Harrison Specht

Much needed!! Can't wait to try this out.

Update 🙋 V2 Guide to tuning spectral libraries using DIA-NN. --> Geared to proteomics nerds and newbies, alike! dx.doi.org/10.17504/pro...

For those wanting the key insights without the deep methods dive, we published a research briefing in @NatureCVR nature.com/articles/s44... #SpatialProteomics #CardiovascularResearch

A rare, new org. with a vision for public goods and a rapid path to impact! And they use mass spectrometry! #TeamMassSpec take note.

Our machine learning driven quantification algorithm for proteomics now published in Nature Biotechnology. Optimal protein quantification and, for the first time, error estimates for individual quantities. Paper link in comments below.

my views on drug discovery: 1. American/global life sciences academia does a fantastic job of doing basic biological target discovery and disease understanding 2. American/global pharma companies take those discoveries and actually make viable drugs out of them

Pioneer and Altimeter: Fast Analysis of DIA Proteomics Data Optimized for Narrow Isolation Windows www.biorxiv.org/cont... --- #proteomics #prot-preprint

Spatial Proteomics Workshop for Protists (see more in thread below) Registration Early Bird Monday 22nd June 2026. Regular Monday 10th August 2026. There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...

Aside from the whisper network, how are #teammassspec finding out how much certain instrument models are down for (service delays, backordered parts, things breaking all the time, etc)?

Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social ! --> computationalproteomics.khoury.northeastern.edu

#AminoAcidAdvent Day 6: Cysteine (Cys; C) Like Mork & Mindy, these stinky residues love to bond! Jerks like us break these bonds, with chemoproteomics trying to map, probe, and manipulate them. Leftovers stuck to S-S is a fun field but I love them for their antioxidant and metal binding abilities.

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park! “Specialized gas-exchange endothelium of the zebrafish gill” — www.biorxiv.org/content/10.6... Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

The 2026 Chemistry Faculty Jobs List has 330 tenure-track positions and 47 teaching-only positions: docs.google.com/spreadsheets... #facultychemjobs #chemsky #chemchat ⚗️🧪

So which AI peer review tool can tell me authors gave all the Code to make their Figures? 🧪 ✅ Code uses right functions for plot type in Figure? ✅ Is there a 1:1 correspondence between Code and Figures? ❌ Automated reanalysis --> IMO this requires expert knowledge to know the data wasn't hacked

Proteomics + an elegant mechanism! I cannot wait to read in full! #proteomics #TeamMassSpec 🧪

No one is immune to aging but what exactly happens to our immune system as it ages? @thibaultcolombani.bsky.social takes a molecular dive into the immune system and talks about understanding age-induced immune altercations through single-cell proteomics. www.youtube.com/watch?v=WUU1...

Check out our new blog post on barcodes and the future of quickly measuring proteins for biomedical research! 🧪 www.parallelsq.org/blog/barcode...

Exited to share our latest work! Out now in @natcomms.nature.com Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA! www.nature.com/articles/s41...

May Institute on Computation & Statistics for MS and Proteomics is taking great shape. Fantastic new and repeat instructors and lots of new content. We are grateful to our sponsors Fragmatics and Biognosys. Keep an eye on the website computationalproteomics.khoury.northeastern.edu

🧪 Two of my favorite sci-things! Already run q.e.d on my latest bioRxiv submissions :)

🎓 Upcoming Online Course: R/Bioconductor for Mass Spectrometry & Proteomics 📅 November 17–19, 2025 Join Dr Laurent Gatto for a hands-on course on mass spectrometry–based proteomics analysis using R and Bioconductor. 👉 Register & learn more: www.physalia-courses.org/courses-work...

#Proteomics Tutorial drop! Had fun writing this, ping me if interested in other search engines. #TeamMassSpec www.parallelsq.org/blog/fantast...

A bit dense, but the important message is dead simple: We got to cite the E = mc² paper! Kidding :) The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed. Here's how: www.biorxiv.org/content/10.1... #TeamMassSpec #Proteomics 🧪

🧪🔥🔥🔥

AlphaDIA enables DIA transfer learning for feature-free proteomics - @mannlab.bsky.social @jalew188.bsky.social go.nature.com/4qmEQMM

🧪 I tried it and I'm happily surprised! As long as it doesn't boil the oceans, I would run it on all new papers I read for: 🌎 Mapping the interrelatedness of claims -- papers are so complex now! 🔬 Calling out potential gaps -- so that I can know the experiments were properly controlled.

And, we are back with another presentation from this year's Research Fest. PTI's Senior Computational Scientist, Kevin McDonnell, talks about developing joint modeling (aka JMod) of mass spectra for empowering multiplexed DIA proteomics. www.youtube.com/watch?v=plK4...

Well color me curious... and perfect choice of portrait 😂

Increasingly in favour of the Marie Kondo approach to collaborations in science. Does your collaborator spark joy? If not ➡️♻️🗑️ No one's skills or knowledge are so unique or indispensable that they get to make your day miserable with every interaction. 🧪🔭

I'm a huge fan of this proposal! If we can get vendor buy-in to an open, common format, it could bring more computational folks into the field. How can these folks be excited about #proteomics when its hard to even read the already complicated data? pubs.acs.org/doi/10.1021/...

Throwback Thursday continues with a presentation by Maddy Yeh and Mark Adamo from Research Fest: "Tags for improving peptide sequencing and throughput in sensitive proteomics". Watch on YouTube: www.youtube.com/watch?v=jA2I...

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

When that mass spectrometry data gives Patrick vibes ... (so sorry in advance, couldn't resist)

@jasonderks.bsky.social is presenting at iSCMS! Come by this Saturday afternoon around 2pm to hear his talk: "Increasing proteomics throughput by multiplexing in the mass and time domains". singlecellms.org?page_id=442

don't release preprints without a Methods section don't release preprints with a Supplementary Materials section don't release preprints without data don't release preprints without code use preprint servers to share your science, not advertisements

Lazy Sunday (or manic Monday depending on when you look) question to proteomics skywalkers: does/can fragpipe make mzID files for a full PRIDE dataset? Surely, right, but all I see are pep.xml.

Join us for the guest lecture of Prof. Olga Vitek olgavitek.bsky.social, leading computational mass spec expert, for cutting-edge Stats & AI insights on Sep 24, 10am, in person or zoom. Registration: ucdavis.zoom.us/meeting/regi... #Metabolomics #AI #Massspectrometry @mikelangelipid.bsky.social

I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level: Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging elifesciences.org/articles/96892

😎 I love seeing these new, creative approaches to metalloproteomics! A new frontier. 🧪

Really cool talk by @nmriley.bsky.social on glyco mass spec just now at the @cecamevents.bsky.social meeting on glycans in Cagliari. Check out his group’s cool work here: www.riley-research.com/research

There’s a route that our drug molecules can take after dosing that we haven’t been paying enough attention to. Many might not even realize it exists;

New paper in @ScienceMagazine with Schoof & Porse labs: We chart early human hematopoiesis using single-cell proteomics, and amongst others developed a dynamic model linking RNA to protein levels, explaining more proteomic variation. 📄 www.science.org/doi/10.1126/...

Probabilistic scoring of DIA matches without spectral deconvolution? Not only is it possible, we're working on implementing it in Mascot DIA. www.matrixscience.com/blog/probabi... #proteomics #massspec

Our recent ADP-ribosylation study is now online. many #HDL proteins circulate in ribosylated forms, accumulating in plaques. This work opens a new field in dyslipidemia research! #TeamMassSpec @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/...

Do you or your lab use the Skyline software for #MassSpectrometry #proteomics? I'm looking for instructors to help with this year's Skyline Online, a virtual workshop/crash-course for all things Skyline! I'm especially looking for early career researchers for this opportunity. Please DM!

What determines the human gut fungal community? @emilyvansyoc.bsky.social @erdavenport.bsky.social @symbionticism.bsky.social &co present the first #GWAS of human genetic loci that influence the abundance of gut #fungi, linking these to disease risk #mycobiome @plosbiology.org 🧪 plos.io/42bCKou

Celebrating Al Burlingame's 41 years of the @asbmb.bsky.social Molecular and Cellular Proteomics meeting which he started before "proteomics" was a term. Congrats Al!