Frank Harrell

Frank Harrell

@f2harrell.bsky.social

Professor of Biostatistics Vanderbilt University School of Medicine Consultant, clinical trials/drug development https://hbiostat.org https://fharrell.com

7.9K followers148 following1.5K posts

Frank Harrell reposted

Replying to @mattansb.msbstats.info

IMO simulation based power analysis is the gold standard here -- not because it's better or more accurate (though often...), but because doing it requires knowing enough about the phenomenon you're studying to be able to plug in values that are even remotely reasonable in the first place!

I've updated simulations of performance of various methods for estimating S(t|x) vs. continuous x with right censoring. The new loess method is a winner. fharrell.com/post/kmove #Statistics

fharrell.comMinimal-Assumption Estimation of Survival Probability vs. a Continuous Variable – Statistical ThinkingThere is no straightforward nonparametric smoother for estimating a smooth relationship between a continuous variable and the probability of survival past a fixed time when censoring is present. Sever...
Frank Harrell@f2harrell.bsky.social

Spearheaded by David van Klaveren & with co-authors Peter Austin, Patrick Serruys, @benvancalster.bsky.social our new article in Stat in Med provides a minimal-assumption way to estimate the relationship between survival probability and a continuous variable: onlinelibrary.wiley.com/doi/10.1002/...

Frank Harrell reposted

Frank Harrell reposted

Could be a game changer for diverging color palettes

David Aerne@meodai.color.pizza

CuspHanger 0.4.0 gives you control over the lightness steps, in the form of a bezier curve or any other function. meodai.github.io/cusphanger/

Frank Harrell reposted

Investigative records paint the picture of a professor who took financial and personal advantage of his students for years – from manipulating them into paying him rent to making them clean up after his dog – and grew vengeful when they spoke out about his alleged crimes.

retractionwatch.comTennessee researcher heads to court amid claims of theft, forgery and revengeIn May 2025, Tennessee authorities were preparing to arrest a university math professor for allegedly soliciting university donations from his students and pocketing the money.  Middle Tenness…

I've been going back and forth between the Zed and Cot editors and have found that I prefer Cot for most things. For the one language I needed syntax highlighting for (Typst) that was not built-in to Cot, Claude quickly wrote the Cot plug-in needed.

Frank Harrell@f2harrell.bsky.social

The best editors I've found are Zed and Cot Editor

Frank Harrell reposted

Nice paper about ordinal regression and why computing sample means on ordinal data is usually a good idea. #StatsSky #Statistics

Solomon Kurz@solomonkurz.bsky.social

At a basic level, I think this depends on what you care about. If you want quick pubs for a grade or a promotion, just do t-tests. If you are interested in your data, learn how to fit and interpret ordinal models.

Frank Harrell reposted

Five researchers at Norway’s national gender incongruence clinic are appealing a university committee’s finding they committed “gross negligence” and scientific misconduct after the group published studies using the medical records of more than 1,000 minors.

retractionwatch.comResearchers appeal misconduct finding over studies of trans youthOslo University Hospital Five researchers at Norway’s national gender incongruence clinic are appealing a university committee’s finding they committed “gross negligence” and scientific misconduct …

Nice to see coverage of Bayes and ethics --

Måns Thulin@mansthulin.bsky.social

Looking for a book that covers both statistics and R programming? Check out my book Modern Statistics with R! Coding, visualisation, regression, ML & more. 📖 Read it for free: www.modernstatisticswithr.com 📚 Get printed copies: tinyurl.com/mswrbook #Rstats #statistics #datascience #machinelearning

Excellent @nathanihoff.bsky.social - not only are doubly robust procedures' confidence intervals not robust but point estimates may not be worth the effort. Hope you can compare w/ flexible semiparametric models, which give further advantages to one-step modeling approaches. fharrell.com/post/cpm

fharrell.comThe Unifying Capabilities of Cumulative Probability Semiparametric Models – Statistical ThinkingOrdinal semiparametric regression models in the cumulative probability model (CPM) family, of which proportional odds, proportional hazards, and probit regression are examples, contain virtually all r...
Nathan Hoffmann@nathanihoff.bsky.social

My paper "Double robust, flexible adjustment methods for causal inference: An overview and an evaluation" is out in Social Science Research. Spoiler: In simulations, double robustness appears less important than flexibility, and OLS does pretty well! 🧵👇 1/7 www.sciencedirect.com/science/arti...

Frank Harrell reposted

Big news! 🎉 𝚖𝚊𝚛𝚐𝚒𝚗𝚊𝚕𝚎𝚏𝚏𝚎𝚌𝚝𝚜 1.0.0 for #Rstats is out. It’s a big number and it feels like a big step. I wrote a blog on the challenges of interpreting statistical models, SPEED, cool new features, the future, and a 5 year package development and writing odyssey. arelbundock.com/posts/margin...

The gold standard for producing PDF documents (especially books and journal articles) has been LaTeX. @typst.app re-engineered the entire process in an incredibly elegant extensible way. On my MacOS LaTeX (TexLive) takes 9.1GB of disk space. Typst takes 43MB. Not a misprint.

Now I starting a new book using Typst. I've gotten all the advanced LaTeX features used in my earlier book translated to Typst setup + functions thanks to Claude. This includes marginal notes, back references, advanced indexing, and messy LaTeX tables. #RStats Sweave/knitr inserts R output.

Frank Harrell reposted

I find it hard to believe that a company like #Google doesn't stick to official names on its maps. They were obscenely quick to respond to the random musings of the tangerine tyrant. Very disappointing

David Colquhoun@davidcolquhoun.bsky.social

Shame on Google -they used to care about accuracy. Now they can't wait to lick the boots of the delusional felon

American Journal of Obstetrics & Gynecology should be ashamed.

Retraction Watch@retractionwatch.com

Ivan Oransky, one of the experts who spoke with ProPublica for this story, said he has encountered other cases where journals failed to retract a study after a university made such a request. “You have a situation where the fox is guarding the henhouse,” he said.

Frank Harrell reposted

A rapidly increasing number of published articles rely on analyses produced via the TriNetX platform. However, TriNetX users don’t get full access to the information in the platform, muddying the truthfulness of any analyses of the data and compromising the integrity statements offered by authors.

retractionwatch.comGuest post: The uncomfortable truth an explosion of papers reveals about authors’ access to datawildpixel/iStock The involvement of independent academic researchers in examining data and conducting analyses is central to producing trustworthy research. Because of this, many journals require a…

1/2 This is cool! The main reason that html is not a complete solution (and why the R tinytable package is also important) are that pdf is required for (1) manuscript submission to journals and book publishers (2) documents sent to government agencies, e.g. #Statistics appendices for FDA. #RStats

2/2 Yihui made two other great points: The dependencies required for gt are embarrassing, and we need to quit using LaTeX in favor of @typst.app . Note that the #RStats tinytable package has NO dependencies and outputs html, LaTeX, and typst.

The more I use @typst.app for producing pdf files (haven't gotten much into html production yet) the more I love it. I'm finishing, with Claude's help, major updates to the #RStats Hmisc and rms packages that add full Typst support.

Frank Harrell reposted

New Blog post: Which Data Repository Should you Use? In light of OSF closing down, I compare Zenodo, Dataverse, ResearchBox, PsychArchive, and local repositories on six important dimensions. If you want to know which to pick: It depends! daniellakens.blogspot.com/2026/08/whic...

daniellakens.blogspot.comWhich Data Repository Should You Use?The Center for Open Science has announced that from November 16, 2026, no new projects can be created on the Open Science Framework. After F...

Frank Harrell reposted

All four books I've co-authored are freely available online for non-commercial use: - Bayesian Workflow at avehtari.github.io/Bayesian-Wor... Links to other three books are in the quoted post 👇 (too many books to fit in one post!)

avehtari.github.ioBayesian Workflow book: Website – Bayesian Workflow bookWebsite for the Bayesian Workflow book by Gelman, Vehtari, McElreath, et al. — case studies, code, and exercises in R and Stan.
Aki Vehtari@avehtari.bsky.social

All three books I've co-authored are freely available online for non-commercial use: - #Bayesian Data Analysis, 3rd ed (aka BDA3) at stat.columbia.edu/~gelman/book/ - #Regression and Other Stories at avehtari.github.io/ROS-Examples/ - Active Statistics at avehtari.github.io/ActiveStatis...

When not assuming a normal distribution is it worthwhile to parametrically fit a distribution? Or better to just go with the empirical cumulative distribution function (ECDF) and its generalization - cumulative prob. ordinal regression? New blog article: fharrell.com/post/ecdf #Statistics #StatsSky

fharrell.comParametric Models vs. Empirical Distributions and Ordinal Regression – Statistical ThinkingA primary goal of this article is to compare the accuracy of empirical cumulative distribution functions (ECDFs) and their logical extensions—cumulative probability ordinal regression models—with that...

Frank Harrell reposted

One R function, orm (in the rms package), will fit every model except when using random effects for paired data. The blrm function in the rmsb package handles that. #RStats #Statistics #StatsSky

Another new blog article, elaborating on ordinal regression within the cumulative probability model family. One general model contains an amazing array of special cases used all the time. Do we need to keep teaching special cases&assuming so much? www.fharrell.com/post/cpm/ #Statistics #StatsSky

fharrell.comThe Unifying Capabilities of Cumulative Probability Semiparametric Models – Statistical ThinkingOrdinal semiparametric regression models in the cumulative probability model (CPM) family, of which proportional odds, proportional hazards, and probit regression are examples, contain virtually all r...

Frank Harrell reposted