. He's a *legal permanent resident* of the United States. And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.

Absolutely loving the random ribosome dreams that appear on the #RNAbiology feed.

Wellcome to bluesky @edinburghbiology.bsky.social - Edinburgh School of Biological Sciences! This feed collects the SBS folks on bluesky who I know about: bsky.app/profile/ewjw...

wellcome.org/news/can-bio...

It’s actually even worse: they show it as a gel, which is pure fluorescence units, but a BioAnalyzes records as the molecules pass a single point sensor and critically _fails to normalize for different molecule speeds_ This results in a near-logarithmic overcounting of large molecules!

THERE ARE TRANSMEMBRANE RNAs NOW?!?!?!? rnajournal.cshlp.org/content/31/8...