IGFL

6-month internship to explore (genome-wide) enhancer-promoter interactions in the crustacean Parhyale – Hosted by the Averof and Ghavi-Helm teams at IGFL Lyon – Early 2027 – Student (any level) with some prior experience in mol biol – Stipend 695 €/month

#ResultatScientifique🔎| Comment les gènes trouvent-ils leur place dans le noyau, et quel rôle cette position joue-t-elle dans leur activité ? ✍️ Samir Merabet 🔬 @igflyon.bsky.social 👋 @cnrs-rhoneauvergne.bsky.social @ensdelyon.bsky.social @inrae-france.bsky.social buff.ly/Si3srFN

A cost-effective method for finding cis-regulatory elements in a large genome (Parhyale, 3.6 Gb), combining info from chromatin accessibility (bulk & single-nucleus ATACseq) and cross-species sequence conservation (low coverage sequencing from 3 additional Parhyale species) Now published in eLife!

Notre dernier article qui revisite le concept de #Decretin ou comment adapter la production des hormones de croissance au regard des entrants protéiques. Travaux de thèse de @longweibai.bsky.social à @igflyon.bsky.social

Latest from the lab in its final form. We revisit the #Decretin concept in the light of growth adaptation to protein intake. PhD work of @longweibai.bsky.social at @igflyon.bsky.social #Drosophila

👀 Une étude parue dans Science Advances impliquant des scientifiques de l'Institut de génomique fonctionnelle de Lyon @igflyon.bsky.social

🔬 Meet Michalis Averof, ZooCELL PI at IGFL @michalis-averof.bsky.social What sparked his interest in EvoDevo? What keeps him curious after all these years? And what does he hope to discover next? 🧵 Read on to get to know Michalis through his own words. #ZooCELL#EvoDevo#genomics#IGFL#MSCA

How do dozens of distinct muscles emerge from the same pool of precursor cells? Our new Science Advances paper uncovers the developmental logic that coordinates myoblast identities to build diverse muscles. 📄 www.science.org/doi/10.1126/... #DevelopmentalBiology #Drosophila #Muscle

🧠 IGFL External seminar | @dulaclab.bsky.social (Harvard/HHMI) deciphers the neural circuits underlying instinctive social behaviors (parenting, mating, aggression) and how the brain drives adaptive behavioral changes during sickness. What a treat! 🧠

Only few days left to apply! This event is relevant both for wet lab biologists who want to learn more about spatial OMICs and get initiated to data analysis and for bioinformaticians who want to learn about the latests developments in spatial OMICs.

Very proud to host the great one and only Catherine Dulac @dulaclab.bsky.social at IGFL, @igflyon.bsky.social @ensdelyon.bsky.social, on June 1st 2026! I am all excited like a fan can be when meeting one of her idols 😱. Don't hesitate to join if you're in Lyon that day 🧠

These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9

In animals with large genomes, finding cis-regulatory elements can be very challenging. Enhancers can be located tens/hundreds of kb away from their target promoters. We face this challenge in Parhyale, with >3 Gbp genome. We just published a preprint describing how we are tackling this problem. /1

L’IGFL recrute un•e Professeur•e des Universités en biologie moléculaire (CNU 64), UCBL Lyon 1. Enseignement L2-M2 (Biochimie et Biologie Moléculaire) + projet en biologie moléculaire des eucaryotes au sein de l’IGFL. Détails: shorturl.at/K5Dno #Recrutement #BiologieMoleculaire

Un poste de Professeur des Universités va être ouvert lors de la campagne d’emploi 2026 à l’université Claude Bernard Lyon1 - Profil Recherche : Biologie Moléculaire des Eucaryotes. Profil Enseignement: Biologie Moléculaire. Profil ci-joint. Merci de diffuser dans vos réseaux.

Such a pleasant moment listening to the original science from @audeber.bsky.social today at @igflyon.bsky.social @ensdelyon.bsky.social. Out of the box ideas, Outstanding tools, Out of my comfort zone… Totally great!

Bacteria-dependent ecdysone lengthens hungry stomachs This Research Highlight showcases work from Longwei Bai (@longweibai.bsky.social), François Leulier (@francoisleulier.bsky.social) and colleagues at @igflyon.bsky.social journals.biologists.com/dev/article/...

IGFL external seminar Birds keep losing their penises, repeatedly. Not by chance. Anamaria Necsulea (LBBE Lyon) shows how changes in gene regulation and non-coding DNA drive convergent developmental loss of the male phallus across avian evolution.

Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social journals.biologists.com/dev/article/... Review process via @reviewcommons.org and @dev-journal.bsky.social 1/3

#ResultatScientifique🔎| Et si le microbiote intestinal pouvait agir comme un régulateur hormonal pour lutter contre la malnutrition ? ✍️ @francoisleulier.bsky.social 🤝 @cnrs-rhoneauvergne.bsky.social @igflyon.bsky.social @ensdelyon.bsky.social 📕 @dev-journal.bsky.social ▶️ buff.ly/R1VJvDm

Plus que quelques jours pour candidater. Rejoignez-nous!

Amazing to have @alainchedotal.bsky.social with us today @igflyon.bsky.social in front of a full room of people from all over the @ensdelyon.bsky.social campus! Very happy start of 2026 🤯

Very very excited to have Elly Tanaka from @imbavienna.bsky.social for our external seminar series @igflyon.bsky.social! Thanks Eglantine Heude for hosting 🤯

Mobilité interne CNRS : l’IGFL recrute un·e assistant·e ingé pour renforcer ses travaux sur modèles aquatiques et biologie cellulaire. Environnement technologique solide, missions variées recherche/élevages. Candidatures jusqu’au 15/01/2026. emploi.cnrs.fr/Offres/MOBIN...

Very proud to have defended my HDR (« Habilitation à diriger les recherches ») at @ensdelyon.bsky.social. Many thanks to the jury for their constructive feedbacks @clairewyart.bsky.social @francoisleulier.bsky.social @FlorenceRuggiero @PaulineSpéder @stemdevevo.bsky.social @OlivierRaineteau!

It's done! I am now a PhD for real! I defended my PhD thesis last week and what an incredible day it was. I am very grateful to all the members of @igflyon.bsky.social who made these last 4 years and 8 months so memorable. I will cherish all these memories 😊

What are these? You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social see doi.org/10.1101/2024... 🧵

When the clock’s feedback loop breaks, chromatin keeps ticking 🕒 Work from @clocklab-igfl.bsky.social reveals how H3.3-linked PBAF/cBAF shifts sustain BMAL1 activity and reshape circadian chromatine, linking epigenetics to metabolic and ageing control. 🔗 nature.com/articles/s41467-025-64045-2

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by @mmasoura.bsky.social, to find out! www.biorxiv.org/content/10.1...

📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH

Our new study, just accepted in the Journal of the Endocrine Society 👉 doi.org/10.1210/jend... We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.

Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale apply here: www.averof-lab.org/pages/tracman 1/3

Comme tous les ans, l’IGFL accueillera la fête de la science la semaine prochaine. Le public général est bienvenu le samedi 4 octobre. Nous espérons vous voir nombreux! www.ens-lyon.fr/indexation/a...

Ces travaux impliquent l'Institut de génomique fonctionnelle de Lyon. @igflyon.bsky.social 👏

So happy to have Dafni @drosostalis.bsky.social at @igflyon.bsky.social today, for an exciting fly physiology talk! “Mind the gut”!

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

Ces travaux impliquent notamment des scientifiques de l' @igflyon.bsky.social 👏 cc @ensdelyon.bsky.social

Now available in its final form @narjournal.bsky.social ! doi.org/10.1093/nar/... Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.

Excited to host Jean Livet (Institut de la Vision) at IGFL Lyon on June 30th! He’ll share how multicolor labeling and large-volume microscopy reveal the topography and topology of central sensory circuits. A must for connectomics fans! 🧠🔬✨

🦋 Butterflies and beyond! Steven Van Belleghem is now at IGFL revealing how genomes evolve into pangenomes, shaping adaptation and gene regulation in butterflies and Daphnia. Don’t miss this dive into the mysteries of evolution! #EvolutionaryGenomics

🧬 From genomes to pangenomes to adaptation! Join us June 2 at 11am in Salle des Thèses (IGFL) for Steven Van Belleghem’s talk on how structural genome variation and regulatory elements drive evolution—featuring butterflies, beetles, and Daphnia. 🦋🪲🦐

Live now at IGFL: Laure Bally-Cuif (Institut Pasteur) is sharing her fascinating work on the heterogeneity of adult neural stem cells. A deep dive into brain plasticity in action! #Neuroscience #IGFL #StemCells @zenlabpasteur.bsky.social

Congrats to Dr. Laurie Nemoz Billet for earning an Accessit 2025 from @sfbd.bsky.social for her thesis on the role of the ECM in motor nerve development and regeneration in zebrafish! A brilliant contribution to the field. Read more: www.pnas.org/doi/10.1073/... 🎉

🧠 Seminar alert! Laure Bally-Cuif (Pasteur Institute) will present: "Individual cell heterogeneities and population dynamics for adult neural stem cell maintenance" She will show how neural stem cell sub-populations sustain neurogenesis in zebrafish. 📅 05/05/25, 11am, Salle Condorcet ENS Lyon

Time to go mad! Thank you @zaycha.bsky.social for inviting @mads100tist.bsky.social for exciting science on somatosensory neuron diversity.

IGFL will be going mad next Monday, when we host @mads100tist.bsky.social, directly from Basel! We are looking forward to hearing an exciting talk!

Today BioSymposium of the 4 research units at @ensdelyon.bsky.social Great mix of PI and Doc/Postdoc presentations and posters with some live musics tonight @igflyon.bsky.social @lbmcinlyon.bsky.social @ciri-lyon.bsky.social and RDP (not yet on Bluesky I think)

Very excited to host the one and only @mads100tist.bsky.social at @igflyon.bsky.social in Lyon on April 7th! Don't hesitate to pass by for his talk if you're in the city, it promises to be a real treat!

Guest lecture today on Drosophila brain metabolism. Exciting results by Prof. Stefanie Schirmeier from TU Dresden.

Seminar alert! 🧠🔬 Prof. Stefanie Schirmeier (TU Dresden) presents "Metabolic flexibility of the Drosophila nervous system" on March 17th, 11 am at Salle Condorcet. Explore glial cells & adaptive metabolism! #Neuroscience #Metabolism