Lindsay K Pino

Lindsay K Pino

@lindsaykpino.com

#massspectrometry, #proteomics, and #bioinformatics | hiking and coffee | co-founder & CTO @talusbio | opinions my own

1.8K followers1.7K following721 posts

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Lindsay K Pino
@lindsaykpino.com

Hello! 👋 Most of you are friends from Twitter/X already, but for those new connections, a brief intro: I'm a #massspectrometry #proteomic scientist 👩‍🔬, and CTO/co-founder of a #DrugDiscovery company working on targeting transcription factors called Talus Bio. 1/

Lindsay K Pino reposted

Srinivas Ramachandran
@4everbiochemist.bsky.social

Chromatin regulators move nucleosomes in 10 bp steps that preserve rotational setting, using the shallow energy potential that DNA sequence creates. www.cell.com/cell-reports... 🧵

cell.comRotational settings quantize nucleosome movement by chromatin regulatorsChromatin regulators are thought to override intrinsic DNA sequence preferences. La et al. show regulators move nucleosomes in quantized 10 bp steps to take advantage of the shallow energy potential c...
Lindsay K Pino
@lindsaykpino.com

I love these kind of "perspective" talks, what a great start to the day. @jyates.bsky.social

Scripps Research@scripps.edu

Tomorrow, Scripps Research professors John Yates III and Jeffery Kelly, both 2026 Canada Gairdner International Award laureates, take the stage at #GairdnerScienceWeek. The free event, hosted by The Gairdner Foundation, will be livestreamed. Register: https://bit.ly/laureatelectures2026

bit.ly2026 Laureate LecturesThe Laureate Lectures offer a rare opportunity to hear directly from the 2026 Canada Gairdner Award recipients as they share the stories and science behind...

Lindsay K Pino reposted

Scripps Research
@scripps.edu

Tomorrow, Scripps Research professors John Yates III and Jeffery Kelly, both 2026 Canada Gairdner International Award laureates, take the stage at #GairdnerScienceWeek. The free event, hosted by The Gairdner Foundation, will be livestreamed. Register: https://bit.ly/laureatelectures2026

bit.ly2026 Laureate LecturesThe Laureate Lectures offer a rare opportunity to hear directly from the 2026 Canada Gairdner Award recipients as they share the stories and science behind...

Lindsay K Pino reposted

STAT
@statnews.com

"'You Can See Everything' is a hilarious, thrilling, fascinating, beautiful piece of art. What it certainly is not is a documentary, and it’s dangerous to pretend that it is," Theranos whistleblower Tyler Shultz writes. https://bit.ly/4Bk2nDJ

statnews.comI was a Theranos whistleblower. In ‘You Can See Everything,’ Elizabeth Holmes is still lyingA more accurate name would be “You Can See Everything That We Chose To Point The Camera At,”Theranos whistleblower Tyler Shultz writes.

Lindsay K Pino reposted

Olga Vitek
@olgavitek.bsky.social

Replying to @us-hupo.org

Please join us at May Institute online in November vitek-lab.github.io/MIe-2026/ and/or in person in May computationalproteomics.khoury.northeastern.edu for a thorough discussion of these and related statistical issues

vitek-lab.github.ioMay Institute Essentials 2026May Institute Essentials is a condensed, fully virtual version of the May Institute, focused on computation and statistics for mass spectrometry–based proteomics. November 2–6, 2026, online.
Lindsay K Pino
@lindsaykpino.com

Seasonally appropriate "this out to be good" meme gif

US HUPO@us-hupo.org

How do you set cutoffs for differential abundance in proteomics? FDR adjustment helps address multiple testing, yet some studies use nominal p-values + fold-change cutoffs. What role should study goals, statistical power, and validation play? #Proteomics #USHUPO

Lindsay K Pino
@lindsaykpino.com

Congrats to @searleb.bsky.social on getting this out!

Alison Chaves@alisonchaves.bsky.social

I like this one. We need more work in the veterinary field. Our cats are grateful. Leveraging Urinary Proteomics to Advance Pathophysiologic and Biomarker Perspectives of Chronic Kidney Disease in Cats pubs.acs.org/jprobs/artic...

pubs.acs.orgLeveraging Urinary Proteomics to Advance Pathophysiologic and Biomarker Perspectives of Chronic Kidney Disease in CatsAbstract. Chronic kidney disease (CKD) is one of the most prevalent diseases in feline medicine. Mass spectrometry-based urinary proteomics offers powerful

Lindsay K Pino reposted

Chris Ashwood
@cashwood.proteaglyco.com

While conferences are great, I really enjoy convening the Skyline small molecule course because a big group of us (~50) get to dive deep into analysing small molecule data in Skyline. We've been lucky enough to have some great lecturers/instructors this year, covering lipidomics to ion mobility.

Lindsay K Pino reposted

Ben Neely
@benneely.com

I live under a rock, or maybe just don't know anything (call me Jon Snow)... but I just heard about a very deserving pioneer and pillar of our field (and a genuinely good human) getting a fancy award. So BIG congrats, John @jyates.bsky.social! www.gairdner.org/winner/john-...

gairdner.orgJohn R. Yates IIIJohn R. Yates III is the John Lytton Young Professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institut...

Lindsay K Pino reposted

Ben Neely
@benneely.com

So apparently Ben @proteomicsnews.bsky.social went off to London to some International Single Cell Mass Spec (iSCMS) conference and did a special LIVE! episode of #THEProteomicsShow, with co-host Melanie Bailey. They talked to Ed Emmott @edemmott.bsky.social about single cells I assume (and more!).

creators.spotify.comEp 113 - LIVE! from iSCMS 2026 - Dr. Edward Emmott by The Proteomics ShowA special live show from the 2026 International Single Cell Mass Spectrometry Conference (iSCMS) in London. Ben Orsburn was joined by special co-host Prof. Melanie Bailey from King’s College London, a...

Lindsay K Pino reposted

Will Fondrie
@handle.invalid

#OSS maintainers, how do you deal with inbound PRs on packages you maintain these days? In the past, I'd review them and then folks would make requested changes. However, these days its often easier and faster just to have an agent make the fixes and update the PR. Thoughts?

Lindsay K Pino reposted

US HUPO
@us-hupo.org

📣 One week until AI-Ready Presented by the US HUPO Early Career Research Group, this Oct. 14 webinar features Brian Searle & Patricia Opitz discussing AI applications in proteomics. 🕐 7 AM PDT | 10 AM EDT 🔗 https://us02web.zoom.us/webinar/register/WN_gkr3AFjhQ1m7QY6teUXk2Q #Proteomics #AI #USHUPO

us02web.zoom.usWelcome! You are invited to join a webinar: US HUPO ECR - AI-Ready: Artificial Intelligence in Proteomics Research and Practice. After registering, you will receive a confirmation email about joining the webinar.This webinar aims to equip early-career researchers to become AI-ready by providing practical solutions for incorporating artificial intelligence into the proteomics workflow.

Lindsay K Pino reposted

Michael Lazear
@michaellazear.bsky.social

As part of my overhaul of Sage's automated testing infrastructure I put together a dashboard that aggregates the anonymized telemetry reports Sage collections - great timing, because Sage just hit 1,000,000 logged searches globally. sage.lazear.org/usage

Michael Lazear@michaellazear.bsky.social

Have you ever wanted to run a proteomics search engine directly in your browser? No, I haven't either... But now you can! All of your data stays on your local computer, and you can run Sage (with some experimental features 😀) through a nice UI without installing anything. sage.lazear.org/search/

Lindsay K Pino reposted

Will Fondrie
@handle.invalid

Replying to @handle.invalid

(8/8) Ptarmigan-1 is open for access through our web portal, and I can't wait to see what it does for you. 👇 🐦 Try Ptarmigan-1: ptarmigan.app 📰 Press release: www.businesswire.com/news/home/20... ✏️ Blog: blog.talus.bio/p/c0a4b0c3-c...

ptarmigan.appPtarmigan-1 — Protein–compound predictions by Talus BioPrioritize compounds for experimental testing with Ptarmigan-1. Screen protein targets against compound libraries without requiring a protein structure.

Lindsay K Pino reposted

Will Fondrie
@handle.invalid

Replying to @handle.invalid

(7/8) I asked Alex, our CEO, for his favorite new molecules and their targets, and each one I tried worked, whether the model had seen the target before or not, including disordered targets like transcription factors that have never been reachable this way.

Lindsay K Pino reposted

Will Fondrie
@handle.invalid

Replying to @handle.invalid

(6/8) One of my favorite feelings in science is when an experiment works and you realize you are the first person in the world to have seen it. An early Ptarmigan model gave me exactly that.

Lindsay K Pino reposted

Will Fondrie
@handle.invalid

Replying to @handle.invalid

(5/8) Everything works on well-behaved, structured targets with clear pockets, and everything beyond that is the frontier. I remember thinking that we can measure these targets, so surely there must be a better way to model them. Ptarmigan was born on the plane ride home.

Lindsay K Pino
@lindsaykpino.com

It's Ptarmigan Ptime!! Structure-agnostic small molecule screening. Try your floppiest, most disordered proteins!! 🍝 🧬 💻

Will Fondrie@handle.invalid

We released Ptarmigan-1 last week, our structure-free AI model for proteome-wide drug discovery. The model reaches all proteins, including the 40% that have no fixed structure, and can run 3.4 billion compounds against every human protein in a day. 🐦 Try Ptarmigan-1 for free: ptarmigan.app 🧵 (1/8)

ptarmigan.appPtarmigan-1 — Protein–compound predictions by Talus BioPrioritize compounds for experimental testing with Ptarmigan-1. Screen protein targets against compound libraries without requiring a protein structure.

Lindsay K Pino reposted

Will Fondrie
@handle.invalid

We released Ptarmigan-1 last week, our structure-free AI model for proteome-wide drug discovery. The model reaches all proteins, including the 40% that have no fixed structure, and can run 3.4 billion compounds against every human protein in a day. 🐦 Try Ptarmigan-1 for free: ptarmigan.app 🧵 (1/8)

ptarmigan.appPtarmigan-1 — Protein–compound predictions by Talus BioPrioritize compounds for experimental testing with Ptarmigan-1. Screen protein targets against compound libraries without requiring a protein structure.
Lindsay K Pino
@lindsaykpino.com

Planning out a new mass spec room. On a scale of "not at all" to "rip them out", how concerned should I be able ceiling tiles? Like for a drop ceiling.

Lindsay K Pino reposted

Richard Sever
@richardsever.bsky.social

As AI increases both productivity & ease of creating slop, there's a big challenge for those of us disseminating science. This from @pracheeac.bsky.social is an essential read. [disclaimer: she & I've spent 10+ years a̶r̶g̶u̶i̶n̶g̶ ̶a̶b̶o̶u̶t̶ discussing this stuff] 1/n pracheeac.substack.com/p/arxiv-is-k...

pracheeac.substack.comarXiv Is Killing Itself So AI Doesn't Have ToDisclosure: I ranted to Claude with a bunch of my grievances and ideas, and had it organize them into this blog post.

Lindsay K Pino reposted

Brett Phinney
@ucdproteomics.bsky.social

I asked Claude to make podcast where a statistician and biologist discuss the proteomics results run through my claude proteomics skill and while it's not as good as @benneely.com podcast, but it's not bad either :) it's in the newest version of the skill github.com/bsphinney/DE...

github.comGitHub - bsphinney/DE-LIMP: LIMPA DAVIS Proteomics PipelineLIMPA DAVIS Proteomics Pipeline. Contribute to bsphinney/DE-LIMP development by creating an account on GitHub.
Lindsay K Pino
@lindsaykpino.com

"On-the-job training is the third most common source of proteomics expertise today with 13.1% of responses." Wow that's much lower than I expected. (The other two options were "learn in grad school" and "learn in postdoc")

Kermit Murray@kkmurray.bsky.social

(JASMS) Where Do Proteomics People Come from?: AbstractThe field of proteomics is one of the fastest-growing scientific disciplines in the world today. Beginning in 2020, ambitious market predictions anticipated proteomics to more than double in market size in 4–6 years and to… (RSS) #MassSpecRSS

dlvr.itWhere Do Proteomics People Come from?AbstractThe field of proteomics is one of the fastest-growing scientific disciplines in the world today. Beginning in 2020, ambitious market predictions anticipated proteomics to more than double in market size in 4–6 years and to even surpass the well-established genomic sciences industry in 8–12 years. While the market is still growing, it has not come close to matching the initial projections. To better understand the root cause of this, the author has collected field surveys and direct interviews of over 200 scientists actively involved in proteomics research today. While ultimately incomplete, it is worth noting that over 68% of respondents received their technical training in proteomics during either their doctoral or postdoctoral training. In stark contrast, only 4.3% of students obtained training during their undergraduate education. Given the 5.7-to-9.4-year average cycle for traditional doctoral and postdoctoral training in the life sciences, it appears the limiting factor in growing the proteomics field may be linked directly to current practices in training a qualified workforce.

Lindsay K Pino reposted

Kermit Murray
@kkmurray.bsky.social

(JASMS) Where Do Proteomics People Come from?: AbstractThe field of proteomics is one of the fastest-growing scientific disciplines in the world today. Beginning in 2020, ambitious market predictions anticipated proteomics to more than double in market size in 4–6 years and to… (RSS) #MassSpecRSS

dlvr.itWhere Do Proteomics People Come from?AbstractThe field of proteomics is one of the fastest-growing scientific disciplines in the world today. Beginning in 2020, ambitious market predictions anticipated proteomics to more than double in market size in 4–6 years and to even surpass the well-established genomic sciences industry in 8–12 years. While the market is still growing, it has not come close to matching the initial projections. To better understand the root cause of this, the author has collected field surveys and direct interviews of over 200 scientists actively involved in proteomics research today. While ultimately incomplete, it is worth noting that over 68% of respondents received their technical training in proteomics during either their doctoral or postdoctoral training. In stark contrast, only 4.3% of students obtained training during their undergraduate education. Given the 5.7-to-9.4-year average cycle for traditional doctoral and postdoctoral training in the life sciences, it appears the limiting factor in growing the proteomics field may be linked directly to current practices in training a qualified workforce.

Lindsay K Pino reposted

Vaughn Cooper
@vscooper.micropopbio.org

FYI to everyone submitting this October NIH cycle You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted. Great timing!