Although hundreds of viral transcriptional regulators (vTRs) have been identified, we know little about the host pathways they rewire to promote replication and persistence or their mechanisms of action. In our new paper, we addressed this gap across human viruses. 🧵 www.nature.com/articles/s41...
Juan Fuxman Bass
Juan Fuxman Bass
@fuxmanlab.bsky.social
Associate professor at Boston University | systems biology, gene regulation, viral gene expression 🏳️🌈🇦🇷
590 followers535 following36 posts
Together, our results show extensive diversity in how vTRs control host transcription. This work was lead by @jaice-rottenberg.bsky.social and an amazing team of collaborators.
Although hundreds of viral transcriptional regulators (vTRs) have been identified, we know little about the host pathways they rewire to promote replication and persistence or their mechanisms of action. In our new paper, we addressed this gap across human viruses. 🧵 www.nature.com/articles/s41...
Although hundreds of viral transcriptional regulators (vTRs) have been identified, we know little about the host pathways they rewire to promote replication and persistence or their mechanisms of action. In our new paper, we addressed this gap across human viruses. 🧵 www.nature.com/articles/s41...
We systematically characterized 95 vTRs from 31 viruses, integrating transcriptomics, protein-DNA and protein-protein interaction assays, and measurements of transcriptional activity. We found extensive effects on immune signaling, cell cycle, apoptosis, DNA damage/repair, signaling, and metabolism.
Amazing work! Glad to have contributed to this groundbreaking study!
Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.
Excited to share this collaborative review with @dsegre.bsky.social and @devmoy.bsky.social. We discuss common issues with context-specific genome-scale metabolic network models and provide recommendation for future model development.
Just published @cp-trendsbiotech: Flux sampling and context-specific genome-scale metabolic models for biotechnological applications: www.cell.com/trends/biote... by @devmoy, with @fuxmanlab
Exited to share our recent work on viral cis-regulatory elements in collaboration with @tewhey.bsky.social! We identified >2000 CREs across the genomes of 27 human-infecting dsDNA viruses from the Herpesvirus, Adenovirus, Papillomavirus, and Polyomavirus families. www.biorxiv.org/content/10.1... 1/8
Exited to share our recent work on viral cis-regulatory elements in collaboration with @tewhey.bsky.social! We identified >2000 CREs across the genomes of 27 human-infecting dsDNA viruses from the Herpesvirus, Adenovirus, Papillomavirus, and Polyomavirus families. www.biorxiv.org/content/10.1... 1/8
Exited to share our recent work on viral cis-regulatory elements in collaboration with @tewhey.bsky.social! We identified >2000 CREs across the genomes of 27 human-infecting dsDNA viruses from the Herpesvirus, Adenovirus, Papillomavirus, and Polyomavirus families. www.biorxiv.org/content/10.1... 1/8
Exited to share our recent work on viral cis-regulatory elements in collaboration with @tewhey.bsky.social! We identified >2000 CREs across the genomes of 27 human-infecting dsDNA viruses from the Herpesvirus, Adenovirus, Papillomavirus, and Polyomavirus families. www.biorxiv.org/content/10.1... 1/8
Juan Fuxman Bass reposted
Exited to share our recent work on TF isoforms! Amazing work by @kaiamattioli.bsky.social Luke Lambourne and Clarissa Santoso and many other collaborators.
our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
WHERE WILL YOU BE ON MARCH 7TH!? Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one! #standupforscience2025
Juan Fuxman Bass reposted
We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country. This Friday, where will you be? standupforscience2025.org
Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
Juan Fuxman Bass reposted
NIH cuts billions of dollars in biomedical funding, effective immediately. The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease. www.washingtonpost.com/health/2025/...
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