Harihar Mohan

Virus-like proteins help our cells respond to environmental stress www.science.org/doi/10.1126/...

Our paper discovering novel roles for the retrovirus-like proteins RTL8 and PEG10 in shaping stress granule biology is now online on Science Advances! #llps #stressgranules www.science.org/doi/full/10....

Earlier this month, I defended my PhD in front of friends and family. As a teenager, I dreamed of this moment and I’m glad it finally came true. Thanks to my mentors, Drs. Paulson and Sharkey and my committee members! I will be starting a postdoctoral position in Dr. Roy Parker’s lab at CU Boulder.

My latest @newscientist.com cartoon

Wow, really stunning pictures!

Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically connecting ‘cell surface RNA biology’ to cancer biology @natbiotech.nature.com www.nature.com/articles/s41...

Mismatch repair inhibitors lift off in Huntington’s www.nature.com/articles/s41...

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

Really cool finding about how VCP protects against bacterial pathogens…

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers https://www.biorxiv.org/content/10.1101/2025.04.07.647611v1

Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41...

Now we’re able to edit proteins directly! Really cool stuff!

A nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA. Enables ‘watching’ of RNP assemblies inside living cells Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com www.nature.com/articles/s41...

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome https://go.nature.com/4iECjJz

Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...

If you have a federal grant, I *highly* recommend going to this Friday's webinar on responding to grant terminations. Lisa Brown, former general counsel at Dept of Ed, will present along with other lawyers. Friday, March 21, 2-3 pm. More info & register here: www.linkedin.com/pulse/regist...

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/

High-quality manuscripts complement scientific value and readability "Views and suggestions for young scientists and early-career researchers on how to prepare a high-quality manuscript." PDF: www.cell.com/action/showP...

This is going to be an important paper for years to come in the HD field! www.nature.com/articles/s41...

I wonder if in the future we could take a CRISPRi pill along with penicillin to get rid of a UTI

Fascinating RNA-mediated changes in memory!

Does anyone have suggestions on detecting viral particle formation in cells fluorescently?

"E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains." -CEO Andrew Payne e11.bio/news/roadmap

Woah, this has so many potential applications! www.nature.com/articles/s41...

"Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations" www.pnas.org/doi/abs/10.1...

This is such a useful tool to study mRNA localization across the whole brain at a single cell resolution. Can’t wait to see studies that use it to map where disease-specific transcripts localize to! www.science.org/doi/10.1126/...

Can we convince all journals to open BlueSky accounts? Once that’s done I’ll officially close my Twitter account! #science

Hi! I’m new here. I’m a 6th year PhD student at Michigan and study endogenous retrovirus-like proteins in stress response, protein quality control and neurodegeneration. Would anyone like to connect? #cellbiology #neurodegeneration #phd