Rob Klose

In case you didn't know: we are acting as guest editors of this special collection on TEs and Development for Mobile DNA. It would be amazing if you could share with relevant researchers 🙏 link.springer.com/collections/...

Congratulations to Manu Hegde, Group Leader & Joint Head @cellbiol-mrclmb.bsky.social who has been selected to deliver the Karl Friedrich Bonhoeffer Award Lecture by @mpi-nat.bsky.social. Click here to read more about Manu’s research: mrclmb.ac.uk/news-events/... #LMBNews

🚨Preprint from our lab🚨 How and when did TADs emerge during evolution? 🐁🐟🪰 HINT: the diversification of CTCF regulation and functions enabled new mechanisms of 3D chromatin folding 🧬 With Liene Astica & @rdacemel.bsky.social Link: www.biorxiv.org/content/10.6... Bluetorial 1/15👇

Many congratulations to Yi Zhu for a fantastic PhD defence — a very well-deserved summa cum laude 🥳 You can read more about Yi's work here: - www.nature.com/articles/s41... - www.biorxiv.org/content/10.6... ...and more to come!

Fantastic opportunity for a PhD with @sproullab.bsky.social exploring DNMT3B functions in development using human stem cell models - excited to be involved! Don’t miss the deadline on 16th November - apply now! 📝

🚨 Looking for a PhD and want to translate mechanistic insights in DNA methylation biology to human development? Great collaboration with @hannahlong.bsky.social and Marcus Wilson. Dissecting DNMT3B functions in human development using human ES cells. 📅 Deadline 16th November 2026

In this episode of the Epigenetics Podcast, we talked with @meleckmas.bsky.social from the Peter McCallum Cancer Center about her work on DPPA2 and DPPA4 as Chromatin Priming Factors. #podcast #epigenetics Listen here: activemotif.com/podcasts-mel...

It was a special privilege to give a Lifetime Achievement Award Lecture at the 6th Danube Conference on Epigenetics in Budapest this week.Thanks to Tamás Arányi and Lóránt Székvölgyi (Epigenetcs Section, Hungarian Biochemical Society) and @ferencmueller.bsky.social for the great introduction.

At least this field of very squishy science is talking about being more rigorous. Notable omission -- if you have a phenotype that looks inherited, sequence the genome for a mediating genetic variant. DNA is a really good way of transmitting information between generations.

Fantastic paper and excellent that the acronym actually has some meaning. I’m sure the community will adopt it without it being awkwardly foisted upon them😉. Congratulations to all the authors!

11 points and 4 pages of comments (!) from a reviewer after the revision. Who does this ? If you want to kill the paper just tell the editor it is not important enough. It would be nicer than forcing us to spend 1 year bogged down in revisions

Did you know that Canada’s maple leaf flag was designed by a Keble alumnus? On 22 October 1964 (62 years ago today) a parliamentary committee considered almost 2,000 suggestions from the Canadian public, and finally voted for George Stanley’s simple and recognisable design 📸: Daniel St Louis

Our work out today in @nature.com! We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects. We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.

Programmable design of functional proteins from natural language www.nature.com/articles/s41... rdcu.be/3N9UHR1SEUSa

Thoroughly enjoying the 6th Danube #epigenetics meeting in Budapest. Lots of great talks so far. Come fine me over coffee if you want to learn about our work on bivalent chromatin our our latest EmbryoRadar preprint www.biorxiv.org/content/10.6..., or to talk about #chronatin more generally!

📢 We are excited to announce our latest work on oocyte meiotic checkpoint signalling @crick.ac.uk Led by George Sioutas, the work allowed us to delineate the early steps of the checkpoint signalling program of pre- and postnatal oocytes 🐭🧬https://www.biorxiv.org/content/10.64898/2026.10.13.758765v2

Saturday was a big day in the Keble calendar! Welcome to our newly matriculated Keblites 🧱

🚨Job Alert Research Technician working with us and the Animal Vibration Lab The successful applicant will work across projects on epigenetics and vibration sensing in various arthropods 🪰🕷️🪲 🧪 Based in the Life and Mind Building @biology.ox.ac.uk my.corehr.com/pls/uoxrecru...

Later today the Dosage Compensation and Evolution of the X Chromosome EMBO Workshop starts at Hokkaido University in Sapporo, Japan. I am looking forward to several days of exciting science and conversations with great colleagues.

i am currently there at the #Purdue marker. If you're in West Lafayette, come see my talk for the Biology dept tomorrow Monday, 11:30!

Are you a postdoc in Cambridge? Consider applying to be a Research Fellow at Clare Hall! @clarehallcambridge.bsky.social www.clarehall.cam.ac.uk/rf/

Check out our new preprint led by @mileshuseyin.bsky.social unexpectedly discovering Polycomb 3D interactions that persist without cPRC1. Also look out for Miles who is on the faculty job market!

Today on the ride 🚴‍♀️ home. Nymphenburg 🏰

Our cover design for Molecular Cell did not get selected this time, but I still wanted to share the artwork celebrating our latest paper identifying an unexpected role for ZC3H18 in cap-dependent first intron splicing article: doi.org/10.1016/j.mo...

Amazing comprehensive Miles, Anders, and team. Such important work for the field!

(1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @andersshansen.bsky.social! We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions: www.biorxiv.org/content/10.6...

Wow, this is amazing, congratulations all!

How can histone acetyl-transferase acetylate a specific histone tail residue ? Using cryo-EM, we captured the MSL complex in a stable post-catalytic state, visualising the acetyl group on H4K16, a central mark for gene regulation authors.elsevier.com/sd/article/S...

Very proud of this study! Two fundamental processes in gene expression turn out less tightly connected than thought. And their relationship may help explain some surprising vulnerabilities of cancer cells. A big thank you to Agata and Deepshika for years of hard work, and kudos to all collaborators!

Go for it! Great lab and mentor!

We are looking for a postdoc. Candidates should have a PhD, at least one first-author paper, hands-on cryo-EM experience, and strong protein biochemistry skills. Please send your CV, research statement, and contact information for three references.

Congratulations Ekin. You have done an absolutely fantastic PhD!

Congratulations Ekin! 🤩

A DTP PhD opportunity in our group: Breaking Code: Deciphering the Biology of the Selfless Virus-like Gene Transfer Agents. Come help us figuring out!!! retweet = nice. Thank you!!! Apply 👉 shorturl.at/1v9ms #PhD #Microsky #phages #GTA #Caulobacter

Dr. Amanda Fisher from the University of Oxford will be presenting groundbreaking research for this year’s P01 Symposium! Save your spot today: nyulangone.zoom.us/webinar/regi... #chromatin2026

1/5 Telomerase has long been linked to chromosome maintenance in eukaryotes. Now, we show that telomerase-like activity is also present in bacteria, shedding new light on its ancient origins. Excited to share that our work on DRT10 is now out in @nature.com! www.nature.com/articles/s41...

How do DNA sequence features tune the timing, level or duration of gene expression? Join us for a 4 year PhD @mrc-lms.bsky.social with @perez-carrasco.bsky.social @jamesware.bsky.social to build models and help us better predict the impact of non-coding sequence variation #devbio #quantitativebio👇

🤓 We have vastly improved our protein domain architecture generator. Check it out here and use it for your next publication: domaindesigner.farnunglab.com

Cycling to work is such a privilege. 😍

Excited to share PostChicago, our lab's new R/Bioconductor package for the analysis of Capture-(Hi)C data downstream of loop calling. We present two of its applications: Meta-profiling of interactions and detection of crosslinking artefacts: www.biorxiv.org/content/10.6...

🚨🧬 We are seeking a PhD student and a postdoc to join our team @mrclmb.ac.uk and investigate co-transcriptional splicing using cryoEM and biochemistry! PhD project: mrclmb.ac.uk/careers-and-... Postdoc call will open soon. Please feel free to get in touch directly. #RNA #cryoEM #PhD #postdoc

How can a #GiantVirus 👾 lurk inside the host genome undetected? We find that epigenetic conflict lies at the centre of the ⚖️ between infection and co-existence with the host. Great collaboration with the Aylward lab out in @biorxivpreprint.bsky.social: www.biorxiv.org/content/10.6...

Today is the official first day of Michaelmas Term. A warm welcome to everyone returning and especially to all joining us for the first time!

Down with condensates !!

Systematic mapping of enhancers, silencers, and topological elements using prime editing deletion screens www.biorxiv.org/content/10.6... Check out our preprint on next-generation tech for mapping distal regulatory effects! We’re excited to help set this up - please get in touch Thread 👇

Excited for this new chapter!

1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity. tinyurl.com/38uf8348

I recently posted the first output of our partnership with Zack Smith's lab, here I post it again this time with the other 2 manuscripts that were generated from this partnership thanks to the fantastic postdoc Yusuke Kijima: www.biorxiv.org/content/10.6...

Postdoc opening @basicsci.fredhutch.org! Great opportunity! Rajan Lab, Fred Hutch: fat-to-brain signals, Atg8 & brain aging. Collaborative fly lab, strong basic-science community, postdocs supported toward independence. From Jan 2027. careers-fhcrc.icims.com/jobs/31508/p...

Fantastic news that Adele Marston will join us in 2027 as Professor of Molecular and Cellular Biochemistry at the University of Oxford. 🎉 🎉 🎉 Read the full story 👇 bit.ly/marston_10_26