Filipe De Vadder

Filipe De Vadder

@filipedevadder.bsky.social

@cnrs.bsky.social researcher at @IGFLyon.bsky.social, working on #microbiota #physiology #nutrition #intestine. I like the gut, beer, metal and rugby.

415 followers472 following243 posts

Filipe De Vadder reposted

Manon Aubry
@manonaubryfr.bsky.social

Regardez cette grenade explosive, tirée par des policiers, exploser au milieu d’un autre groupe de policiers. Regardez la violence de l’explosion et les policiers s’effondrer sous l’effet du souffle, malgré leurs équipements de protection intégraux.

Filipe De Vadder
@filipedevadder.bsky.social

Doctorant•es, c’est votre moment de gloire!

Alexandra Delbot@alexandradelbot.bsky.social

Envoyez moi un MP et on vous donne un numéro pour laisser un petit vocal. La demande est : Que veut dire « la méthode scientifique » pour vous, en une seule phrase ! Toutes les sciences sont les bienvenues 💜 L’émission sera diffusée jeudi, donc on a besoin de RT 🙏🙏🙏 merci et vive la science 🧬

Filipe De Vadder reposted

Pierre Bataille
@pierrebat.cpesr.fr

Voici ce que ça donne en un clin d'oeil (ceci est une société qui ne va pas hyper bien) - merci @vincent-lemire.bsky.social pour les sources

Vincent Lemire@vincent-lemire.bsky.social

⚠️ Emballement répressif contre les lycéens, la preuve en chiffres: • En 2 semaines de mouvement lycéen, 5060 gardes à vue (GAV), dont 4400 mineurs. •⁠ ⁠Gilets jaunes 2018-2019 : 6730 GAV (en un an). •⁠ ⁠Loi Travail 2016 : 890 GAV …

Filipe De Vadder
@filipedevadder.bsky.social

🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.

biorxiv.orgJuvenile protein restriction compresses sexual dimorphism in miceSexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...
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Filipe De Vadder
@filipedevadder.bsky.social

The same goes for the spread around a mean. Under scarcity the females did not simply mature later, they matured far less predictably: the timing went from tightly grouped to scattered. Variability is not noise around the result. Here it was part of the result.

Filipe De Vadder
@filipedevadder.bsky.social

This work was led by two brilliant (former and current) PhD students @ameliejoly.bsky.social and @lucasrebiffe.bsky.social, co-led with @francoisleulier.bsky.social. We're grateful to all colleagues who helped us achieve this milestone. Preprint, data and code are open. Happy to answer questions.

doi.orgData and code for: Juvenile protein restriction compresses sexual dimorphism in miceThis deposit contains the curated wet-lab measurements, the R analysis pipeline, and the supplementary-data build outputs supporting the manuscript "Juvenile protein restriction compresses sexual dimo...
Filipe De Vadder
@filipedevadder.bsky.social

🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.

biorxiv.orgJuvenile protein restriction compresses sexual dimorphism in miceSexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...
View full thread
Filipe De Vadder
@filipedevadder.bsky.social

Here is the part I would like people to take away. Had we studied males only, we would have written: low protein stunts growth. Females only: low protein delays puberty. Both true. Neither is the finding. The finding is the distance between them.

Filipe De Vadder
@filipedevadder.bsky.social

Sex is often handled as a nuisance variable, something to hold constant or to average out. Our results say it is a variable in its own right, and one that responds to the environment. Using both sexes is not a box to tick. It is where the biology is.

Filipe De Vadder
@filipedevadder.bsky.social

🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.

biorxiv.orgJuvenile protein restriction compresses sexual dimorphism in miceSexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...
View full thread
Filipe De Vadder
@filipedevadder.bsky.social

Females do the opposite. They protect their growth and postpone puberty instead, waiting until they reach the right body size. One sex keeps the timetable and pays elsewhere. The other keeps the body and pays in time.

Filipe De Vadder
@filipedevadder.bsky.social

And yet both end up paying in the same place. When we let them breed, the difficulty in both sexes is getting a pregnancy started. Once started, litters are normal. Two opposite strategies, the same wall at the end. For females, it lifts once food returns.

Filipe De Vadder
@filipedevadder.bsky.social

🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.

biorxiv.orgJuvenile protein restriction compresses sexual dimorphism in miceSexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...
View full thread
Filipe De Vadder
@filipedevadder.bsky.social

Is this just testosterone disappearing? We removed the testes at weaning to find out. Part of the liver change does depend on male hormones. The growth and metabolic collapse does not. It happens just the same without testes.

Filipe De Vadder
@filipedevadder.bsky.social

Reproduction goes the other way, and this is where the two sexes clearly part. Males reach puberty on schedule, but their chemical signalling, the scent proteins they put in their urine, goes nearly silent. They mature on time and advertise much less.

Filipe De Vadder
@filipedevadder.bsky.social

🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.

biorxiv.orgJuvenile protein restriction compresses sexual dimorphism in miceSexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...
View full thread
Filipe De Vadder
@filipedevadder.bsky.social

And in the liver, one of the most sex-specific organs in the body, with hundreds of genes read differently in males and females. Under low protein, the male liver drifts toward the female profile. The female liver barely moves.

Filipe De Vadder
@filipedevadder.bsky.social

That asymmetry is the heart of it. The two sexes do not meet in the middle. The male moves and the female holds her ground. Under scarcity, the male is the one that bends. The female pattern looks like the cheaper one to build.

Filipe De Vadder
@filipedevadder.bsky.social

🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.

biorxiv.orgJuvenile protein restriction compresses sexual dimorphism in miceSexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...
View full thread
Filipe De Vadder
@filipedevadder.bsky.social

On a normal diet, males and females separate as they grow. Males end up longer, heavier, with longer bones. On the low-protein diet, the two curves lie on top of each other. The difference between the sexes did not shrink. It never appeared.

Filipe De Vadder
@filipedevadder.bsky.social

The same thing happens for metabolism: how much energy they burn, how they handle sugar, what they store in the liver. Put all of it together and the male and female profiles, normally far apart, end up nearly on top of one another.

Filipe De Vadder
@filipedevadder.bsky.social

🚨PREPRINT ALERT How different are males and females? In physiology we mostly treat that as a fixed property of a species, something to control for. In mice, we found it is not fixed at all. It depends on what the animal ate while growing up.

biorxiv.orgJuvenile protein restriction compresses sexual dimorphism in miceSexual dimorphism is canonically understood as a fixed adult trait, scaled by gonadal hormones at puberty, but whether its magnitude is shaped earlier in life by juvenile nutrition during the post-wea...
Filipe De Vadder
@filipedevadder.bsky.social

The starting point is a human puzzle. Wherever childhood undernutrition is measured, boys are hit harder than girls. It shows up in survey after survey, on every continent. Nobody knows why, and nobody knows when in development it happens.

Filipe De Vadder
@filipedevadder.bsky.social

So we did something simple. We fed young mice a diet where only one thing changed, the amount of protein, from weaning to young adulthood. And we kept males and females side by side at every step, which is still not the default in animal physiology.

Filipe De Vadder reposted

Les Soulèvements de la terre
@lessoulevements.bsky.social

⚠️💦 Aujourd'hui, la bassine de Sainte-Soline nous offre un exemple particulièrement concret de l’absurdité du stockage de l’eau dans des bassines à ciel ouvert et de l'important gâchis d'eau causé par l’évaporation. 🧶⤵️1/9

Filipe De Vadder reposted

Bon Pote
@bonpote.com

Beaucoup de bla-bla et de mensonges sur la lutte anti incendie, donc Bon Pote a analysé les votes par parti depuis 2022 à l’Assemblée nationale. Désormais, vous savez qui se bat vraiment pour les pompiers et notre survie. À partager massivement !

Filipe De Vadder reposted

American Statistical Association History of Statistics
@hos-asa.bsky.social

Few statisticians know that Frank Yates, pioneer of experimental design, is responsible for the annoying practice of indicating 3 tiers of statistical significance by stars (*p ≤ 0.05, **p ≤0.01, ***p ≤ 0.001). He soon regretted it and “vehemently opposed its unthinking use”. And here we are.

Filipe De Vadder
@filipedevadder.bsky.social

Stop dividing organ weights by body weight. Ratios don't control for body size. They can create fake effects AND hide real ones. The stats literature has known this for decades. We built a free tool to fix it. 🧵

View full thread
Filipe De Vadder
@filipedevadder.bsky.social

Idea & prototype: @lucasrebiffe.bsky.social. Built into a real app: Laurent Gilquin. With @francoisleulier.bsky.social & the @igflyon.bsky.social team. 📄 doi.org/10.64898/202... #OpenScience #Rstats #Physiology

doi.orgOrganScaleR: An Open Shiny Tool for Principled Organ-Weight Inference in Mouse PhysiologyBackground: Organ weights are often divided by body weight to report "relative" organ size. Yet ratios usually stay size-dependent and become misleading. We built a simple decision path for size adjus...
Filipe De Vadder
@filipedevadder.bsky.social

Stop dividing organ weights by body weight. Ratios don't control for body size. They can create fake effects AND hide real ones. The stats literature has known this for decades. We built a free tool to fix it. 🧵

Filipe De Vadder
@filipedevadder.bsky.social

How to run it: download from Zenodo, install Docker Desktop (free, it lets any app run identically on any computer), paste one line into your terminal. Opens in your browser. That's it. 🛠️ doi.org/10.5281/zeno...

doi.orgOrganScaleR - Shiny applicationOrganScaleR is a Shiny application that allows users to compare organ weights across groups by properly adjusting for body weight, without using ratios. In particular, the application proposes a causa...

Filipe De Vadder reposted

CLASCHES
@clasches.bsky.social

⚡️ COMMUNIQUÉ - Violences sexistes et sexuelles dans l'enseignement supérieur et la recherche : le CLASCHES à bout de souffle face aux défaillances institutionnelles À retrouver également sur notre site internet : clasches.fr/vss-dans-l-e...

Filipe De Vadder reposted

Nicolas Holzschuch
@nholzschuch.bsky.social

Hommage à Séverine Erhel : une collègue engagée nous quitte brutalement.

bretagne.sgen-cfdt.frUne collègue engagée nous quitte brutalement : hommage à Séverine Erhel - SGEN-CFDT Éducation Formation Recherche Publiques BretagneChercheuse reconnue en psychologie cognitive du numérique, discipline qu’elle a contribué à développer, Séverine Erhel a consacré ses travaux à la compréhension des usages des écrans, des jeux vidéo e...

Filipe De Vadder reposted

Anne Cordier
@annecordier.bsky.social

Un dernier hommage sera rendu à Séverine Erhel,le 18 avril 2026 14h, crematorium de Saint Brieuc. Cérémonie ouverte, mais capacité limitée. Pas de fleurs. Des dons peuvent être réalisés à ses fils dans urne prévue sur place, et ultérieurement. Dons à Asso "Les P'tits Doudous" : lesptitsdoudous.org

lesptitsdoudous.orgNous soutenir - Les P'tits DoudousNous soutenir Particuliers & professionnels Accueil Nous soutenir Vous êtes-un particulier Plusieurs solutions Vous êtes un particulier et vous êtes, vous aussi, sensible à l’amélioration du vécu des ...
Anne Cordier@annecordier.bsky.social

Bonjour à tous.tes Nous avons l'indicible douleur de vous faire part du décès de Séverine Erhel, survenu ce lundi 13 avril 2026 à Rennes. (information diffusée à la demande / avec l'autorisation de la famille)

Filipe De Vadder
@filipedevadder.bsky.social

Mon amie, tu t’en vas sans que j’aie pu te dire au revoir. Je pleure ton absence aujourd’hui et je pense à tes enfants et à tes proches, à qui tu vas tant manquer. Repose en paix, j’ai été heureux de te croiser sur mon chemin.

Anne Cordier@annecordier.bsky.social

Bonjour à tous.tes Nous avons l'indicible douleur de vous faire part du décès de Séverine Erhel, survenu ce lundi 13 avril 2026 à Rennes. (information diffusée à la demande / avec l'autorisation de la famille)

Filipe De Vadder reposted

Audrey Dussutour
@docteur-drey.bsky.social

Rappel: En 2023 le CIR représentait 7,8 milliards d'€ d'argent public...quasi le double du budget cumulé du CNRS, de l'INSERM & de l'INRAE. L'État subventionne plus la recherche privée que ses propres organismes scientifiques. C'est Moche. blogs.mediapart.fr/hendrik-davi... @hendrikdavi.bsky.social

blogs.mediapart.frLe hold-up du CIR : comment l’argent public est accaparé par les grands groupes ?Dans une note de novembre 2025, le ministère de l’Enseignement supérieur et de la Recherche livre un bilan chiffré du Crédit impôt recherche (CIR) pour l’année 2023. L’occasion de revenir sur un disp…
RogueESR@rogueesr.bsky.social

Les dotations aux unités du CNRS sont tombées: cure d'austérité trumpienne pour la recherche fondamentale. Pour la première fois, le budget prévisionnel était déficitaire, de 239 millions € (nous l'avions annoncé). Encore 20 millions de moins demandés par Matignon. rogueesr.fr/wp-content/u...

Filipe De Vadder
@filipedevadder.bsky.social

Classic Motörhead will be shining in the sky. Rest in power, legend.

Rock Music Association@rockmusicassoc.bsky.social

Rock In Peace Phil Campbell, lead guitarist for Motorhead, solo artist and leader of Phil Campbell and the Bastard Sons, featuring his three sons; Todd, Dane and Tyla, now gone to that big gig in the sky. #Bummerversary #Motorhead #PhilCampbell #RockHonorRoll

Filipe De Vadder reposted

Science Magazine
@science.org

In a new Science study, researchers find that some bird species share convergent evolutionary changes in key physiological traits and metabolic genes that enable their high-sugar diets. https://scim.ag/4bgMrpy

scim.agConvergent and lineage-specific genomic changes shape adaptations in sugar-consuming birdsHigh-sugar diets cause human metabolic diseases, yet several bird lineages convergently adapted to feeding on sugar-rich nectar or fruits. We investigated the underlying molecular mechanisms in hummin...

Filipe De Vadder reposted

Alexandra Delbot
@alexandradelbot.bsky.social

Une nouvelle étude montre que couper la communication intestin-cerveau chez la souris réduit la libération de dopamine et la motivation face à la nourriture comme aux drogues. Du plaisir aux additions, tout ne se joue donc pas dans le cerveau.

radiofrance.frLe circuit de la récompense passe aussi par l'intestinUne nouvelle étude montre que couper la communication intestin-cerveau chez la souris réduit la libération de dopamine et la motivation face à la nourriture comme aux drogues. Le plaisir ne serait pas...

Filipe De Vadder reposted

Olivier Tesquet
@oliviertesquet.bsky.social

Intéressant de rappeler que l’an dernier, Yaël Braun-Privet avait initialement refusé une minute de silence en la mémoire d’Aboubakar Cissé, poignardé à 57 reprises alors qu’il priait dans une mosquée, au motif que l’hémicycle n’honorait plus « les cas individuels ». www.humanite.fr/politique/br...

LCP-Assemblée nationale@lcp.fr

🔴🏛️ [INFO LCP] Mort de Quentin Deranque à Lyon : l'Assemblée nationale observera une minute de silence cet après-midi en ouverture de la séance de questions au gouvernement (sources parlementaires). #DirectAN

Filipe De Vadder reposted

IGFL
@igflyon.bsky.social

L’IGFL recrute un•e Professeur•e des Universités en biologie moléculaire (CNU 64), UCBL Lyon 1. Enseignement L2-M2 (Biochimie et Biologie Moléculaire) + projet en biologie moléculaire des eucaryotes au sein de l’IGFL. Détails: shorturl.at/K5Dno #Recrutement #BiologieMoleculaire

Filipe De Vadder
@filipedevadder.bsky.social

Petit exercice du dimanche: j’ai voulu soumettre à ChatGPT les questions de l’examen d’arbitre stagiaire de rugby. Des situations pas toujours évidentes mais claires à arbitrer. Résultat: sur 10 questions, il s’est planté dans 7 questions. Et après on va me dire que GPT 5.2 a le niveau d’un PhD?

Filipe De Vadder reposted

Anne Chevallereau
@annechevallereau.bsky.social

Un poste de Maître de Conférence est ouvert pour rejoindre notre unité à Lyon ! Possibilité de rejoindre mon équipe pour travailler sur: - caractérisation des mécanismes de défense anti-phage - transfert horizontal et interactions entre éléments génétiques mobiles N'hésitez pas à me contacter

MMSB-Lyon@mmsb-lyon.bsky.social

📢 Recrutement d’un(e) Maître(sses) de conférence en Biochimie générale, spécialité bactériologie moléculaire à MMSB 🔬Recherche *Immunité anti-phages *Réponse au stress, modulation de la croissance bactérienne ✉️ christophe.grangeasse@cnrs.fr 📚Enseignement : Université Lyon I ✉️ patrice.gouet@ibcp.fr

Filipe De Vadder reposted

IGFL
@igflyon.bsky.social

IGFL external seminar Birds keep losing their penises, repeatedly. Not by chance. Anamaria Necsulea (LBBE Lyon) shows how changes in gene regulation and non-coding DNA drive convergent developmental loss of the male phallus across avian evolution.

Filipe De Vadder reposted

François Leulier
@francoisleulier.bsky.social

Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social journals.biologists.com/dev/article/... Review process via @reviewcommons.org and @dev-journal.bsky.social 1/3

journals.biologists.comBacteria-dependent ecdysone lengthens hungry stomachsIntestinal growth restriction in starving Drosophila larvae can be selectively rescued by Lactiplantibacillus plantarum (Lp) bacteria in the gut, but how microbiota promote growth is not well understo...
François Leulier@francoisleulier.bsky.social

Revised refereed preprint: www.biorxiv.org/content/10.1... Revision work lead by @longweibai.bsky.social Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.